Results 101 to 110 of about 83,398 (334)

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Association between insulin resistance and the development of cardiovascular disease

Cardiovascular Diabetology, 2018
For many years, cardiovascular disease (CVD) has been the leading cause of death around the world. Often associated with CVD are comorbidities such as obesity, abnormal lipid profiles and insulin resistance.
Valeska Ormazabal, Soumyalekshmi Nair, Omar Elfeky, Claudio Aguayo, Carlos Salomon, Felipe A. Zuñiga   +5 more
doaj   +1 more source

Cardiac Organoid Model Inspired Micro‐Robot Smart Patch to Treat Myocardial Infarction

Advanced Materials, EarlyView.
The heart organoid model exhibits the acidic microenvironment characteristic of myocardial infarction, which emerges as a pivotal force propelling the movement of micro‐robots. These micro‐robots, administered through microneedles, can penetrate deep into the tissue, effectively delivering therapeutic payloads to facilitate heart repair.
Fangfang Wang, Zilu Xu, Feiyang Zheng, Dongcheng Yang, Kaige Xu, Ming Ke, Xiao Zhou, Xiaohan Zhang, Ju Tan, Yong Liu, Yansha Hao, Malcolm Xing, Chuhong Zhu   +12 more
wiley   +1 more source

Progress in exosome associated tumor markers and their detection methods

Molecular Biomedicine, 2020
Exosomes are secreted by cells and are widely present in body fluids. Exosomes contain various molecular constituents of their cells of origin such as proteins, mRNA, miRNAs, DNA, lipid and glycans which are very similar as the content in tumor cells ...
Mengjiao Shen, Kaili Di, Hongzhang He, Yanyan Xia, Hui Xie, Rongrong Huang, Chang Liu, Mo Yang, Siyang Zheng, Nongyue He, Zhiyang Li   +10 more
doaj   +1 more source

The role of exosomes and exosomal microRNA in diabetic cardiomyopathy

Frontiers in Endocrinology
Diabetic cardiomyopathy, a formidable cardiovascular complication linked to diabetes, is witnessing a relentless surge in its incidence. Despite extensive research efforts, the primary pathogenic mechanisms underlying this condition remain elusive. Consequently, a critical research imperative lies in identifying a sensitive and dependable marker for ...
Shiyu Gao, Yue Dong, Chentao Yan, Tianhao Yu, Hongbo Cao   +4 more
openaire   +3 more sources

Photonic Nanomaterials for Wearable Health Solutions

Advanced Materials, EarlyView.
This review discusses the fundamentals and applications of photonic nanomaterials in wearable health technologies. It covers light‐matter interactions, synthesis, and functionalization strategies, device assembly, and sensing capabilities. Applications include skin patches and contact lenses for diagnostics and therapy. Future perspectives emphasize AI‐
Taewoong Park, Jung Woo Leem, Young L. Kim, Chi Hwan Lee   +3 more
wiley   +1 more source

The RNA Exosome Channeling and Direct Access Conformations Have Distinct In Vivo Functions

Cell Reports, 2016
The RNA exosome is a 3′–5′ ribonuclease complex that is composed of nine core subunits and an essential catalytic subunit, Rrp44. Two distinct conformations of Rrp44 were revealed in previous structural studies, suggesting that Rrp44 may change its ...
Jaeil Han, Ambro van Hoof
doaj   +1 more source

Materials Advances in Devices for Heart Disease Interventions

Advanced Materials, EarlyView.
This review examines the crucial role of materials in heart disease interventions, focusing on strategies for monitoring, managing, and repairing heart conditions. It discusses the material requirements for medical devices, highlighting recent innovations and their impact on cardiovascular health.
Gagan K. Jalandhra, Lauryn Srethbhakdi, James Davies, Chi Cong Nguyen, Phuoc Thien Phan, Zachary Och, Aditya Ashok, Khoon S. Lim, Hoang‐Phuong Phan, Thanh Nho Do, Nigel H. Lovell, Jelena Rnjak‐Kovacina   +11 more
wiley   +1 more source

DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications

Advanced Materials, EarlyView.
DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding, Bing Liu, Andreas Peil, Sisi Fan, Jie Chao, Na Liu   +5 more
wiley   +1 more source

Progress and Application of Multifunctional Hydrogel in Radioactive Skin Injury

Advanced Materials Interfaces, EarlyView.
This review examines healing challenges in radiation‐wound injuries, where ionizing radiation impairs immune and tissue repair processes. Hydrogels, with their biocompatibility, antimicrobial properties, and drug delivery capabilities, present a transformative solution. It compares hydrogel efficacy in radiation‐induced versus common wounds, highlights
Xinyue Cui, Jingyi Wang, Xinyi Xu, Xiqian Cao, Yingtang Zhou, Jiaming Guo   +5 more
wiley   +1 more source