A Quantitative Pharmacology Model of Exosome-Mediated Drug Efflux and Perturbation-Induced Synergy
Pharmaceutics, 2021 Exosomes, naturally occurring vesicles secreted by cells, are undergoing development as drug carriers. We used experimental and computational studies to investigate the kinetics of intracellular exosome processing and exosome-mediated drug efflux and the
Jin Wang +8 more
doaj +1 more source
Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes [PDF]
, 2013 Introduction: In recent years, there has been an exponential increase in the number of studies aiming to understand the biology of exosomes, as well as other extracellular vesicles.
Szabó, Tamas G +21 more
core +1 more source
Cholesterol Regulates Exosome Release in Cultured Astrocytes
Frontiers in Immunology, 2021 Exosomes are vesicles secreted by various kinds of cells, and they are rich in cholesterol, sphingomyelin (SM), phosphatidylcholine, and phosphatidylserine.
Mohammad Abdullah +6 more
doaj +1 more source
Defined MSC exosome with high yield and purity to improve regenerative activity
Journal of Tissue Engineering, 2021 Exosomes derived from mesenchymal stem cells (MSCs) have been studied as vital components of regenerative medicine. Typically, various isolation methods of exosomes from cell culture medium have been developed to increase the isolation yield of exosomes.
Jun Yong Kim +7 more
doaj +1 more source
Modeling exosome complexes from cross-link MS data
, 2015 <p>This repository contains the modeling scripts, the ensemble of models, and the results of the analysis for the modeling of the <em>S.cerevisiae</em> exosome complex (named exo10, comprising of Rrp40, Rrp4, Csl4, Rrp45, Rrp46, Rrp42 ...
Shi, Yi +19 more
core +2 more sources
Identification of Immunoreactive Tumour Antigens Using Free and Exosome-Associated Humoral Responses
Journal of Circulating Biomarkers, 2013 Altered tumour antigens can initiate cellular and humoral immune responses; however, they often fail to eliminate tumours. In humans, the presence of cancer is generally associated with the suppression of T cell activation and effector responses ...
Carolyn D. Roberson +4 more
doaj +1 more source
Single-Exosome-Counting Immunoassays for Cancer Diagnostics
, 2018 Exosomes shed by tumor cells have been recognized as promising biomarkers for cancer diagnostics due to their unique composition and functions. Quantification of low concentrations of specific exosomes present in very small volumes of clinical samples ...
Xiaonan Xu (844921) +8 more
core +1 more source
Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation [PDF]
, 2007 A family of HEAT-repeat containing ribosome synthesis factors was previously identified in Saccharomyces cerevisiae. We report the detailed characterization of two of these factors, Utp10 and Utp20, which were initially identified as components of the ...
Tollervey, David +2 more
core +1 more source
Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus
Journal of Translational Medicine, 2021 Background Gestational diabetes mellitus (GDM) is a serious public health issue affecting 9–15% of all pregnancies worldwide. Recently, it has been suggested that extracellular vesicles (EVs) play a role throughout gestation, including mediating a ...
Soumyalekshmi Nair +18 more
doaj +1 more source
The Biogenesis and Functions of Exosomes [PDF]
Traffic, 2002 Exosomes are membrane vesicles with a diameter of 40–100 nm that are secreted by many cell types into the extracellular milieu. They correspond to the internal vesicles of an endosomal compartment, the multivesicular body and are released upon exocytic fusion of this organelle with the plasma membrane. Intracellularly, they are formed by inward budding
Stoorvogel, Willem +3 more
openaire +3 more sources