Results 81 to 90 of about 97,593 (306)
, 2015 a) Metabolic labeling of newly synthesized proteins and glycans for exosome composition modulation; b) Bioorthogonal click conjugation for exosome functionalization; c) Streptavidin-HRP conjugation to biotinylated exosome; d) Biotin-FITC encapsulation to
Ming Wang (172316) +3 more
core +1 more source
Advanced Science, EarlyView.Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu +13 more
wiley +1 more source
, 2018 Serum and plasma-derived exosomes were isolated using the precipitation-based reagents TEI and ExoQ; and the column-based method ExoS. Pooled exosomes were characterized at different levels and using different methodologies.
Tânia Soares Martins (5368340) +4 more
core +1 more source
Advanced Science, EarlyView.The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang +11 more
wiley +1 more source
Circulation Research, 2015 Nature has designed clever ways for information and material transfer between cells and for intercellular coordination. Mechanisms include direct cell contact, gap junctions, and receptor-ligand signaling. In the past decade, a particular form of exchange has gained increasing attention, and that is intercellular transfer of extracellular vesicles ...
Yin, Tintut, Linda L, Demer
openaire +2 more sources
, 2018 Crevicular fluid miRNAs in all subjects are predominantly in exosomes; however, some miRNAs are present in exosome-depleted supernatant (A). The higher CT cycles are detected in exosome-depleted supernatant than in exosome pellet after normalized with ...
Yinghua Chen (3703351) +5 more
core +1 more source
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
Journal of Extracellular VesiclesEpidermal permeability barrier defects are associated with several skin diseases, including atopic dermatitis (AD). Using an AD mouse model, we previously demonstrated that topically administered small extracellular vesicles (sEVs) (prepared following ...
Kyong‐Oh Shin +15 more
doaj +1 more source
BMC Musculoskeletal Disorders, 2021 Background Heterotopic ossification (HO) can limit joint activity, causes ankylosis and impairs the function and rehabilitation of patients. Endothelial to mesenchymal transition (EndMT) plays an important role in the pathogenesis of HO, and high ...
Zhenyuan Wei +5 more
doaj +1 more source
The Biogenesis and Functions of Exosomes [PDF]
Traffic, 2002 Exosomes are membrane vesicles with a diameter of 40–100 nm that are secreted by many cell types into the extracellular milieu. They correspond to the internal vesicles of an endosomal compartment, the multivesicular body and are released upon exocytic fusion of this organelle with the plasma membrane. Intracellularly, they are formed by inward budding
Stoorvogel, Willem +3 more
openaire +3 more sources