Results 71 to 80 of about 4,940 (209)

Antivirals Targeting Coronavirus RNA‐Dependent RNA Polymerase and Main Protease: From Mechanisms of Action to Outcomes in COVID‐19 Clinical Trials

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
The target sites of COVID‐19 antivirals discussed in the present opinion paper, namely the RNA dependent RNA polymerase Nsp12 and of the main viral protease Nsp5, are indicated by a red star in the overview of the replication cycle of coronavirus SARS‐CoV‐2.
Harald Brüssow
wiley   +1 more source

Selective 2′-Hydroxyl Acylation Analyzed by Protection from Exoribonuclease [PDF]

Journal of the American Chemical Society, 2010
Selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE) is a powerful approach for characterizing RNA structure and dynamics at single-nucleotide resolution. However, SHAPE technology is limited, sometimes severely, because primer extension detection obscures structural information for ~15 nts at the 5′ end and 40–60 nts at the 3′ end of ...
Kady-Ann, Steen, Arun, Malhotra, Kevin M, Weeks   +2 more
openaire   +2 more sources

PPR Protein BFA2 Is Essential for the Accumulation of the atpH/F Transcript in Chloroplasts

Frontiers in Plant Science, 2019
As a fascinating and complicated nanomotor, chloroplast ATP synthase comprises nine subunits encoded by both the nuclear and plastid genomes. Because of its uneven subunit stoichiometry, biogenesis of ATP synthase and expression of plastid-encoded ATP ...
Lin Zhang, Wen Zhou, Liping Che, Jean-David Rochaix, Congming Lu, Wenjing Li, Lianwei Peng   +6 more
doaj   +1 more source

Haplotype‐phased ‘Ottawa 3’ genome unravels differential reaction of apple rootstock roots to mixed viral infection

The Plant Journal, Volume 126, Issue 1, April 2026.
SUMMARY Viral diseases pose a significant threat to global apple (Malus spp.) production. While selecting appropriate rootstocks is a crucial strategy to mitigate their effects, the underlying mechanisms governing rootstock tolerance or sensitivity to viral infection at the root level remain underexplored.
Larissa Carvalho Costa, Christopher Gottschalk, Davis M. Upchurch, Oscar P. Hurtado‐Gonzales, Ben N. Mansfeld, Alan Yocca, Lauren Whitt, Cheryl Vann, Gennaro Fazio   +8 more
wiley   +1 more source

Structural and biochemical insights into small RNA 3' end trimming by Arabidopsis SDN1. [PDF]

, 2018
A family of DEDDh 3'→5' exonucleases known as Small RNA Degrading Nucleases (SDNs) initiates the turnover of ARGONAUTE1 (AGO1)-bound microRNAs in Arabidopsis by trimming their 3' ends. Here, we report the crystal structure of Arabidopsis SDN1 (residues 2-
Cao, Chunyang, Chen, Jiayi, Chen, Xuemei, Gan, Jianhua, Gu, Jiaqi, Huang, Ying, Liu, Li, Ma, Jinbiao, Ruan, Wenjie, You, Chenjiang, Zhang, Lu   +10 more
core   +2 more sources

Evolution of Prime Editing: Enhancing Efficiency and Expanding Capacity

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Most rare diseases are caused by genetic mutations. Prime editing (PE) has emerged as a versatile tool capable of inducing diverse mutations without generating DNA double‐strand breaks. Despite its significant clinical potential, PE faces limitations in terms of efficiency and scalability.
Jihyeon Yu, Ju‐Chan Park, Heesoo Uhm, Yong‐Woo Kim, Hyeon Woo Im, Sangsu Bae   +5 more
wiley   +1 more source

A DIStinctively novel exoribonuclease that really likes U

The EMBO Journal, 2013
Regulated degradation plays a major role in determining the levels of both non-coding (miRNA) and coding (mRNA) transcripts. Thus, insights into the factors and pathways that influence this process have broad, interdisciplinary implications. New findings by Malecki et al (2013), Lubas et al (2013), and Chang et al (2013) identify the protein Dis3L2 as ...
Imed E, Gallouzi, Jeffrey, Wilusz
openaire   +3 more sources

Regulatory Mechanisms of Exoribonuclease PNPase and Regulatory Small RNA on T3SS of Dickeya dadantii

Molecular Plant-Microbe Interactions, 2010
The type III secretion system (T3SS) is an essential virulence factor for many bacterial pathogens. Polynucleotide phosphorylase (PNPase) is one of the major exoribonucleases in bacteria and plays important roles in mRNA degradation, tRNA processing, and
Quan Zeng, A. Mark Ibekwe, Eulandria Biddle, Ching-Hong Yang   +3 more
doaj   +1 more source

EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks [PDF]

, 2019
The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism. Here we show that the exosome is necessary for the repair of DNA double-strand breaks (DSBs) in human cells and that RNA clearance is an essential step in homologous ...
Bonath, Franziska, Domingo Prim, Judit, Endara Coll, Martin, Friedländer, Marc R., Huertas Sánchez, Pablo, Jimeno González, Sonia, Prados Carvajal, Rosario, Visa, Neus   +7 more
core   +2 more sources

Molecular Responses to Climate Change: How Warming and Acidification Reshape the Proteome and Phosphoproteome of the Endangered Mira Chub

Ecology and Evolution, Volume 16, Issue 3, March 2026.
ABSTRACT Global environmental change affects organisms, including their physiology. In freshwater ecosystems, where migration is limited, populations often rely on phenotypic plasticity to respond. While transcriptomics has been widely used to study stress responses at the molecular level, less is known about the proteome, which reflects post ...
João M. Moreno, Jonas Grossmann, Laura Kunz, Antje Dittmann, Vitor C. Sousa, Romana Santos   +5 more
wiley   +1 more source