Results 41 to 50 of about 6,810 (209)
Composition and conservation of the mRNA-degrading machinery in bacteria [PDF]
RNA synthesis and decay counteract each other and therefore inversely regulate gene expression in pro- and eukaryotic cells by controlling the steady-state level of individual transcripts.
Dharam Singh+2 more
core +4 more sources
A Subset of Exoribonucleases Serve as Degradative Enzymes for pGpG in c-di-GMP Signaling
The bacterial bis-(3′-5′)-cyclic dimeric GMP (c-di-GMP) signaling molecule regulates complex processes, such as biofilm formation. c-di-GMP is degraded in two-steps, linearization into pGpG and subsequent cleavage to two GMPs.
M. Orr+10 more
semanticscholar +1 more source
RNase J1 and J2 Are Host-Encoded Factors for Plasmid Replication
Plasmids need to ensure their transmission to both daughter-cells when their host divides, but should at the same time avoid overtaxing their hosts by directing excessive host-resources toward production of plasmid factors.
Vanessa Andrade Guimarães+10 more
doaj +1 more source
RNA Turnover: Unexpected Consequences of Being Tailed [PDF]
In eukaryotic cells, the 3′ poly(A) tails found on mRNA influence their stability and translation. The discovery of a second nuclear poly(A) polymerase complex has fueled a series of reports defining a new and unexpected role for 3′ end poly(A) tails in ...
Anderson, James T.
core +2 more sources
Defining the impact of exoribonucleases in the shift between exponential and stationary phases
The transition between exponential and stationary phase is a natural phenomenon for all bacteria and requires a massive readjustment of the bacterial transcriptome. Exoribonucleases are key enzymes in the transition between the two growth phases. PNPase,
V. Pobre+4 more
semanticscholar +1 more source
A novel role for the 3′-5′ exoribonuclease Dis3L2 in controlling cell proliferation and tissue growth [PDF]
In a complex organism, cell proliferation and apoptosis need to be precisely controlled in order for tissues to develop correctly. Excessive cell proliferation can lead to diseases such as cancer. We have shown that the exoribonuclease Dis3L2 is required
Benjamin P. Towler+5 more
core +2 more sources
Flaviviruses accumulate abundant subgenomic RNA (sfRNA) in infected cells. It has been reported that sfRNA results from stalling of host 5'-to-3' exoribonuclease XRN1 at the highly structured RNA of the 3' untranslated region (UTR).
Yi-Shiuan Chen+4 more
doaj +1 more source
Regulation of cytoplasmic RNA stability: lessons from drosophila [PDF]
The process of RNA degradation is a critical level of regulation contributing to the control of gene expression. In the last two decades a number of studies have shown the specific and targeted nature of RNA decay and its importance in maintaining ...
Abdelmohsen+164 more
core +1 more source
Composition and function of P bodies in Arabidopsis thaliana
mRNA accumulation is tightly regulated by diverse molecular pathways. The identification and characterization of enzymes and regulatory proteins involved in controlling the fate of mRNA offers the possibility to broaden our understanding of ...
Luis David Maldonado-Bonilla
doaj +1 more source
Structural and biochemical insights into small RNA 3' end trimming by Arabidopsis SDN1. [PDF]
A family of DEDDh 3'→5' exonucleases known as Small RNA Degrading Nucleases (SDNs) initiates the turnover of ARGONAUTE1 (AGO1)-bound microRNAs in Arabidopsis by trimming their 3' ends. Here, we report the crystal structure of Arabidopsis SDN1 (residues 2-
Cao, Chunyang+10 more
core +2 more sources