Results 71 to 80 of about 6,830 (257)
Zdorovʹe Rebenka, 2022 This scientific review deals with the mechanisms of action of cytoplasmic microRNAs, namely post-transcriptional silencing: recruitment of the DCP1-DCP2 decapping complex and disruption of the interaction of mRNA with ribosomes.
A.E. Abaturov, V.L. Babуch
doaj +1 more source
Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor. [PDF]
Commun BiolLockbaum GJ +21 more
europepmc +2 more sources
The exoribonuclease Xrn1 is a post-transcriptional negative regulator of autophagy [PDF]
Autophagy, 2018 Macroautophagy/autophagy is a conserved catabolic process that promotes survival during stress. Autophagic dysfunction is associated with pathologies such as cancer and neurodegenerative diseases. Thus, autophagy must be strictly modulated at multiple levels (transcriptional, post-transcriptional, translational and post-translational) to prevent ...
Elizabeth Delorme-Axford +7 more
openaire +4 more sources
Mutagenesis analysis of the zinc-finger antiviral protein [PDF]
, 2010 BACKGROUND: The zinc-finger antiviral protein (ZAP) specifically inhibits the replication of certain viruses, including murine leukemia virus (MLV), by preventing the accumulation of viral mRNA in the cytoplasm.
Fengxiang Lv, Guangxia Gao, Xinlu Wang
core +2 more sources
Structural and biochemical studies of the 5′→3′ exoribonuclease Xrn1 [PDF]
Nature Structural & Molecular Biology, 2011 The 5'→3' exoribonucleases (XRNs) have important functions in transcription, RNA metabolism and RNA interference. The structure of Rat1 (also known as Xrn2) showed that the two highly conserved regions of XRNs form a single, large domain that defines the active site of the enzyme.
Kehui Xiang +5 more
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A novel fry1 allele reveals the existence of a mutant phenotype unrelated to 5'->3' exoribonuclease (XRN) activities in Arabidopsis thaliana roots. [PDF]
PLoS ONE, 2011 Mutations in the FRY1/SAL1 Arabidopsis locus are highly pleiotropic, affecting drought tolerance, leaf shape and root growth. FRY1 encodes a nucleotide phosphatase that in vitro has inositol polyphosphate 1-phosphatase and 3',(2'),5'-bisphosphate ...
Judith Hirsch +17 more
doaj +1 more source
The FEBS Journal, Volume 292, Issue 11, Page 2715-2736, June 2025.The silencing of transposable elements is mediated by piRNAs through post‐transcriptional and transcriptional regulation. In Drosophila, piRNAs are processed within unique non‐membrane structures: nuage in germline cells and Yb bodies in somatic gonadal cells.
Ritsuko Suyama, Toshie Kai
wiley +1 more source
3'-Phosphoadenosine 5'-Phosphate Accumulation Delays the Circadian System. [PDF]
, 2018 The circadian system optimizes cellular responses to stress, but the signaling pathways that convey the metabolic consequences of stress into this molecular timekeeping mechanism remain unclear.
Chan, Kai Xun +2 more
core +3 more sources
Defective Processing of Cytoplasmic and Chloroplast Ribosomal RNA in the Absence of Arabidopsis DXO1
Plant, Cell &Environment, Volume 48, Issue 6, Page 4227-4244, June 2025.ABSTRACT Decapping 5′‐3′ exoribonucleases from the DXO/Rai1 family are highly conserved among eukaryotes and exhibit diverse enzymatic activities depending on the organism. The biochemical and structural properties of the plant DXO1 differ from the yeast and animal counterparts, which is reflected in the in vivo functions of this enzyme.
Monika Zakrzewska‐Placzek +5 more
wiley +1 more source
A DIStinctively novel exoribonuclease that really likes U
The EMBO Journal, 2013 Regulated degradation plays a major role in determining the levels of both non-coding (miRNA) and coding (mRNA) transcripts. Thus, insights into the factors and pathways that influence this process have broad, interdisciplinary implications. New findings by Malecki et al (2013), Lubas et al (2013), and Chang et al (2013) identify the protein Dis3L2 as ...
Imed E Gallouzi, Jeffrey Wilusz
openaire +3 more sources