Results 51 to 60 of about 25,750 (260)

Would you exchange your soul for immortality?-existential meaning and afterlife beliefs predict mind upload approval. [PDF]

open access: yesFront Psychol, 2023
Laakasuo M   +6 more
europepmc   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Making existential meaning in transition to motherhood-A scoping review

open access: yes, 2014
Objective: To provide a thematic overview of the existing literature on existential meaning-making related to transition to motherhood among mothers of full term born babies in Western oriented countries and to discuss the themes from a existential ...
Prinds, Christina; id_orcid   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Russian verbs BYT’ and BYVAT’: existential and non‑existential meanings [PDF]

open access: yes, 2020
Two Russian verbs with existential meaning are compared – byt’ and byvat’. The verb byt’ “to be” is the main existential verb in Russian: collocations existential sentences and existential verbs are translated into Russian as bytijnye predloženia “existential sentences” and bytijnye glagoly “existential verbs.” The verb byt’ is ambiguous.
openaire   +1 more source

On the structure and meaning of NPs in Turkish existentials

open access: yes, 2022
This paper analyzes the structural and interpretive properties of Noun Phrases (NPs henceforth) in Turkish existential sentences. There are three different types of NPs, namely bare NPs, singular indefinite NPs and plural indefinite NPs, that can appear in existential structures.
Görgülü, Emrah, Görgülü, Emrah
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

ATTITUDE OF EXISTENTIALISM ABOUT "EXISTENTIAL DYING" AND ITS HUMANISTIC MEANING

open access: yesHue University Journal of Science: Social Sciences and Humanities, 2019
Existentialism is the philosophy of attitudes, a step away from traditional philosophy. The stance of existentialism of "dying" is one of those attitudes. Dying is a process by which the subject loses subjectivity, leading to a loss of personality due to the disparity between material life and the spiritual life that people do not recognize.
Nguyễn Tiến Dũng   +1 more
openaire   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

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