Results 91 to 100 of about 1,366,829 (246)
Existential Boredom Re-examined
, 2019 This paper takes issue with interpretations of boredom as an existential mood that must be avoided. Through addressing some of the inconsistencies in Heidegger’s account of boredom, and relatedly exploring its intricate relationship with nothingness ...
Gilliam, Christian
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Existential Parallelism: Identity, Meaning, and Behavioral Drift in Contemporary Society
Existential Parallelism: Identity, Meaning, and Behavioral Drift in Contemporary Society This project develops the theoretical and methodological framework of Existential Parallelism, an approach designed to understand how individuals navigate identity ...
Élison Silva Santos
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Hopelessness, Presence of Meaning in Life, and Existential Concern: A Latent Profile Analysis
Psikiyatride Güncel YaklaşımlarObjective: The present study uses the variables of hopelessness, the presence of meaning in life, and existential concern to obtain a broad conceptualization of suicide risk and aims to uncover distinct latent subgroups formed by these variables. It also
Mehmet Sarıçalı, Ersoy Çarkıt
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Anxiety’s ambiguity: an investigation into the meaning of anxiety in existentialist philosophy and literature [PDF]
, 1997 The dissertation has two primary aims: 1) To investigate the significance and role of anxiety in the work of existentialist writers; 2) To synthesize a unified account of its meaning within this tradition.
Hanscomb, S.R., Hanscomb, Stuart Roy
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Existential boredom as a phenomenon of human social existence
Sovremennye Issledovaniâ Socialʹnyh ProblemBackground. Until now, science lacks a holistic philosophical understanding of the phenomenon of existential boredom and has not developed an attitude towards it, although it is recognized in the scientific community.
Svetlana M. Maltseva +2 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Frontiers in PsychologyObjectiveGrounded in Second Wave Positive Psychology (PP2.0), this study conceptualizes resilient mindset as a positive cognitive schema associated with the internalization of external relational and existential resources, rather than merely a static ...
Kuan-Ling Lin, Ying Chen, Ying Chen
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
, 2017 Aims: Present results from focus interviews concerning existential aspects related to the adaptation of the WHOQOL-SRPB(BREF) for Swedish adolescents.Background: Exploring existential aspects of HRQL are important when mental ill-health is increasing ...
Söderqvist, Fredrik, +1 more
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