Results 91 to 100 of about 12,706 (198)
Insect Science, EarlyView.The Australian giant wood moth (Endoxyla cinereus) feeds within the galls of scale insects (Apiomorpha) before transitioning into its wood‐boring eucalypt larval phase. This transitionary phase may be key to its multi‐year development, at the end of which it can produce over 100 000 eggs.
Jessa H. Thurman +4 more
wiley +1 more source
A novel CRISPR/Cas9 associated technology for sequence-specific nucleic acid enrichment.
PLoS ONE, 2019 Massively parallel sequencing technologies have made it possible to generate large quantities of sequence data. However, as research-associated information is transferred into clinical practice, cost and throughput constraints generally require sequence ...
Richard C Stevens +9 more
doaj +1 more source
Extraocular Photoreception in Optic Lobes, Suckers, and Skin of Octopus vulgaris
Integrative Zoology, EarlyView.Evidence of extra‐ocular photoreception in Octopus vulgaris (a) Diagram of the O. vulgaris different tissues considered: SPB, sucker proximal big; SPL, sucker proximal large; SM, sucker medium; SD, sucker distal; SK, skin; OL, optic lobes; RT, retina; (b‐d) Gene expression analysis of Ov‐GRK1 (red), Ov‐retinochrome (green), Ov‐rhodopsin (blue) mRNA ...
Valeria Maselli +7 more
wiley +1 more source
Integrated Multi‐Omics Analysis Reveals the Genetic Basis of Phenotypic Variation in Tibetan Sheep
Integrative Zoology, EarlyView.SNaPshot‐validated GWAS results demonstrated significant correlations between candidate single nucleotide polymorphisms (SNPs) and body size traits in Tibetan sheep. Concurrently, hematoxylin and eosin staining, alongside muscle fiber analysis, confirmed pronounced morphological differences in muscle tissue between sheep of varying conformation.
Dehui Liu +16 more
wiley +1 more source
, 2010 Replication of the Escherichia coli chromosome usually initiates at a single origin (oriC) under control of DnaA. Two forks are established and move away in opposite directions.
Christian J Rudolph +3 more
core +1 more source
Integrative Zoology, EarlyView.Here, we adopt an integrative framework (molecular phylogenetics and geometric morphometrics) to reassess patterns of diversity and differentiation across this region. We analyzed cytochrome b sequences and quantified cranial shape variation. Our analyses indicate the presence of three species groups (mendocinus, talarum, and tucumanus) and two ...
Facundo Contreras +4 more
wiley +1 more source
Synthetic Strategies for Linear and Circular RNA
SynBioSynthetic RNA has become an essential modality in therapeutic development. Linear mRNA is already clinically validated, which demonstrated that in vitro-transcribed (IVT) RNA can achieve robust protein expression in humans and can be manufactured at a ...
Shi Du, Yuxi Zhu
doaj +1 more source
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
Cas4 and host exonucleases such as DinG facilitate adaptation in type I-C CRISPR-Cas systems
, 2022 To rapidly respond to threat by foreign mobile genetic elements, bacteria have evolved various immune mechanisms, one of which is the RNA-guided CRISPR-Cas (clustered regularly interspaced short palindromic repeats) system.
Suresh, Shravanti
core +1 more source
The nuclease EXO1 promotes genomic instability by degrading nascent DNA in BRCA-proficient cells
Nature CommunicationsDNA repair genes are generally considered tumor suppressors, as their inactivation is observed in tumors and is associated with carcinogenesis. Mutations in BRCA1 and BRCA2 genes are observed in breast, ovarian, and other cancers.
Alexandra Nusawardhana +2 more
doaj +1 more source