Results 71 to 80 of about 937,952 (246)

Asthma: From Phenotypes to Endotypes—Beyond Type 2 Inflammation

Respirology, EarlyView.
ABSTRACT Asthma is a heterogeneous syndrome featuring variable pathophysiology, clinical presentation and treatment response. This review examines a comprehensive endotype‐phenotype framework for asthma assessment with an emphasis on characteristics beyond T2 inflammatory status alone.
Mario Fernando, Gregory G. King
wiley   +1 more source

Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis [PDF]

, 2009
Insulin stimulates endothelial NO (nitric oxide) synthesis via PKB (protein kinase B)/Akt-mediated phosphorylation and activation of eNOS (endothelial NO synthase) at Ser-1177.
Boyd, Alasdair R., Stuart A. Ritchie, Ian P. Salt, Salt, Ian P., Kohlhaas, Christine F, Yalla, Krishna C, Kohlhaas, Christine F., Boyd, Alasdair R, Krishna C. Yalla, Walsh, Kenneth, Ritchie, Stuart A, John M. C. Connell, Christine F. Kohlhaas, Kenneth Walsh, Ritchie, Stuart A., Connell, John M.C., Connell, John Mc, Salt, Ian P, Alasdair R. Boyd, Yalla, Krishna C.   +19 more
core   +1 more source

Prenatal vitamin d supplementation and child respiratory health: a randomised controlled trial.

PLoS ONE, 2013
BackgroundObservational studies suggest high prenatal vitamin D intake may be associated with reduced childhood wheezing. We examined the effect of prenatal vitamin D on childhood wheezing in an interventional study.MethodsWe randomised 180 pregnant ...
Stephen T Goldring, Chris J Griffiths, Adrian R Martineau, Stephen Robinson, Christina Yu, Sheree Poulton, Jane C Kirkby, Janet Stocks, Richard Hooper, Seif O Shaheen, John O Warner, Robert J Boyle   +11 more
doaj   +1 more source

Sargassum Lung Syndrome: Air Flow Obstruction and Bronchial Inflammation Are Observed After Prolonged Exposure to Sargassum Gas Emissions in the Eastern Caribbean

Environmental Toxicology, EarlyView.
ABSTRACT Sargassum inundation of Caribbean and American shorelines is a growing environmental hazard. Hydrogen sulfide (H2S) and ammonia (NH3) produced by decomposing Sargassum could be involved in airway obstruction and bronchial inflammation. The study was undertaken to evaluate the effects of exposure to H2S and NH3 gases emitted during Sargassum ...
Rishika Banydeen, Jonathan Florentin, Maxime Boutourlinsky, Remi Nguyen, Fatima Radouani, Moustapha Agossou, Gary Lutin, Thierry Lebrun, Remi Neviere, Dabor Resiere   +9 more
wiley   +1 more source

Clinical Utility of Exhaled Nitric Oxide [PDF]

, 2013
Lower airway inflammation is generally classified as eosinophilic or neutrophilic. In conditions where eosinophilic inflammation predominates such as asthma in children, corticosteroids are usually beneficial.
Petsky, Helen, Petsky, Helen L.
core  

MEASUREMENT OF NITRIC OXIDE IN EXHALED AIR AS AN INSTRUMENT OF MONITORING BASIC THERAPY EFFICACY IN CHILDREN WITH BRONCHIAL ASTHMA

Педиатрическая фармакология, 2006
An individual approach to prescribing the most effective therapy for bronchial asthma is one of the actual problems of pediatric. It necessitates the development of new diagnostic markers of disease activity.
S.E. Tsyplenkova
doaj   +2 more sources

L-Arginine Supplementation and Metabolism in Asthma

Pharmaceuticals, 2011
L-Arginine, the amino acid substrate for nitric oxide synthase, has been tested as a therapeutic intervention in a variety of chronic diseases and is commonly used as a nutritional supplement.
Angela Linderholm, Nicholas J. Kenyon, Erin O’Roark, Vivian W. Kwan, Jennifer M. Bratt, Michael Last   +5 more
doaj   +1 more source

Safety, Efficacy, and Mechanism of Action of Budesonide in Rhinitis and Rhinosinusitis: A Systematic Review

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective Budesonide is a corticosteroid with unique pharmacokinetic and pharmacodynamic properties that has been a frontline treatment for patients with allergic rhinitis (AR) and chronic rhinosinusitis (CRS) since the 1990s. As research on budesonide continues to produce new insights, our aim was to synthesize recent investigations and ...
David W. Kennedy, Lei Cheng, De‐Yun Wang   +2 more
wiley   +1 more source

Nitric oxide synthase and the contribution of nitric oxide to vertebrate motor control [PDF]

, 2008
I have explored the role of nitric oxide (NO) and the distribution of its synthetic enzyme in neurons, nNOS, in vertebrate motor control. The CNS of Xenopus laevis tadpoles was used primarily in this investigation as a developmental model of neural ...
Molinari, Micol Ariella
core   +2 more sources

The Role of Exhaled Breath Analyses in Interstitial Lung Disease

Diagnostics
Interstitial lung diseases (ILDs) represent a group of lung disorders that primarily affect the lung parenchyma. These disorders are usually progressive, may be debilitating and life threatening, and often pose diagnostic and therapeutic challenges ...
Panaiotis Finamore, Alessio Marinelli, Simone Scarlata, Silvano Dragonieri, Andras Bikov   +4 more
doaj   +1 more source