Results 71 to 80 of about 1,366,829 (246)

Spanish Validation of the Multidimensional Existential Meaning Scale: Which Dimension of Meaning in Life Is More Associated With Psychopathology in People With Mental Disorders? [PDF]

Front Psychiatry, 2022
Marco JH, García-Alandete J, Pérez Rodríguez S, Guillén V, Baños RM, Tormo-Irun MP.   +5 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The Hermeneutics of Values in the Novel A Portion of Chicken Noodles Before Dying as a Source of Existential Counseling Intervention

Bisma The Journal of Counseling
Many individuals experience confusion regarding the meaning and purpose of life due to the pressure of social comparison, making it difficult for them to fully understand themselves. This study aims to analyze the existential values in the novel Seporsi
Rahmawati, Budi Purwoko, Evi Winingsih, Bakhrudin All Habsy   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Preferred sources of meaning in life amongst preservice teachers from Generation Z: an exploratory qualitative study

Cogent Education
In emerging adulthood, especially among university students, the search for meaning in life is a significant existential concern. This study investigates whether there are differences in preferences for sources of life meaning between preservice teachers
Ivo Jirásek, Beáta Deutscherová, Juraj Obonya, Miroslava Jirásková, Anna Tirpáková   +4 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The Architecture of Existential Health: Toward a phenomenology of meaning, mortality and human flourishing

Contemporary models of well-being remain incomplete because they overlook the existential dimension. Drawing on philosophy, phenomenology, anthropology, sociology and public health, this article proposes existential health as a fourth domain of human ...
Jim Palmer
core   +1 more source

Cosmic Existentialism: Existence in an Indifferent Universe

Philosophies
The problem of meaning in an apparently indifferent universe has long been a central concern of existential philosophy. Classical existentialism addressed this question by emphasizing human freedom, responsibility, and the creation of meaning in the ...
Eduardo Duque-Dussán
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source