Results 71 to 80 of about 94,365 (207)

Association between insulin resistance and the development of cardiovascular disease

Cardiovascular Diabetology, 2018
For many years, cardiovascular disease (CVD) has been the leading cause of death around the world. Often associated with CVD are comorbidities such as obesity, abnormal lipid profiles and insulin resistance.
Valeska Ormazabal, Soumyalekshmi Nair, Omar Elfeky, Claudio Aguayo, Carlos Salomon, Felipe A. Zuñiga   +5 more
doaj   +1 more source

Exosome-like Nanovesicles Derived from the Mucilage of Pinctada Martensii Exhibit Antitumor Activity against 143B Osteosarcoma Cells

, 2023
Osteosarcoma is prone to metastasis and has a low long-term survival rate. The drug treatment of osteosarcoma, side effects of treatment drugs, and prognosis of patients with lung metastasis continue to present significant challenges, and the efficacy of
Zijie Wu (8920853), Chengyong Li (1422349), Linhong Yan (15905788), Hao Lin (123504), Mingzhu Deng (11000570), Zifan Lu (4927915), Peng Li (69518), Guanhao Hong (15905782), Weiqiang Zhan (173880), Lihua Ma (308526), Dong Xie (16842), Peichun Lin (15905785)   +11 more
core   +1 more source

Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism [PDF]

, 2010
For a long time it has been assumed that the decay of RNA in eukaryotes is mainly carried out by exoribonucleases, which is in contrast to bacteria, where endoribonucleases are well documented to initiate RNA degradation.
Tomecki, Rafał, Dziembowski, Andrzej
core   +3 more sources

Exosome-like Nanozyme Vesicles for H₂O₂‑Responsive Catalytic Photoacoustic Imaging of Xenograft Nasopharyngeal Carcinoma

, 2018
Photoacoustic imaging (PAI) is an attractive imaging modality, which is promising for clinical cancer diagnosis due to its advantages on deep tissue penetration and fine spatial resolution.
Beiping Miao (6083846), Lizeng Gao, Aifa Tang (151044), Aifa Tang, Minmin Liang (2069377), Ni Xie (606366), Yang Liu (4829), Guohui Nie, Yang Liu, Hanwei Wu (6083849), Xiyun Yan (101871), Minmin Liang, Kelong Fan, Hui Ding (308976), Hanwei Wu, Yanjuan Cai (6083843), Beiping Miao, Kelong Fan (2069374), Guohui Nie (5082191), Yanjuan Cai, Ni Xie, Lizeng Gao (406268), Hui Ding, Xiyun Yan   +23 more
core   +1 more source

Small EVs From Adipose‐Derived MSCs Modulate Epidermal Barrier and Inflammation Via Sphingosine‐1‐Phosphate Signaling Pathway

Journal of Extracellular Vesicles
Epidermal permeability barrier defects are associated with several skin diseases, including atopic dermatitis (AD). Using an AD mouse model, we previously demonstrated that topically administered small extracellular vesicles (sEVs) (prepared following ...
Kyong‐Oh Shin, Jun Ho Lee, Seungwoo Chae, Karin Goto, Hahyun An, Joan S. Wakefield, Dae Hyun Ha, Healim Lee, Kyojin Lee, Hyunju Lee, Ella Shin, Min Ji Kang, Sinhee Lee, Yoshikazu Uchida, Byong Seung Cho, Kyungho Park   +15 more
doaj   +1 more source

Exosomes for gene therapy effectively inhibit the endothelial-mesenchymal transition in mouse aortic endothelial cells

BMC Musculoskeletal Disorders, 2021
Background Heterotopic ossification (HO) can limit joint activity, causes ankylosis and impairs the function and rehabilitation of patients. Endothelial to mesenchymal transition (EndMT) plays an important role in the pathogenesis of HO, and high ...
Zhenyuan Wei, Yang Zhao, Peichun Hsu, Shang Guo, Chi Zhang, Biao Zhong   +5 more
doaj   +1 more source

Therapeutic potential of mesenchymal stem cell‐derived extracellular vesicles in SARS‐CoV‐2 and H1N1 influenza‐induced acute lung injury

Journal of Extracellular Vesicles
Mesenchymal stem cell (MSC)‐derived extracellular vesicles (EVs) have shown anti‐inflammatory potential in multiple inflammatory diseases. In the March 2022 issue of the Journal of Extracellular Vesicles, it was shown that EVs from human MSCs can ...
Jun Ho Lee, Hyungtaek Jeon, Jan Lötvall, Byong Seung Cho   +3 more
doaj   +1 more source

Exosomes [PDF]

Circulation Research, 2015
Nature has designed clever ways for information and material transfer between cells and for intercellular coordination. Mechanisms include direct cell contact, gap junctions, and receptor-ligand signaling. In the past decade, a particular form of exchange has gained increasing attention, and that is intercellular transfer of extracellular vesicles ...
Yin, Tintut, Linda L, Demer
openaire   +2 more sources

Extracellular vesicle delivery of Myricetin suppresses ovarian cancer through mitochondrial dynamics by downregulating the ECM1/NF-κB/TGFβ signaling pathway

Scientific Reports
Ovarian cancer is classified as a female malignancy commonly known as a silent killer with no early detection symptoms. Extracellular matrix protein 1 (ECM1) is associated with the Epithelial-mesenchymal transition (EMT) and metastasis process in ...
Kaumudi Pande, Sridevi Annapurna Singh, Anbarasu Kannan   +2 more
doaj   +1 more source

Cutting edge: Regulation of exosome secretion by the integral MAL protein in T cells [PDF]

, 2015
Exosomes secreted by T cells play an important role in coordinating the immune response. HIV-1 Nef hijacks the route of exosome secretion of T cells to modulate the functioning of uninfected cells.
Fernández Martín, Laura, Fernández-Martín, Laura, Martínez-Alonso, Emma, Alonso, Miguel A., Antón Hurtado, Olga María, Martínez-Menárguez, José Angel, Andrés, Germán, Martínez-Menárguez, José A., Antón, Olga M., Ventimiglia, Leandro, Guerra, Milagros, Alonso, Miguel   +11 more
core   +1 more source