Results 61 to 70 of about 314,408 (190)

Cystic Fibrosis and Colorectal Cancer Risk: Reprogramming of the Intestinal Epithelial Niche and Cell‐State Plasticity in the CFTR Modulator Era

Cell Proliferation, EarlyView.
In cystic fibrosis disorder, CFTR dysfunction drives multilayered intestinal niche disruption, including dysbiosis, inflammation, hypoxia, metabolic stress and genotoxic injury, promoting cell‐state plasticity and a pre‐neoplastic ecosystem. CFTR modulators and environmental factors may partially reshape these processes, highlighting opportunities for ...
Bala Umashankar, Ines Pankonien, Margarida Amaral, Chee Y. Ooi, Thierry Jardé, Shafagh A. Waters   +5 more
wiley   +1 more source

Pancreatic Exocrine Insufficiency in Patients With Pancreatic or Periampullary Cancer: A Systematic Review

, 2016
The aim of this study was to determine the prevalence of pancreatic exocrine insufficiency in patients with pancreatic or periampullary cancer, both before and after resection.
van Eijck, Casper H., Tseng, Dorine S. J., Besselink, Marc G., Borel Rinkes, Inne H., Molenaar, I. Quintus, van Santvoort, Hjalmar C.   +5 more
core   +2 more sources

What Are Computer‐Assisted Methods Achieving in Fine‐Needle Aspiration Cytology of the Pancreas? A Systematic Review and Meta‐Analysis

Cytopathology, EarlyView.
This meta‐analysis demonstrates high diagnostic accuracy of computer‐assisted methods in pancreatic EUS‐FNA cytology (AUC 0.92–0.96) and supports an integrated, cytopathologist‐led workflow in which artificial intelligence functions as an adjunct to diagnostic interpretation and on‐site evaluation (ROSE). Created in BioRender. Mohamed Mirzan, A. (2026)
Al‐Amaan Mohamed Mirzan, Roberto Dina
wiley   +1 more source

Associations between prior wasting malnutrition and indices of insulin secretion and sensitivity among six cohorts from Asia and Africa: The SAMPA study

Diabetic Medicine, EarlyView.
Abstract Aims The role of prior wasting malnutrition (PM) in determining insulin sensitivity and secretion in low‐ and middle‐income countries (LMICs) remains unclear. We investigated associations of insulin indices with PM and whether these were modified by current body mass index (BMI).
Sharon E. Cox, Sana Ahmed, Dixi Paglinawan Modoc, Riddhi Dasgupta, Christina Christoffersen, Molly Chisenga, Julius Patrick Ferrer, Ruth Frikke‐Schmidt, Rikke Krogh‐Madsen, Belinda Kweka, Nanette Lee, Evangelista Malindisa, Mizinga J. Tembo, Patrick Ngoya, Dorothea Nitsch, Daniel Faurholt‐Jepsen, George PrayGod, Geeta Trilok‐Kumar, Suzanne Filteau, James A. M. Shaw   +19 more
wiley   +1 more source

Investigation of lipid digestion by fungal and porcine lipase supplementation for severe pancreatic insufficiency using the in vitro dynamic TIM model

Heliyon
Background: Exocrine pancreatic insufficiency is caused by insufficient secretion or limited activity of pancreatic enzymes leading to inadequate food digestion.
Tânia Martins Garcia, Annet Maathuis, Ronald Schilderink, Ioannis Vrasidas, Alexander Iphöfer, Meinolf Wonnemann, Bartosz Lipowicz   +6 more
doaj   +1 more source

Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance

Immunology, EarlyView.
Central tolerance is shaped not merely by promiscuous gene expression in medullary thymic epithelial cells (mTECs), but by the subset of self‐peptides ultimately presented on MHC class II molecules. We propose a multilayered framework in which AIRE/Aire and FEZF2/Fezf2, together with specialised differentiation programmes—including thymic mimetic‐cell ...
Geraldo Aleixo Passos, Vitor Marcel Faça, Eduardo Antonio Donadi, Ana Paula Masson, Carlos Crippa Coletto, Gustavo Ronconi Roza   +5 more
wiley   +1 more source

Recurrent acute pancreatitis caused by a duodenal diverticulum: The diagnostic value of secretin‐enhanced magnetic resonance cholangiopancreatography

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Dagmar H. Zeef, Roy S. Dwarkasing, Annick S. Devos, Wim J. Lammers, Conny J. H. M. Meeussen, Marjolein van Waas   +5 more
wiley   +1 more source

The mediating role of genes in the influence of intestinal flora on type 2 diabetes and the screening of diagnostic markers

Journal of Diabetes Investigation, EarlyView.
Using Mendelian randomization, TWAS/eQTL analysis, machine learning, and single‐cell RNA sequencing, this study identified gut microbiota taxa causally linked to type 2 diabetes, candidate mediator genes, and diagnostic markers (BEND7, BLVRA, C1orf85, and LAMC1).
Yu‐yang Chen, Yi‐fan Shi, Xin‐yue Zhang, Jing‐yue Zhang, Shi‐mao Zhang, Heng‐xia Zhao, De‐liang Liu   +6 more
wiley   +1 more source

[Pancreatic exocrine insufficiency after acute pancreatitis].

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru, 2022
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Nombera Aznarán, Natalia Roxana, Guevara Lazo, David Rafael, Llontop Silva, Victor Manuel   +2 more
openaire   +2 more sources

Role of glucagon in metabolic diseases

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Currently, diabetes is defined as “a chronic hyperglycemic state resulting from the absolute or relative insufficiency of insulin action,” emphasizing its characterization as an insulin‐related disease. However, glucagon dysregulation should also play a critical role in the pathophysiology of type 2 diabetes.
Tadahiro Kitamura, Yoko Tabei, Masaki Kobayashi   +2 more
wiley   +1 more source