Results 311 to 320 of about 95,867 (358)

Role of nitric oxide in cerebral ischemia/reperfusion injury: A biomolecular overview.

open access: yesWorld J Clin Cases
Anaya-Prado R   +16 more
europepmc   +1 more source
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The overlooked aspect of excitotoxicity: Glutamate‐independent excitotoxicity in traumatic brain injuries

European Journal of Neuroscience, 2018
Traumatic brain injury (TBI) is a leading major cause of morbidity and mortality in youth and individuals under 45 year age. A wide variety of cellular and molecular mechanisms have been identified contributing to the pathogenesis of TBI.
Joel Tehse, C. Taghibiglou
semanticscholar   +4 more sources

Alternative excitotoxic hypotheses [PDF]

open access: possibleNeurology, 1992
The concept of excitotoxicity, neuronal death produced by overstimulation of excitatory amino acid receptors, has become a popular way of explaining the pathogenesis of neuronal death in a variety of acute and chronic neurologic diseases. While there is strong evidence supporting the role of excitotoxicity in acute processes such as hypoxia/ischemia ...
J. T. Greenamyre, Roger L. Albin
openaire   +2 more sources

Excitotoxicity as a Target against Neurodegenerative Processes.

Current pharmaceutical design, 2020
The global burden of neurodegenerative diseases is alarmingly increasing in parallel to the aging of population. Although the molecular mechanisms leading to neurodegeneration are not completely understood, excitotoxicity, defined as to the injury and ...
Octavio Binvignat, J. Olloquequi
semanticscholar   +1 more source

Excitotoxicity and mitochondria

Biochemical Society Symposia, 1999
Excitotoxicity is the process whereby a massive glutamate release in the central nervous system in response to ischaemia or related trauma leads to the delayed, predominantly necrotic death of neurons. Excitotoxicity is also implicated in a variety of slow neurodegenerative disorders.
Samantha L. Budd   +3 more
openaire   +3 more sources

Excitotoxicity in ALS

Neurology, 1996
This review will summarize current understanding of the molecular and cellular mechanisms of excitotoxicity, the organization of glutamate systems in relation to ALS and evidence that excitotoxicity is relevant to the pathogenesis of ALS.
B. S. Meldrum, P. N. Leigh
openaire   +3 more sources

Excitotoxicity in the Pathogenesis of Autism

Neurotoxicity Research, 2012
Autism is a debilitating neurodevelopment disorder characterised by stereotyped interests and behaviours, and abnormalities in verbal and non-verbal communication. It is a multifactorial disorder resulting from interactions between genetic, environmental and immunological factors.
Selvaraju Subash   +5 more
openaire   +3 more sources

Excitotoxicity in glial cells [PDF]

open access: possibleEuropean Journal of Pharmacology, 2002
Excitotoxicity results from prolonged activation of glutamate receptors expressed by cells in the central nervous system (CNS). This cell death mechanism was first discovered in retinal ganglion cells and subsequently in brain neurons. In addition, it has been recently observed that CNS glial cells can also undergo excitotoxicity.
Gaskon Ibarretxe   +3 more
openaire   +2 more sources

Pathophysiology of oligodendroglial excitotoxicity

Journal of Neuroscience Research, 1996
Oligodendrocyte-like cells (OLD) derived from the rat oligodendroglial precursor line, CG-4, express Ca(2+)-permeable non-methyl-D-aspartate glutamate receptor channels (GluR). Exposure to kainate, an L-glutamate analogue, markedly elevates OLC Ca2+ influx and cytosolic [Ca2+], and results in damage to both OLC plasma membrane and OLC nuclear DNA.
Akira Yoshioka   +2 more
openaire   +3 more sources

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