Results 91 to 100 of about 3,495 (190)
New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.SARS‐CoV2 Omicron and its substrains are still a critical global health issue and extremely contagious, even with widespread vaccination efforts. Hospitalizations and mortality rates linked to these variants are still prevalent. Current therapeutic options face challenges, including low effectiveness, suboptimal pharmacokinetics, and drug resistance ...
Frank Eric Tatsing Foka +1 more
wiley +1 more source
Physiologia Plantarum, Volume 178, Issue 2, March/April 2026.ABSTRACT Viral suppressors of RNA silencing (VSRs) are proteins that interfere with antiviral defense mechanisms and enhance infection. For plant viruses, VSRs can be encoded in viral genomes and satellite molecules and play an important role in the virus's life cycle and in overcoming host defenses.
Saumik Basu +7 more
wiley +1 more source
The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma. [PDF]
, 2001 The anti-PM/Scl autoantibodies are known to characterize a subset of autoimmune patients with myositis, scleroderma (Scl), and the PM/Scl overlap syndrome. The major autoantigens that are recognized by anti-PM/Scl autoantibodies are designated PM/Scl-100
Brouwer, R. +2 more
core
Advanced Science, Volume 13, Issue 8, 9 February 2026.Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu +13 more
wiley +1 more source
Interfering with nucleotide excision by the coronavirus 3’-to-5’ exoribonuclease
, 2022 Abstract Some of the most efficacious antiviral therapeutics are ribonucleos(t)ide analogs. The presence of a 3’-to-5’ proofreading exoribonuclease (ExoN) in coronaviruses diminishes the potency of many ribonucleotide analogs. The ability to interfere with ExoN activity will create new possibilities for control of SARS-CoV-2 infection ...
Chinthapatla, Rukesh +12 more
openaire +2 more sources
mBio, 2017 Ribonucleases facilitate rapid turnover of RNA, providing cells with another mechanism to adjust transcript and protein levels in response to environmental conditions. While many examples have been documented, a comprehensive list of RNase targets is not
Gina C. Gordon +2 more
doaj +1 more source
Polyadenylation of stable RNA precursors in vivo [PDF]
, 1998 Polyadenylation at the 3′ terminus has long been considered a specific feature of mRNA and a few other unstable RNA species. Here we show that stable RNAs in Escherichia coli can be polyadenylated as well.
Deutscher, Murray P +2 more
core +1 more source
Interplay of Exoribonucleases, Hfq and Small RNAs Structural Determinants in the Control of Gene Expression [PDF]
, 2012 Dissertation presented to obtain the Ph.D degree in BiologySmall non-coding RNAs (sRNAs) are regulatory molecules that typically are not translated into proteins.
Pobre, Vânia Sofia Fidalgo
core
An important role for RNase R in mRNA decay [PDF]
, 2005 mRNA decay is a major determinant of gene expression. In Escherichia coli, message degradation initiates with an endoribonucleolytic cleavage followed by exoribonuclease digestion to generate 5'-mononucleotides.
Cheng, Zhuan-Fen, Deutscher, Murray P
core +1 more source
Conserved mechanism of Xrn1 regulation by glycolytic flux and protein aggregation
HeliyonThe regulation of gene expression in eukaryotes relies largely on the action of exoribonucleases, evolutionarily conserved enzymes that digest decapped messenger RNAs in the 5’-3’ direction.
Satyendra Mondal +3 more
doaj +1 more source