Results 71 to 80 of about 3,495 (190)
Glia, Volume 74, Issue 5, May 2026.ZSWIM8, an E3 ubiquitin ligase that broadly targets IDR‐rich proteins, drives MiR‐7‐dependent AGO2 degradation and the turnover of many RBPs. Loss of ZSWIM8 leads to MiR‐7 accumulation in oligodendrocyte progenitor cells and myelination defects in the developing brain. ABSTRACT Proteostasis of proteins with intrinsically disordered regions (IDRs) is of
Jing Lei +13 more
wiley +1 more source
The exoribonuclease Xrn1 is a post-transcriptional negative regulator of autophagy [PDF]
Autophagy, 2018 Macroautophagy/autophagy is a conserved catabolic process that promotes survival during stress. Autophagic dysfunction is associated with pathologies such as cancer and neurodegenerative diseases. Thus, autophagy must be strictly modulated at multiple levels (transcriptional, post-transcriptional, translational and post-translational) to prevent ...
Elizabeth Delorme-Axford +7 more
openaire +3 more sources
Microbial Biotechnology, Volume 19, Issue 5, May 2026.Chemical structure of RIBOTAC inhibitor with metabolic handle binding as nucleotide analogue to SARS‐CoV‐2 RNA dependent RNA polymerase, its linker and the RNase L recruiter which binds RNase L monomers and mediates their dimerization that actives nuclease activity degrading the viral RNA.
Harald Brüssow
wiley +1 more source
Novel roles of sulfur metabolism in stress‐controlled stomata aperture regulation
New Phytologist, Volume 250, Issue 3, Page 1460-1467, May 2026.Summary Stomatal closure allows plants to conserve water by reducing transpiration during drought. Surprisingly, the assimilation of the macronutrient sulfur is intimately connected to the drought stress response. This Tansley insight will only briefly touch on the general impact of sulfate assimilation on the production of drought‐response metabolites.
Sheng‐Kai Sun +2 more
wiley +1 more source
The roles of the exoribonucleases DIS3L2 and XRN1 in human disease [PDF]
, 2020 RNA degradation is a vital post-transcriptional process which ensures that transcripts are maintained at the correct level within the cell. DIS3L2 and XRN1 are conserved exoribonucleases that are critical for the degradation of cytoplasmic RNAs. Although
Christopher I Jones +3 more
core
Functional and structural analysis of the C. elegans PAXT-1-XRN2 complex [PDF]
, 2015 XRN2 is an essential nuclear 5’ -> 3’ exoribonuclease that is involved in quality control, processing and degradation of RNAs, such as rRNA, snRNA and miRNAs. Recently, C. elegans XRN2 was discovered to exist in a stable complex with PAXT-1.
Richter, Hannes
core +1 more source
Regulatory Mechanisms of Exoribonuclease PNPase and Regulatory Small RNA on T3SS of Dickeya dadantii
Molecular Plant-Microbe Interactions, 2010 The type III secretion system (T3SS) is an essential virulence factor for many bacterial pathogens. Polynucleotide phosphorylase (PNPase) is one of the major exoribonucleases in bacteria and plays important roles in mRNA degradation, tRNA processing, and
Quan Zeng +3 more
doaj +1 more source
Advanced Science, Volume 13, Issue 19, 2 April 2026.We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang +10 more
wiley +1 more source
A DIStinctively novel exoribonuclease that really likes U
The EMBO Journal, 2013 Regulated degradation plays a major role in determining the levels of both non-coding (miRNA) and coding (mRNA) transcripts. Thus, insights into the factors and pathways that influence this process have broad, interdisciplinary implications. New findings by Malecki et al (2013), Lubas et al (2013), and Chang et al (2013) identify the protein Dis3L2 as ...
Imed E, Gallouzi, Jeffrey, Wilusz
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Elastic Coupling Between RNA Degradation and Unwinding by an Exoribonuclease [PDF]
Science, 2012 Loading a Spring To regulate cellular RNA levels, transcription must be balanced by RNA degradation. An important player is the exosome, which can unwind and degrade structured RNA. Lee et al. (p.
Gwangrog, Lee +4 more
openaire +2 more sources