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Role of nitric oxide in cerebral ischemia/reperfusion injury: A biomolecular overview.
World J Clin CasesAnaya-Prado R +16 more
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European Journal of Neuroscience, 2018
Traumatic brain injury (TBI) is a leading major cause of morbidity and mortality in youth and individuals under 45 year age. A wide variety of cellular and molecular mechanisms have been identified contributing to the pathogenesis of TBI.
Joel Tehse, C. Taghibiglou
semanticscholar +4 more sources
Traumatic brain injury (TBI) is a leading major cause of morbidity and mortality in youth and individuals under 45 year age. A wide variety of cellular and molecular mechanisms have been identified contributing to the pathogenesis of TBI.
Joel Tehse, C. Taghibiglou
semanticscholar +4 more sources
Alternative excitotoxic hypotheses [PDF]
Neurology, 1992 The concept of excitotoxicity, neuronal death produced by overstimulation of excitatory amino acid receptors, has become a popular way of explaining the pathogenesis of neuronal death in a variety of acute and chronic neurologic diseases. While there is strong evidence supporting the role of excitotoxicity in acute processes such as hypoxia/ischemia ...
J. T. Greenamyre, Roger L. Albin
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Excitotoxicity as a Target against Neurodegenerative Processes.
Current pharmaceutical design, 2020The global burden of neurodegenerative diseases is alarmingly increasing in parallel to the aging of population. Although the molecular mechanisms leading to neurodegeneration are not completely understood, excitotoxicity, defined as to the injury and ...
Octavio Binvignat, J. Olloquequi
semanticscholar +1 more source
Excitotoxicity and mitochondria
Biochemical Society Symposia, 1999Excitotoxicity is the process whereby a massive glutamate release in the central nervous system in response to ischaemia or related trauma leads to the delayed, predominantly necrotic death of neurons. Excitotoxicity is also implicated in a variety of slow neurodegenerative disorders.
Samantha L. Budd +3 more
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Neurology, 1996
This review will summarize current understanding of the molecular and cellular mechanisms of excitotoxicity, the organization of glutamate systems in relation to ALS and evidence that excitotoxicity is relevant to the pathogenesis of ALS.
B. S. Meldrum, P. N. Leigh
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This review will summarize current understanding of the molecular and cellular mechanisms of excitotoxicity, the organization of glutamate systems in relation to ALS and evidence that excitotoxicity is relevant to the pathogenesis of ALS.
B. S. Meldrum, P. N. Leigh
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Excitotoxicity in the Pathogenesis of Autism
Neurotoxicity Research, 2012Autism is a debilitating neurodevelopment disorder characterised by stereotyped interests and behaviours, and abnormalities in verbal and non-verbal communication. It is a multifactorial disorder resulting from interactions between genetic, environmental and immunological factors.
Selvaraju Subash +5 more
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Excitotoxicity in glial cells [PDF]
European Journal of Pharmacology, 2002 Excitotoxicity results from prolonged activation of glutamate receptors expressed by cells in the central nervous system (CNS). This cell death mechanism was first discovered in retinal ganglion cells and subsequently in brain neurons. In addition, it has been recently observed that CNS glial cells can also undergo excitotoxicity.
Gaskon Ibarretxe +3 more
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Pathophysiology of oligodendroglial excitotoxicity
Journal of Neuroscience Research, 1996Oligodendrocyte-like cells (OLD) derived from the rat oligodendroglial precursor line, CG-4, express Ca(2+)-permeable non-methyl-D-aspartate glutamate receptor channels (GluR). Exposure to kainate, an L-glutamate analogue, markedly elevates OLC Ca2+ influx and cytosolic [Ca2+], and results in damage to both OLC plasma membrane and OLC nuclear DNA.
Akira Yoshioka +2 more
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