Results 91 to 100 of about 25,750 (260)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

'You only have one chance to get it right': A qualitative study of relatives' experiences of caring at home for a family member with terminal cancer.

, 2015
BACKGROUND: Relatives looking after a terminally ill family member at home face numerous challenges. Studies into relatives’ experiences of home caregiving have been criticised for their descriptive nature and lack of theoretical underpinnings.
Jonathan Martin (433491), Martin, J, Smith, S, Jonathan Totman (16670103), Susan Smith (377252), Totman, J, Susan Hennessey (16670106), Hennessey, S, Pistrang, N, Nancy Pistrang (42843)   +9 more
core  

Finding meaning through emotional understanding: emotional clarity predicts meaning in life and adjustment to existential threat

If emotions provide information relevant to personal meaning, then people with a greater sense of clarity about their emotions may possess some advantages in finding meaning in their lives.
Robinson, Michael, Abeyta, Andrew, Routledge, Clay, Juhl, Jacob   +3 more
core   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Older people with incurable cancer : Existential meaning-making from a life-span perspective

, 2016
Objective: An increasing number of older people in Western countries are living with incurable cancer, receiving palliative care from specialized healthcare contexts.
Danbolt, Lars J., Haug, Sigrid Helene Kjørven, Kvinge, Kari, DeMarinis, Valerie,   +3 more
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

An empirical investigation of the relationship between existential meaning-in-life and racial prejudice [PDF]

, 2006
Thesis (MA (Psychology))--University of Stellenbosch, 2006.This study had two main objectives: Firstly, to investigate the relationship between existential meaning-in-life and racial prejudice amongst students at Stellenbosch University; secondly to ...
Niemand, Johannes Rust
core  

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

The Ethical and Existential Meaning of Beauty

Journal of Design, Planning and Aesthetics Research, 2022
openaire   +5 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source