Results 111 to 120 of about 6,830 (257)
Cell Reports, 2019 Summary: Cell-based studies of human ribonucleases traditionally rely on methods that deplete proteins slowly. We engineered cells in which the 3′→5′ exoribonucleases of the exosome complex, DIS3 and EXOSC10, can be rapidly eliminated to assess their ...
Lee Davidson +7 more
doaj
Elevated Wall Tension Leads to Reduced miR‐133a in the Thoracic Aorta by Exosome Release
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background Reduced miR‐133a was previously found to be associated with thoracic aortic (TA) dilation, as seen in aneurysm disease. Because wall tension increases with vessel diameter (Law of Laplace), this study tested the hypothesis that elevated ...
Adam W. Akerman +8 more
doaj +1 more source
The Mysterious World of Non‐Canonical Caps – What We Know and Why We Need New Sequencing Techniques
ChemBioChem, Volume 26, Issue 3, February 1, 2025.This review describes sophisticated methodologies such as LC–MS that enabled the identification of 5’ non‐canonical RNA caps and also surveys so far developed sequencing methods, evaluating their advantages and disadvantages. It emphasizes the need for developing new, reliable sequencing techniques to identify RNA types with non‐canonical caps enabling
Flaminia Mancini, Hana Cahova
wiley +1 more source
Heterozygous PNPT1 Variants Cause a Sensory Ataxic Neuropathy
European Journal of Neurology, Volume 32, Issue 2, February 2025.ABSTRACT Background Biallelic variants in polyribonucleotide‐nucleotidyltransferase‐1 (PNPT1) have been associated with a range of phenotypes from syndromic hearing loss to Leigh's syndrome. More recently, heterozygous variants in PNPT1, have been reported in three families with cerebellar ataxia and prominent sensory neuropathy.
Saif Haddad +10 more
wiley +1 more source
mRNAs of plants and green algae lack the m7G cap‐1 structure
New Phytologist, Volume 246, Issue 2, Page 396-401, April 2025.
Chen Xiao +7 more
wiley +1 more source
Dynamic Combinatorial Chemistry Unveils Nsp10 Inhibitors with Antiviral Potential Against SARS‐CoV‐2
Chemistry – A European Journal, Volume 31, Issue 4, January 17, 2025.This study investigates antiviral strategies targeting SARS‐CoV‐2 by disrupting the protein‐protein interactions of Nsp10 with Nsp14 and Nsp16, which are essential for viral survival. It employs target‐directed dynamic combinatorial chemistry for the identification and synthesis of inhibitors.
Ravindra P. Jumde +15 more
wiley +1 more source
The influence of exoribonucleases in the regulation of stress related small RNAs [PDF]
, 2015 De modo a poder colonizar um ser humano, a bactéria Escherichia coli tem de ser capaz de resistir tanto a condições de anaerobiose como a um pH de 2.
BRAVO, Afonso Martins
core
Looping forward: exploring R‐loop processing and therapeutic potential
FEBS Letters, Volume 599, Issue 2, Page 244-266, January 2025.R‐loops function as both regulators of gene expression, DNA repair, telomere maintenance or chromosome segregation, and as drivers of genome instability. This dual nature of these structures is coordinated by RNA/DNA/chromatin processing factors that safeguard the genome from detrimental R‐loop‐instigated DNA damage or cellular dysfunction ...
Kalliopi Stratigi +2 more
wiley +1 more source
Journal of Biological Chemistry, 2004 In plant mitochondria, transcription proceeds well beyond the region that will become mature 3′ extremities of mRNAs, and the mechanisms of 3′ maturation are largely unknown.
R. Perrin +7 more
semanticscholar +1 more source
mBio, 2017 Ribonucleases facilitate rapid turnover of RNA, providing cells with another mechanism to adjust transcript and protein levels in response to environmental conditions. While many examples have been documented, a comprehensive list of RNase targets is not
Gina C. Gordon +2 more
doaj +1 more source