Results 191 to 200 of about 153,788 (344)

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Protocol for the detection of large dense-core vesicle exocytosis using an automated image-processing algorithm. [PDF]

STAR Protoc
Makam A, Ramadas V, Tollan A, Bhattacharyya I, Dubey A, Gandasi NR.   +5 more
europepmc   +1 more source

71 Exocytosis of elastase-rich granules by live airway neutrophils correlates with PRAGMA CF score in early CF lung disease

, 2017
Hamed Horati, Camilla Margaroli, Bob J. Scholte, Mieke Veltman, Lina Peng, Harm A.W.M. Tiddens, R. Tirouvanziam, Hettie M. Janssens   +7 more
openalex   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Soma Ca²⁺ is decoupled from daily synaptic activity and neuropeptide release in Drosophila clock neurons. [PDF]

Curr Biol
Klose MK, Kim J, Gregg SN, Schmidt BF, Xia X, Li Y, Levitan ES.   +6 more
europepmc   +1 more source

Complexin 2 Modulates Vesicle-associated Membrane Protein (VAMP) 2-regulated Zymogen Granule Exocytosis in Pancreatic Acini [PDF]

, 2010
Michelle A. Falkowski, Diana D.H. Thomas, Guy E. Groblewski   +2 more
openalex   +1 more source

TRPM3 activation causes CGRP release in trigeminal neurons: Implications for migraine mechanisms

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Background The transient receptor potential melastatin 3 (TRPM3) ion channel has been implicated in sensory modulation and pain transmission and may contribute to migraine pathophysiology through calcitonin gene‐related peptide (CGRP) release in the trigeminovascular system. This study aimed to investigate TRPM3 activation and its role in CGRP
Philip V. Reducha, Lukas K. S. Nielsen, Mette N. Jensen, Jacob C. A. Edvinsson, Spyridoula Kazantzi, Sofia L. Wæver, Tanja Lylloff, Connar S. J. Westgate, Lars Edvinsson, Kristian A. Haanes   +9 more
wiley   +1 more source

Deep learning detection of dynamic exocytosis events in fluorescence TIRF microscopy. [PDF]

PLoS Comput Biol
Lachuer H, Moebel E, Macé AS, Masson A, Schauer K, Kervrann C.   +5 more
europepmc   +1 more source

Porosome: a membrane microdomain acting as the universal secretory portal in exocytosis [PDF]

, 2014
Mircea Leabu, Cristina Niculiţe
openalex   +1 more source

scRNA‐Seq reveals anti‐lymphoma immune responses in mogamulizumab‐associated skin eruptions

Journal of the European Academy of Dermatology and Venereology, EarlyView.
CCR4 was expressed in malignant clones and regulatory T cells in untreated CTCL, that were decreased in MAR. Malignant clones in MAR showed a silenced phenotype with decreases in central memory markers SELL and CCR7, and GTP‐binding member GIMAP7 and upregulation of MMP2 inhibitor TIMP2 and tumour suppressor gene RUNX3.
Shannon Meledathu, Agata Kurowski, Malini P. Naidu, Jonas Adalsteinsson, Shane A. Meehan, Natalia Alkon, Lauren R. Port, Sumanth Chennareddy, Emry R. Cohenour, Grace Christensen, Jonah Shulman, Nicholas Gulati, Constanze Jonak, Patrick M. Brunner   +13 more
wiley   +1 more source