Results 91 to 100 of about 18,714 (239)

A short splicing isoform of HBS1L links the cytoplasmic exosome and SKI complexes in humans. [PDF]

, 2016
The exosome complex is a major eukaryotic exoribonuclease that requires the SKI complex for its activity in the cytoplasm. In yeast, the Ski7 protein links both complexes, whereas a functional equivalent of the Ski7 has remained unknown in the human ...
Chlebowski, Aleksander, Cysewski, Dominik, Dziembowski, Andrzej, Kalisiak, Katarzyna, Kowalska, Katarzyna, Kuliński, Tomasz M., Pietras, Zbigniew, Tomecki, Rafał   +7 more
core   +1 more source

Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Ma et al. report the hippocampal and hepatic acetylcholine (ACh) levels are differently modulated by regular versus irregular exercise, which contributes to coordinate hippocampal astrocyte activity and hepatic FBXL6high neutrophil recruitment. This ACh‐modulated brain‐liver circuit links the effects of exercise on fear memory extinction and liver ...
Pengjiao Ma, Kuan Zhang, Long Yi, Chuanyan Yang, Hedong Lang, Jianbin Sun, Jin Li, Qian Bai, Yuhang He, Shuang‐Shuang Dai, Man‐Tian Mi   +10 more
wiley   +1 more source

Substrate Recognition and Catalysis by the Exoribonuclease RNase R [PDF]

Journal of Biological Chemistry, 2006
RNase R is a processive, 3' to 5' hydrolytic exoribonuclease that together with polynucleotide phosphorylase plays an important role in the degradation of structured RNAs. However, RNase R differs from other exoribonucleases in that it can by itself degrade RNAs with extensive secondary structure provided that a single-stranded 3' overhang is present ...
Helen A, Vincent, Murray P, Deutscher
openaire   +2 more sources

Evolutionarily conserved 5'-3' exoribonuclease Xrn1 accumulates at plasma membrane-associated eisosomes in post-diauxic yeast. [PDF]

PLoS ONE, 2015
Regulation of gene expression on the level of translation and mRNA turnover is widely conserved evolutionarily. We have found that the main mRNA decay enzyme, exoribonuclease Xrn1, accumulates at the plasma membrane-associated eisosomes after glucose ...
Tomas Grousl, Miroslava Opekarová, Vendula Stradalova, Jiri Hasek, Jan Malinsky   +4 more
doaj   +1 more source

Identification of Genes Potentially Regulated by Human Polynucleotide Phosphorylase (hPNPaseold-35) Using Melanoma as a Model [PDF]

, 2013
Human Polynucleotide Phosphorylase (hPNPaseold-35 or PNPT1) is an evolutionarily conserved 3′→5′ exoribonuclease implicated in the regulation of numerous physiological processes including maintenance of mitochondrial homeostasis, mtRNA import and aging ...
Bacolod, Manny D., Das, Swadesh K., Dasgupta, Santanu, Emdad, Luni, Sokhi, Upneet K.   +4 more
core   +2 more sources

Five‐Year (2017–2022) Evolutionary Dynamics of Human Coronavirus OC43 in Southern France Based on Whole Genome Next‐Generation Sequencing

Journal of Medical Virology, Volume 97, Issue 12, December 2025.
ABSTRACT HCoV‐OC43 genomes and their evolution are scarcely studied worldwide and in France, with only 361 genomes available as of October 2023. Here, an in‐house PCR amplification system was implemented to obtain retrospectively by next‐generation sequencing, then analyze HCoV‐OC43 genomes for infections diagnosed with this virus in southern France ...
Hikmat Houmadi, Céline Boschi, Marine Lefebvre, Lorlane Le Targa, Justine Py, Jean‐Christophe Lagier, Lucile Lesage, Jacques Fantini, Aurélie Morand, Bernard La Scola, Philippe Colson   +10 more
wiley   +1 more source

The 3’-5’ exoribonuclease Dis3 regulates the expression of specific microRNAs in Drosophila wing imaginal discs [PDF]

, 2015
Dis3 is a highly conserved exoribonuclease which degrades RNAs in the 3'-5' direction. Mutations in Dis3 are associated with a number of human cancers including multiple myeloma and acute myeloid leukaemia.
Benjamin P Towler, Cecilia M Arraiano, Christopher I Jones, Joseph A Waldron, Patricia Apura, Sandra C Viegas, Sarah F Newbury, Sarah K Smalley, Sullivan W   +8 more
core   +2 more sources

Molecular Characterization of the Group A Streptococcus Virulence‐Regulatory System FasBCAX

Molecular Microbiology, Volume 124, Issue 6, Page 521-537, December 2025.
The Fas system of the group A Streptococcus is comprised of three proteins (FasBCA) and a small regulatory RNA (FasX), and it represses adhesin production while also promoting the production of the spreading factor streptokinase. Here, we analyze the Fas proteins to assess how they positively regulate FasX production.
Sushila Baral, Roshika Roshika, Clay P. Renshaw, Ameya Singh, Ashna Prabhu, Ira Jain, Rebekah Woolsey, David Quilici, Yftah Tal‐Gan, Paul Sumby   +9 more
wiley   +1 more source

Disruption of Zika Virus xrRNA1-Dependent sfRNA1 Production Results in Tissue-Specific Attenuated Viral Replication

Viruses, 2020
The Zika virus (ZIKV), like other flaviviruses, produces several species of sub-genomic RNAs (sfRNAs) during infection, corresponding to noncoding RNA fragments of different lengths that result from the exonuclease degradation of the viral 3 ...
Hadrian Sparks, Brendan Monogue, Benjamin Akiyama, Jeffrey Kieft, J. David Beckham   +4 more
doaj   +1 more source

Impact of PNPase on the transcriptome of Rhodobacter sphaeroides and its cooperation with RNase III and RNase E

BMC Genomics, 2021
Background The polynucleotide phosphorylase (PNPase) is conserved among both Gram-positive and Gram-negative bacteria. As a core part of the Escherichia coli degradosome, PNPase is involved in maintaining proper RNA levels within the bacterial cell.
Daniel-Timon Spanka, Carina Maria Reuscher, Gabriele Klug   +2 more
doaj   +1 more source