Results 101 to 110 of about 4,940 (209)

Exosomes: Looking back three decades and into the future [PDF]

, 2013
Exosomes are extracellular membrane vesicles whose biogenesis by exocytosis of multivesicular endosomes was discovered in 1983. Since their discovery 30 years ago, it has become clear that exosomes contribute to many aspects of physiology and disease ...
Alvarez-Erviti, Baietti, Bhatnagar, Bhatnagar, Ciechanover, Clifford V. Harding, Dautry-Varsat, Denzer, Hanson, Harding, Harding, Harding, Harding, Henne, Henne, Heuser, Heuser, Heuser, Hsu, Hurley, John E. Heuser, Klausner, Lippincott-Schwartz, Mitchell, Mittelbrunn, Ostrowski, Pan, Pan, Philip D. Stahl, Qu, Qu, Ramachandra, Raposo, Raposo, Savina, Savina, Segura, Silverman, Skog, Stahl, Théry, Théry, Tietze, Trajkovic, Trams, Valadi, van Bockxmeer, Vidal, Vincent-Schneider, Zitvogel   +49 more
core   +3 more sources

Chloroplast Fibrillin‐Mediated α‐Tocopherol Biosynthesis Impaired by a Virus to Enhance Infection and to Improve Drought Tolerance

Advanced Science, Volume 13, Issue 3, 14 January 2026.
ToCV‐encoded p22 targets chloroplast plastoglobules (PGs) via directly binding PG structural protein FBN1.1, reducing the size of PG and inhibiting α‐tocopherol biosynthesis via competing with tocopherol cyclase (VTE1). Consequently, the elevated chloroplast ROS not only creates a suitable cellular environment for efficient ToCV infection but also ...
Sijia Liu, Xuedong Liu, Qin Yan, Xi Chen, Lianyi Zang, Jingang Hu, Xiaoping Zhu, Zaifeng Fan, Tao Zhou   +8 more
wiley   +1 more source

Evolution of MIR159/319 microRNA genes and their post-transcriptional regulatory link to siRNA pathways [PDF]

, 2011
Background MicroRNAs (miRNAs) are prevalent and important endogenous gene regulators in eukaryotes. MiR159 and miR319 are highly conserved miRNAs essential for plant development and fertility.
Yang Li, Chaoqun Li, Guohui Ding, Youxin Jin   +3 more
core   +1 more source

The 5′ Cap Epitranscriptome and Beyond: Natural and Engineered 5′ Cap Modifications for Optimizing mRNA Therapeutics and Functional Studies

ChemMedChem, Volume 21, Issue 2, January 2026.
5′ Cap modifications can be introduced via enzymes or chemical synthesis. Natural and non‐natural 5′ cap structures affect mRNA properties, including translation (T), stability (S), and/or immunogenicity (I). Eukaryotic mRNAs made by in vitro transcription have emerged as medical modalities for vaccination and protein replacement therapy. The 5′ cap is
Greta Charlotte Dahm, Melissa Pieper, Helena Schepers, Andrea Rentmeister   +3 more
wiley   +1 more source

Certain Adenylated Non-Coding RNAs, Including 5′ Leader Sequences of Primary MicroRNA Transcripts, Accumulate in Mouse Cells following Depletion of the RNA Helicase MTR4 [PDF]

, 2014
RNA surveillance plays an important role in posttranscriptional regulation. Seminal work in this field has largely focused on yeast as a model system, whereas exploration of RNA surveillance in mammals is only recently begun.
Anderson, James T., Dorweiler, Jane E., Munroe, Stephen, Ni, Ting, Zhu, Jun   +4 more
core   +4 more sources

RNA Sequencing Identifies New RNase III Cleavage Sites in Escherichia coli and Reveals Increased Regulation of mRNA

mBio, 2017
Ribonucleases facilitate rapid turnover of RNA, providing cells with another mechanism to adjust transcript and protein levels in response to environmental conditions. While many examples have been documented, a comprehensive list of RNase targets is not
Gina C. Gordon, Jeffrey C. Cameron, Brian F. Pfleger   +2 more
doaj   +1 more source

Landscape of RNA polyadenylation in E-coli [PDF]

, 2016
Polyadenylation is thought to be involved in the degradation and quality control of bacterial RNAs but relatively few examples have been investigated.
Aurell, Erik, Gracia, Celine, Hajnsdorf, Eliane, Innocenti, Nicolas, Maes, Alexandre, Zhang, Kaiyang   +5 more
core   +3 more sources

A short splicing isoform of HBS1L links the cytoplasmic exosome and SKI complexes in humans. [PDF]

, 2016
The exosome complex is a major eukaryotic exoribonuclease that requires the SKI complex for its activity in the cytoplasm. In yeast, the Ski7 protein links both complexes, whereas a functional equivalent of the Ski7 has remained unknown in the human ...
Chlebowski, Aleksander, Cysewski, Dominik, Dziembowski, Andrzej, Kalisiak, Katarzyna, Kowalska, Katarzyna, Kuliński, Tomasz M., Pietras, Zbigniew, Tomecki, Rafał   +7 more
core   +1 more source

Polynucleotide phosphorylase has an impact on cell biology of Campylobacter jejuni [PDF]

, 2012
Polynucleotide phosphorylase (PNPase), encoded by the pnp gene, is known to degrade mRNA, mediating post-transcriptional regulation and may affect cellular functions. The role of PNPase is pleiotropic. As orthologs of the two major ribonucleases (RNase E
Christopher M. Burns, Didier Chevret, Hervé Prévost, Jean M. Cappelier, Katell Rivoal, Nabila Haddad, Odile Tresse, Quentin Nonglaton   +7 more
core   +3 more sources

Conserved mechanism of Xrn1 regulation by glycolytic flux and protein aggregation

Heliyon
The regulation of gene expression in eukaryotes relies largely on the action of exoribonucleases, evolutionarily conserved enzymes that digest decapped messenger RNAs in the 5’-3’ direction.
Satyendra Mondal, Jakub Zahumensky, Petra Vesela, Jan Malinsky   +3 more
doaj   +1 more source