Results 121 to 130 of about 252,625 (305)

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

The Protective Role of Curiosity Behaviors in Coping with Existential Vacuum

Behavioral Sciences
An existential vacuum is experienced as a kind of crisis that one can cope with using his/her strengths. The related literature suggests that the important determinants of coping with existential emptiness include positive emotional and personality ...
Barbara Gawda, Adrian Korniluk
doaj   +1 more source

Existential Antropology as the Antropology of Education

Дискурс Пи, 2018
The article reveals author's version of the concept of existential anthropology education, where axiological component is strengthened as the basis for education of human being.
N.N. Niyazbaeva
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Inductive Logic [PDF]

, 2018
Inductive Logic is a ‘thematic compilation’ by Avi Sion. It collects in one volume many (though not all) of the essays, that he has written on this subject over a period of some 23 years, which all demonstrate the possibility and conditions of validity ...
Sion, Avi
core  

Bounded Quantifier Instantiation for Checking Inductive Invariants

, 2019
We consider the problem of checking whether a proposed invariant $\varphi$ expressed in first-order logic with quantifier alternation is inductive, i.e. preserved by a piece of code.
Feldman, Yotam M. Y., Immerman, Neil, Padon, Oded, Sagiv, Mooly, Shoham, Sharon   +4 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

“Sometimes I feel like I’m not supposed to think about death, but I do anyway” - exploring the topic of death with children in schools to help them find meaning and foster their wellbeing

Humanities & Social Sciences Communications
The quest to give a meaning to life has spanned centuries, from Plato to the existentialist philosophers and psychologists in the 20th century. Among existential questions that are quasi-universal, those around death occupy a large place.
Catherine Malboeuf-Hurtubise, David Lefrançois, Marc-André Éthier, Jonathan Smith, Kevin Péloquin, Zach Dylan Fry   +5 more
doaj   +1 more source