Post‐transcriptional gene regulation by the exoribonuclease Pacman
The gene pacman (pcm) in Drosophila melanogaster encodes the exoribonuclease XRN1, which is highly conserved across eukaryotes and is the only known cytoplasmic exoribonuclease that degrades RNA in the 5’ – 3’ direction. Hypomorphic mutations to pacman have previously been shown cause developmental phenotypes, particularly during wing and thorax ...
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A Comparative Overview of the Role of Human Ribonucleases in Nonsense-Mediated mRNA Decay. [PDF]
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Elder JJH +3 more
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Diribonuclease activity eliminates toxic diribonucleotide accumulation. [PDF]
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Independent neofunctionalization of Dxo1 in <i>Saccharomyces</i> and <i>Candida</i> led to 25S rRNA processing function. [PDF]
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Discovery of Substituted 5-(2-Hydroxybenzoyl)-2-Pyridone Analogues as Inhibitors of the Human Caf1/CNOT7 Ribonuclease. [PDF]
Kaur I +3 more
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Carrot and stick: how RNase R contributes to function and destruction of the translation machinery. [PDF]
Paternoga H, Dimitrova-Paternoga L.
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