Results 41 to 50 of about 5,247 (188)

Composition and function of P bodies in Arabidopsis thaliana

open access: yesFrontiers in Plant Science, 2014
mRNA accumulation is tightly regulated by diverse molecular pathways. The identification and characterization of enzymes and regulatory proteins involved in controlling the fate of mRNA offers the possibility to broaden our understanding of ...
Luis David Maldonado-Bonilla
doaj   +1 more source

Modulating the RNA processing and decay by the exosome: altering Rrp44/Dis3 activity and end-product. [PDF]

open access: yesPLoS ONE, 2013
In eukaryotes, the exosome plays a central role in RNA maturation, turnover, and quality control. In Saccharomyces cerevisiae, the core exosome is composed of nine catalytically inactive subunits constituting a ring structure and the active nuclease ...
Filipa P Reis   +8 more
doaj   +1 more source

Mutagenesis analysis of the zinc-finger antiviral protein [PDF]

open access: yes, 2010
BACKGROUND: The zinc-finger antiviral protein (ZAP) specifically inhibits the replication of certain viruses, including murine leukemia virus (MLV), by preventing the accumulation of viral mRNA in the cytoplasm.
Fengxiang Lv, Guangxia Gao, Xinlu Wang
core   +2 more sources

Circular RNA as a Potential Biomarker for Forensic Age Prediction

open access: yesFrontiers in Genetics, 2022
In forensic science, accurate estimation of the age of a victim or suspect can facilitate the investigators to narrow a search and aid in solving a crime.
Junyan Wang   +8 more
doaj   +1 more source

Supporting Role for GTPase Rab27a in Hepatitis C Virus RNA Replication through a Novel miR-122-Mediated Effect. [PDF]

open access: yesPLoS Pathogens, 2015
The small GTPase Rab27a has been shown to control membrane trafficking and microvesicle transport pathways, in particular the secretion of exosomes. In the liver, high expression of Rab27a correlates with the development of hepatocellular carcinoma.
Tzu-Chun Chen   +2 more
doaj   +1 more source

The Exosome Subunit Rrp44 Plays a Direct Role in RNA Substrate Recognition [PDF]

open access: yes, 2007
The exosome plays key roles in RNA maturation and surveillance, but it is unclear how target RNAs are identified. We report the functional characterization of the yeast exosome component Rrp44, a member of the RNase II family.
Anderson, James T.   +2 more
core   +2 more sources

Mechanisms of action of cytoplasmic miRNAs. Part 4. Recruitment of the DCP1-DCP2 decapping complex. Mechanisms of final mRNA degradation

open access: yesZdorovʹe Rebenka, 2022
This scientific review deals with the mechanisms of action of cytoplasmic microRNAs, namely post-transcriptional silencing: recruitment of the DCP1-DCP2 decapping complex and disruption of the interaction of mRNA with ribosomes.
A.E. Abaturov, V.L. Babуch
doaj   +1 more source

Impact of alternative carbon sources and antifungal treatment on Candida glabrata biofilms transcription profile [PDF]

open access: yes, 2016
Candida glabrata is considered a major opportunistic fungal pathogen of humans and has emerged as a leading cause of nosocomial fungal infections. The capacity of this yeast species to cause infections is dependent on the ability to grow within the human
Alves, Rosana   +8 more
core   +1 more source

Identification of Genes Potentially Regulated by Human Polynucleotide Phosphorylase (hPNPaseold-35) Using Melanoma as a Model [PDF]

open access: yes, 2013
Human Polynucleotide Phosphorylase (hPNPaseold-35 or PNPT1) is an evolutionarily conserved 3′→5′ exoribonuclease implicated in the regulation of numerous physiological processes including maintenance of mitochondrial homeostasis, mtRNA import and aging ...
Bacolod, Manny D.   +4 more
core   +2 more sources

Photocaged Dinucleoside Tetraphosphates for Light‐Mediated Activation of 5′ Cap Interactions and Translation In Vitro

open access: yesChemistryEurope, EarlyView.
Photocaged dinucleoside tetraphosphates can be incorporated into mRNA by T7 RNA polymerase. Subsequent irradiation with light activates 5′ cap interactions and translation. These 5′ cap analogs are useful tools to probe the functions of naturally occurring dinucleoside tetraphosphates and their role in bacteria and mammalian cells.
Cedrik Kühling   +5 more
wiley   +1 more source

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