Results 101 to 110 of about 252,625 (305)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Existential boredom as a phenomenon of human social existence

Sovremennye Issledovaniâ Socialʹnyh Problem
Background. Until now, science lacks a holistic philosophical understanding of the phenomenon of existential boredom and has not developed an attitude towards it, although it is recognized in the scientific community.
Svetlana M. Maltseva, Polina O. Ivanova, Olga P. Kashina   +2 more
doaj   +1 more source

The practice of dealing with existential questions in long-term elderly care

International Journal of Qualitative Studies on Health & Well-Being, 2018
Purpose: Existential questions concerning life and death or meaning in life are very salient for many older people receiving long-term care. However, little is known about how long-term care organizations deal with existential issues.
Wander van der Vaart, Rosanna van Oudenaarden   +1 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The Existential Vacuum and Its Relationship to Pessimism and Optimism among Undergraduate Students

Islamic Guidance and Counseling Journal
University students may confront an existential vacuum, characterized by a loss of life's meaning resulting from personal crises, socio-political shifts, and health transformations. These challenges, which some young individuals may struggle to adapt to,
Mohammed H. Abood, Thaer A. Ghbari
doaj   +1 more source

Lost in an unknown terrain: a phenomenological contribution to the understanding of existential concerns as experienced by young women in Sweden

International Journal of Qualitative Studies on Health & Well-Being, 2019
Purpose: The aim of this study is to describe young women’s (16–25 years old) experiences of living with existential concerns for which they have sought support from healthcare professionals, teachers, family, or friends, among others.
Maria Lundvall, Elisabeth Lindberg, Ulrica Hörberg, Gunilla Carlsson, Lina Palmér   +4 more
doaj   +1 more source

Spiritual and existential meanings of death and dying : a palliative nursing care perspective. [PDF]

, 2011
This study aimed to explore the ways palliative care nurses conceptualised the death and dying experiences of their patients. Spiritual and existential meaning-making was a particular focus, as well as the ways in which these intersected with Elisabeth ...
Gordon, Kerry Joan
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Why We Should Create Artificial Offspring: Meaning and the Collective Afterlife [PDF]

, 2018
This article argues that the creation of artificial offspring could make our lives more meaningful. By ‘artificial offspring’ I mean beings that we construct, with a mix of human and non-human-like qualities.
Danaher, John
core