Results 91 to 100 of about 4,940 (209)
State‐of‐the‐Art Strategies for Circular RNA in Cancers: Opportunity and Challenge
MedComm, Volume 7, Issue 2, February 2026.Overview of circular RNA in tumors. ABSTRACT Circular RNAs (circRNAs) are characterized by their covalently closed structure, remarkable stability, and precise spatiotemporal regulation, evolving from once‐overlooked transcriptional byproducts to pivotal molecular regulators.
Zehao Ding +6 more
wiley +1 more source
The 3’-5’ exoribonuclease Dis3 regulates the expression of specific microRNAs in Drosophila wing imaginal discs [PDF]
, 2015 Dis3 is a highly conserved exoribonuclease which degrades RNAs in the 3'-5' direction. Mutations in Dis3 are associated with a number of human cancers including multiple myeloma and acute myeloid leukaemia.
Benjamin P Towler +8 more
core +2 more sources
Cancer Science, Volume 117, Issue 2, Page 297-307, February 2026.R‐loops are three‐stranded nucleic acid structures whose dysregulation leads to genomic instability and cancer progression. This review summarizes the protein and lncRNA machineries that regulate R‐loop dynamics and discusses the therapeutic potential of targeting these pathways in cancer.
Miho M. Suzuki +3 more
wiley +1 more source
Exoribonuclease in nonstructural protein 14 (nsp14-ExoN) [PDF]
Science-Business eXchange, 2013 In vitro studies suggest nsp14-ExoN inhibitors could help sensitize coronaviruses to RNA mutagen therapeutics including ribavirin.
openaire +1 more source
Structural and functional studies of the decapping exoribonucleases [PDF]
Acta Crystallographica Section A Foundations and Advances, 2014 Recent studies showed that two homologous yeast proteins, Rai1 and Dxo1, function in a quality control mechanism to clear cells of incompletely 5' end-capped messenger RNAs (mRNAs). Rai1 possesses a novel decapping activity that can remove the entire cap structure dinucleotide from an mRNA.
Jeong Ho Chang, Liang Tong
openaire +1 more source
The role of ribonucleases in regulating global mRNA levels in the model organism Thermus thermophilus HB8 [PDF]
, 2014 BACKGROUND: RNA metabolism, including RNA synthesis and RNA degradation, is one of the most conserved biological systems and has been intensively studied; however, the degradation network of ribonucleases (RNases) and RNA substrates is not fully ...
Akeo Shinkai +7 more
core +1 more source
Human FASTK preferentially binds single‐stranded and G‐rich RNA
The FEBS Journal, Volume 293, Issue 3, Page 729-748, February 2026.Although FASTK is known to play a role in mRNA biology, the mechanism through which it recognizes RNA has yet to be unraveled. Here, we used purified human FASTK to characterize its RNA‐binding properties in vitro. We found that FASTK prefers ssRNA oligonucleotides containing guanines with the potential to form G‐quadruplexes and binds robustly to any ...
Daria M. Dawidziak +7 more
wiley +1 more source
Elevated Wall Tension Leads to Reduced miR‐133a in the Thoracic Aorta by Exosome Release
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background Reduced miR‐133a was previously found to be associated with thoracic aortic (TA) dilation, as seen in aneurysm disease. Because wall tension increases with vessel diameter (Law of Laplace), this study tested the hypothesis that elevated ...
Adam W. Akerman +8 more
doaj +1 more source
Nuclear RNA Surveillance in \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e: Trf4p-dependent Polyadenylation of Nascent Hypomethylated tRNA and an Aberrant Form of 5S rRNA [PDF]
, 2006 1-Methyladenosine modification at position 58 of tRNA is catalyzed by a two-subunit methyltransferase composed of Trm6p and Trm61p in Saccharomyces cerevisiae.
Anderson, James T. +2 more
core +1 more source
New Phytologist, Volume 249, Issue 3, Page 1219-1233, February 2026.Summary Chloroplast‐to‐nucleus retrograde signalling enables rapid stress responses in plants, but whether these signals accumulate to affect crop performance across entire growing seasons under field conditions remains unknown. We generated wheat mutants with targeted deletions in specific SAL gene copies from two distinct homeologous groups (TaSAL1 ...
Andrew F. Bowerman +13 more
wiley +1 more source