Results 71 to 80 of about 13,422 (192)

Multifaceted Roles of Chloroquines in Gastrointestinal Disorders and Beyond

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Chloroquine (CQ) and hydroxychloroquine (HCQ) modulate lysosomal activity and autophagy, suppressing gastrointestinal inflammation and reshaping pathogenic microbiota. These mechanisms alleviate inflammatory bowel disease, inhibit associated tumor growth, and provide benefits in certain autoimmune and viral conditions.
Sihyun Jeong, Eunsoo Kim, Yong Sung Kim, Eunok Im   +3 more
wiley   +1 more source

Loss of function variants in the primate-specific gene ZNF808 cause neonatal, transient and adult-onset diabetesResearch in context

EBioMedicine
Summary: Background: Biallelic loss-of-function ZNF808 variants were recently identified as a cause of pancreatic agenesis characterised by insulin-treated permanent neonatal diabetes (PNDM), low birthweight and exocrine pancreatic insufficiency ...
James Russ-Silsby, Kevin Colclough, Matthew B. Johnson, Matthew N. Wakeling, Nick D.L. Owens, Shenali A. Amaratunga, Sarah E. Flanagan, Kashyap A. Patel, Andrew T. Hattersley, Elisa De Franco, Mohamed Abdullah, Hessa Alkandari, Zehra Aycan, Semra Çetinkaya, Nancy Elbarbary, Radha Ghildiyal, Susana Gonzalez, Shaun Gorman, Samar Hassan, Savita Khadse, Jan Lebl, Jaida Manzoor, Nikhil Shah, Tara Hussein Tayeb, Alaa Al Assi, Arya Anil, Diego Balboa, Urvashi Chitnavis, Juliette Davis, Doga Eskier, Michael Imbeault, Santiago Morell, Sachin Muralidharan, Timo Otonkoski, Jonna Saarimäki-Vire   +34 more
doaj   +1 more source

Investigation of the Efficacy of Orientin in Streptozotocin‐Induced Type 1 Diabetes Model and Pancreatic Beta‐TC6 Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Orientin, a natural flavonoid, protects against streptozotocin‐induced pancreatic β‐cell damage by suppressing NF‐κB–mediated inflammation, restoring antioxidant defense (SOD, CAT, GSH), and inhibiting apoptotic (Bax/Bcl‐2, Caspase‐3/9) and pyroptotic (Caspase‐1, IL‐1β) cell death pathways in both an in vivo type 1 diabetes mouse model and Beta‐TC6 ...
Bengul Ozdemir Sarikaya, Seyit Ali Bingol   +1 more
wiley   +1 more source

Dynamic Prognostic Nutritional Index With Circulating Tumor DNA Predicts Survival in Localized Pancreatic Ductal Adenocarcinoma

Journal of Surgical Oncology, Volume 134, Issue 2, Page 272-281, August 2026.
ABSTRACT Background and Objectives To evaluate the prognostic significance of baseline and longitudinal changes in prognostic nutritional index (PNI) in localized pancreatic ductal adenocarcinoma (PDAC) and to assess the complementary prognostic value of PNI with tumor burden measured by circulating tumor DNA (ctDNA).
Alex Horowitz, Claire Shen, Dominic J. Vitello, Madison Cox, Amy Wells, Krishay Sridalla, David J. Bentrem, Qiang Zhang, Ishan Roy, Akhil Chawla   +9 more
wiley   +1 more source

Exocrine pancreatic insufficiency (EPI) in canine

Logos Ciencia & Tecnología, 2013
Exocrine pancreatic insufficiency is a syndrome characterized by bad digestion and poor absorption result of the failure of the secretion of pancreatic enzymes and other substances that facilitate the absorption of dietary nutrients and certain vitamins ...
Camilo Guarín Patarroyo, Fabian Rodrigo Sánchez Cuervo   +1 more
doaj  

High Methoxyl Pectin Consistently Reduces β‐Carotene Bioaccessibility Across Various Gastrointestinal Digestion Conditions

Molecular Nutrition &Food Research, Volume 70, Issue 15, 17 August 2026.
High methoxyl pectin (HMP) significantly reduced β‐carotene bioaccessibility in vitro. This was observed at various enzyme/bile concentrations and shear forces. ABSTRACT Dietary fiber could inhibit β‐carotene bioaccessibility by restricting its release from the food matrix, interfering with digestive enzyme activities, binding bile salts, or modifying ...
Anushka Shukla, Thomas Schleeh, Patrick Borel, Charles Desmarchelier, Torsten Bohn   +4 more
wiley   +1 more source

Addressing the distressing: Pancreatic enzyme replacement therapy mitigates abdominal symptoms and weight loss during chemotherapy for advanced pancreatic cancer: A prospective study

Nutrition in Clinical Practice, Volume 41, Issue 4, Page 1157-1165, August 2026.
Abstract Background Pancreatic enzyme insufficiency (PEI) contributes to symptom burden and malnutrition in advanced pancreatic cancer (aPC). We aimed to evaluate the impact of pancreatic enzyme replacement therapy (PERT) on symptom burden and weight during chemotherapy.
Pamela N. Klassen, Christina A. Kim, Jessica Kasnik, Michael B. Sawyer, Sunita Ghosh, Vickie Baracos, Vera C. Mazurak   +6 more
wiley   +1 more source

COMPARISON OF FECAL ELASTASE 1 FOR EXOCRINE PANCREATIC INSUFFICIENCY EVALUATION BETWEEN EX-ALCOHOLICS AND CHRONIC PANCREATITIS PATIENTS

Arquivos de Gastroenterologia, 2014
Context Fecal elastase is a noninvasive test for pancreatic insufficiency diagnosis. Objectives Evaluate the usefulness of fecal elastase 1 for the indication of exocrine pancreatic insufficiency among former alcohol addicts and patients with chronic ...
Rejane MATTAR, Gustavo André Silva LIMA, Marianges Zadrozny Gouvêa da COSTA, Joyce M Kinoshita SILVA-ETTO, Dulce GUARITA, Flair José CARRILHO   +5 more
doaj   +1 more source

Utilization of Des‐Gamma‐Carboxy‐Prothrombin in Estimating Vitamin K Status in People With Cystic Fibrosis: A Single Center Retrospective Review

Pediatric Pulmonology, Volume 61, Issue 8, August 2026.
ABSTRACT Background People with cystic fibrosis (CF) are at increased risk of fat‐soluble vitamin (A, D, E, and K) deficiencies secondary to exocrine pancreatic insufficiency (EPI). Estimation of vitamin K deficiency in routine clinical practice is challenging, and no uniform consensus exists due to lack of an accurate clinical test for the evaluation ...
Senthilkumar Sankararaman, Terri Schindler, Aravind Thavamani, Catherine Pamer, Alison Marie Rodatt, Kimberly A. McBennett, Erica Roesch, Alex H. Gifford   +7 more
wiley   +1 more source

GASTROINTESTINAL INVOLVEMENT IN SJÖGREN’S DISEASE

Rheumatology Quarterly
Sjögren’s syndrome (SjS) is a chronic autoimmune disorder characterized by lymphocytic infiltration of the exocrine glands, which can also affect the gastrointestinal (GI) tract, hepatobiliary system, and pancreatic exocrine tissues.
Fuat Albayram, Elif İnanç, Servet Yolbaş, Yahya Atayan   +3 more
doaj   +1 more source