Results 61 to 70 of about 394,574 (252)

Single Nucleotide Polymorphisms: A Deep Consideration of Protein Sequence Variation [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd
Introduction: Human genome consists of the three billion base pairs that has about one percent of genetic variation from one person to another، which determines physical، psychological، and susceptibility to diseases. Among the types of genetic diversity,
Majid Marzban Sarnaghi, Deniz Farzad, Reza Gholikhani Darbroud, Zafar Gholinejad   +3 more
doaj  

Curcumin at the Nanoscale: Formulation Strategies and Mechanistic Advances for Cancer Therapy

Exon
Curcumin is a potent anticancer agent, however, its clinical effectiveness is limited by poor solubility, low bioavailability, and rapid metabolic degradation. Recent advances in nanotechnology have led to the development of carrier-free nanocurcumin (NC)
Saad Ahmed, Aneela Shabbir
doaj   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Implementing One Health approach to emerging zoonotic diseases: Bridging surveillance, sustainability and global governance

Exon
The One Health approach offers a pragmatic and policy-relevant framework that integrates human, animal, and environmental health systems to confront the rising threat of zoonotic diseases.
Kingsley Excel Dunga, Chinyere Ihuarulam Okoro, Amarachi Chisom Onyenama, Uchechukwu Onyeukwu Ekuma, Irene Nneka Ohanusi, Sylvester Chibueze Izah   +5 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Nanotechnology and Biotechnology Against Multidrug-Resistant Pathogens: Promises and Challenges

Exon
The escalating threat of multidrug-resistant (MDR) pathogens necessitates innovative strategies that transcend conventional antibiotic paradigms. This review explores the transformative potential of integrating nanotechnology and biotechnology to address
Saad Ahmed
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

In vitro Antibacterial Activity and Phytochemical Profiling of Selected Medicinal Plants

Exon
This study aimed to investigate the phytochemical composition and antimicrobial activity of five Indian medicinal plants: Azadirachta indica, Mangifera indica, Ocimum tenuiflorum, Solanum trilobatum, and Piper betle, which were selected for their ...
Mohamed Shafil S, R Sriram, Syed Raffic Ali S, Md. Azmathullah N, Ghani Basha K, Sultan Mohideen A. K   +5 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Phenological Variations and Pharmacological Properties of Cassia Fistula: A Review of Environmental and Therapeutic Dimensions

Exon
The golden shower tree, Cassia fistula, is a botanical symbol of persistence, providing aesthetic appeal and sophisticated ecological dynamics. As the climate change specter looms, this paper delves into the delicate interplay between changing climatic ...
Shiva S, Vundrala Sumedha Reddy, Vishnu Vijay Kumar, Sharan Chandran M, G Sivasubramanian   +4 more
doaj   +1 more source