Results 51 to 60 of about 15,271 (203)

Matriptase deletion initiates a Sjögren's syndrome-like disease in mice. [PDF]

PLoS ONE, 2014
The objective of this study was to determine the effect of epithelial barrier disruption, caused by deficiency of the membrane-anchored serine protease, matriptase, on salivary gland function and the induction of autoimmunity in an animal model.Embryonic
Hongen Yin, Peter Kosa, Xibao Liu, William D Swaim, Zhennan Lai, Javier Cabrera-Perez, Giovanni Di Pasquale, Indu S Ambudkar, Thomas H Bugge, John A Chiorini   +9 more
doaj   +1 more source

Immune Markers and Risk of Pancreatic Cancer in the European EPIC Cohort

International Journal of Cancer, EarlyView.
The immune system has been implicated as a major driver in pancreatic cancer etiology. Previous cohort studies have found associations between pancreatic cancer and single immune system‐derived markers, but omics‐based evidence remains scarce. In this prospective case–control study, the authors investigated 92 proteins involved in immune reactions and ...
Verena A. Katzke, Yue Chen, Srimanti Dutta, Federico Canzian, Julie Louise Munk Andersen, Agnetha Linn Rostgaard‐Hansen, Léa Bouteille, Vinciane Rebours, Thérèse Truong, Matthias B. Schulze, Benedetta Bendinelli, Valeria Pala, Vittorio Simeon, Rosario Tumino, Carlotta Sacerdote, Roel Vermeulen, P. Martijn Kolijn, Sjoerd G. Elias, Marta Crous‐Bou, Maria‐José Sánchez, Ana Jimenez‐Zabala, José María Huerta, Marcela Guevara, Nick Wareham, Marie Breeur, Mattias Johansson, James Yarmolinsky, Daniele Campa, Rudolf Kaaks   +28 more
wiley   +1 more source

Gene expression signatures from single‐cell transcriptomics predict Sjögren's syndrome

iMetaOmics, EarlyView.
A machine learning‐based 12‐gene signature (SjS.Sig) was developed from scRNA‐seq data of PBMCs from Sjögren's syndrome patients. The model was validated using bulk RNA‐seq datasets and further confirmed through flow cytometry and qPCR analysis in an independent clinical cohort, demonstrating robust diagnostic potential.
Shumin Cheng, Ling Yan, Yilin Wu, Yan Li, Ziheng Ye, Zhen Zhang, Yi Zhang, Jingyun Ma, Yuhong Liang, Zhaofan Luo, Huacheng Wang, Meili Gao, Chao Qin, Ke Zhu, Yun Leng, Kamran Ullah, Jun Liang, Haiyan Yan, Guan Yang, Yingqian Mo, Bihui Huang   +20 more
wiley   +1 more source

Morphology of the Prosternal Glands of Heliconius erato (Lepidoptera: Nymphalidae)

Psyche: A Journal of Entomology, 2010
Two types of exocrine glands, located midventrally on the prosternum, are described for the larval stage of Heliconius erato (Linnaeus) (Lepidoptera: Nymphalidae).
Eliane de Oliveira Borges, Maria Cristina Faccioni-Heuser, Gilson Rudinei Pires Moreira   +2 more
doaj   +1 more source

An in vivo study of the effects on serum glucose, amylase and histopathology of the feline pancreatic tissue treated by focused ultrasound. [PDF]

PLoS ONE, 2014
Pancreatic cancer is one of the most malignant neoplasms originating in the digestive system. Focused ultrasound (FUS) treatment instead of the surgery operation has been used to treat Pancreatic cancer noninvasively in clinical trials. The endocrine and
Ying Mao, Liaoqiong Fang, Liang Ai, Chongyan Li, Zhibiao Wang, Junru Wu, Jin Bai, Faqi Li   +7 more
doaj   +1 more source

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, EarlyView.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source

GASTROINTESTINAL INVOLVEMENT IN SJÖGREN’S DISEASE

Rheumatology Quarterly
Sjögren’s syndrome (SjS) is a chronic autoimmune disorder characterized by lymphocytic infiltration of the exocrine glands, which can also affect the gastrointestinal (GI) tract, hepatobiliary system, and pancreatic exocrine tissues.
Fuat Albayram, Elif İnanç, Servet Yolbaş, Yahya Atayan   +3 more
doaj   +1 more source

Assessment of Gold‐Mediated Male Reproductive Dysfunction in Male WISTAR Rats Through Sperm Analysis and Testosterone Measurement

Journal of Applied Toxicology, EarlyView.
ABSTRACT Gold has been used for centuries in both ornamental and medicinal contexts. More recently, gold compounds, containing ions or nanoparticles, have attracted attention for their anti‐inflammatory, anticancer, and diagnostic applications. Therefore, concerns about systemic toxicity and biodistribution have prompted investigations into the ...
Samira Maghraoui, Adrian Florea, Leila Tekaya   +2 more
wiley   +1 more source

Incidence and Determinants of Steatotic Liver Disease after Pancreaticoduodenectomy: A Systematic Review and Meta‐Analysis

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Steatotic liver disease (SLD) is an unrecognized complication after pancreaticoduodenectomy (PD) and may affect nutrition and long‐term recovery. This meta‐analysis estimated the incidence of SLD after PD and identified its clinical and surgical risk factors.
Ronnakorn Kongsakon, Wasit Wongtrakul, Khemajira Karaketklang, Nonthalee Pausawasdi, Phunchai Charatcharoenwitthaya   +4 more
wiley   +1 more source

Sjögren’s syndrome: comparison among the main imaging techniques in the study of major salivary glands

Reumatismo, 2011
Sjögren’s syndrome (SS) is a chronic inflammatory disease with an autoimmune etiology, that affects exocrine glands, in particular salivary and lacrimal glands. Among the diagnostic criteria of SS, imaging tecniques play an important role. The aim of our
R. Gerli, G. Valesini, A. Iagnocco, C. Contessa, C. Campana, A. Dorigo, P. Zucchetta, M. Andretta, M. Carotti, F. Salaffi, R. Ramonda, P. Frallonardo, W. Grassi, L. Punzi   +13 more
doaj   +1 more source