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Excitotoxic mechanisms in the pathogenesis of dementia
Neurochemistry International, 1994Alzheimer disease and related dementias, in common with most major neurological diseases, are characterized by localized brain damage. An abundance of senile plaques and neurofibrillary tangles in certain brain areas is pathognomic of the disease: of the two, the density of tangles may correlate more closely with disease severity ante mortem.
Dodd, PR, Scott, HL, Westphalen, RI
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Excitotoxicity in Aging and Dementia
1983The extracellular concentration of glutamate in the neocortex of human brain may-increase progressively with ageing. Glutamergic nerve terminals seem to be a major source of the amino acid. There is no evidence that the concentration of extracellular glutamate is increased in the neocortex in Alzheimer’s disease.
D. M. Bowen +2 more
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Excitotoxicity in neonatal hypoxia
Mental Retardation and Developmental Disabilities Research Reviews, 2001AbstractHypoxic‐ischemic encephalopathy (HIE) in neonates is a disorder of excessive neuronal excitation that includes seizures, abnormal EEG activity, and delayed failure of oxidative metabolism with elevated levels of lactic acid in the brain. Evidence from experimental models and clinical investigation indicates that HIE is triggered by a profound ...
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EXCITOTOXICITY AS A STOCHASTIC PROCESS
Clinical and Experimental Pharmacology and Physiology, 1995SUMMARY1. Neuronal death following excitotoxic insult appears to be a stochastic process involving transition through an intermediate biochemical state.2. Hydrogen ion accumulation in the hours after toxic glutamate exposure may indicate that this transition has occurred.
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Journal of Neurobiology, 1992
AbstractExcitotoxicity refers to the ability of glutamate or related excitatory amino acids to mediate the death of central neurons under certain conditions, for example, after intense exposure. Such excitotoxic neuronal death may contribute to the pathogenesis of brain or spinal cord injury associated with several human disease states.
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AbstractExcitotoxicity refers to the ability of glutamate or related excitatory amino acids to mediate the death of central neurons under certain conditions, for example, after intense exposure. Such excitotoxic neuronal death may contribute to the pathogenesis of brain or spinal cord injury associated with several human disease states.
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2008
Autism spectrum disorders are neurodevelopmental disorders characterized by deficits in social skills, communication, and motor function, as well as compulsive and repetitive behaviors and interests. Although these disorders are thought to be of multifactorial origin, with a wide range of genetic and environmental factors implicated, we propose that ...
Martin Evers, Eric Hollander
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Autism spectrum disorders are neurodevelopmental disorders characterized by deficits in social skills, communication, and motor function, as well as compulsive and repetitive behaviors and interests. Although these disorders are thought to be of multifactorial origin, with a wide range of genetic and environmental factors implicated, we propose that ...
Martin Evers, Eric Hollander
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Wernicke’s encephalopathy: an excitotoxicity hypothesis
Metabolic Brain Disease, 1997Thiamine deficiency is a recognized cause of Wernicke's encephalopathy (WE), a condition in which small necrotic lesions are found in close proximity to the third and fourth ventricles and the Sylvian aqueduct. Although the neuropathology of WE is well-established, the pathogenic mechanisms that determine the formation and distribution of brain lesions
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1997
This chapter presents an overview of the excitotoxic concept and its putative involvement in hypoxic–ischemic brain damage. Excitotoxicity refers to the central neuronal injury or death induced by glutamate or related excitatory amino acids. Most excitotoxicity is mediated by glutamate receptors, although prolonged exposure to very high concentrations ...
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This chapter presents an overview of the excitotoxic concept and its putative involvement in hypoxic–ischemic brain damage. Excitotoxicity refers to the central neuronal injury or death induced by glutamate or related excitatory amino acids. Most excitotoxicity is mediated by glutamate receptors, although prolonged exposure to very high concentrations ...
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