Results 121 to 130 of about 2,695,064 (284)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Existence and uniqueness of solution for a singular elliptic differential equation

Advances in Nonlinear Analysis
In this article, we are concerned about the existence, uniqueness, and nonexistence of the positive solution for: −Δu−12(x⋅∇u)=μh(x)uq−1+λu−up,x∈RN,u(x)→0,as∣x∣→+∞,\left\{\begin{array}{l}-\Delta u-\frac{1}{2}\left(x\cdot \nabla u)=\mu h\left(x){u}^{q-1}+\
Gu Shanshan, Yang Bianxia, Shao Wenrui
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A priori estimate and existence of solutions with symmetric derivatives for a third-order two-point boundary value problem

Mathematical Modelling and Analysis
We study a priori estimate, existence, and uniqueness of solutions with symmetric derivatives for a third-order boundary value problem. The main tool in the proof of our existence result is Leray-Schauder continuation principle.
Sergey Smirnov
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Existence and uniqueness of the solution to a 3D thermoviscoelastic system

Electronic Journal of Differential Equations, 2003
This paper presents results on existence and uniqueness of solutions to a three-dimensional thermoviscoelastic system. The constitutive relations of the model are recovered by a free energy functional and a pseudo-potential of dissipation.
Elena Bonetti, Giovanna Bonfanti
doaj  

Existence and uniqueness of solution for a fractional hepatitis B model

Computational and Mathematical Biophysics
Understanding the dynamics of infectious diseases using mathematical modeling is essential for developing prevention and control measures. Hepatitis B is still a major public health issue in many places, including Kenya, where the high incidence of ...
Aguegboh Nnaemeka Stanley, Oranugo Dominic Obinna, Kiogora Phineas Roy, Felix Mutua, Netochukwu Onyiaji, Egwu Andrew Onyeka   +5 more
doaj   +1 more source

The Existence of a Solution to a Class of Fractional Double Phase Problems

Fractal and Fractional
This paper focuses on the study of a class of fractional p&q-Laplacian problems with unbalanced growth, which includes vanishing potential and a supercritical growth exponent.
Maoji Ri, Yongkun Li
doaj   +1 more source