Results 91 to 100 of about 158,436 (362)

Exosomes and Cardiovascular Protection [PDF]

Cardiovascular Drugs and Therapy, 2016
Most, if not all, cells of the cardiovascular system secrete small, lipid bilayer vesicles called exosomes. Despite technical challenges in their purification and analysis, exosomes from various sources have been shown to be powerfully cardioprotective.
Davidson, SM, Takov, K, Yellon, DM
openaire   +4 more sources

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

The Role of CDR1as in Proliferation and Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells

Stem Cells International, 2019
Mesenchymal stem cells derived from human umbilical cord (hucMSCs) are considered a promising tool for regenerative medicine. circRNAs as newly discovered noncoding RNAs are involved in multiple biological processes.
Lunyu Yang, Zhang Bin, Shi Hui, Li Rong, Benshuai You, Peipei Wu, Xinye Han, Hui Qian, Wenrong Xu   +8 more
doaj   +1 more source

High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources [PDF]

Journal of Extracellular Vesicles, 2016
Extracellular vesicles (EVs), including exosomes and microvesicles (MVs), are explored for use in diagnostics, therapeutics and drug delivery. However, little is known about the relationship of protein and lipid composition of EVs and their source cells.
Reka A. Haraszti, Marie-Cecile Didiot, Ellen Sapp, John Leszyk, Scott A. Shaffer, Hannah E. Rockwell, Fei Gao, Niven R. Narain, Marian DiFiglia, Michael A. Kiebish, Neil Aronin, Anastasia Khvorova   +11 more
doaj   +1 more source

Initial characterisation of exosomes released by umbilical cord-derived mesenchymal stem cells and mature dendritic cells, under ‘Good Manufacturing Practice’ conditions

Vietnam Journal of Science, Technology and Engineering, 2022
Exosomes represent an important mode of intercellular communication and play key roles in many physiological and pathological processes. Exosomes have hitherto exhibited their capacity to modulate biological activities through their carrying of ...
Hoang Huong Diem, Bui Thi Van Khanh, Hoang Thi My Nhung, Nguyen Thanh Liem, Than Thi Trang Uyen   +4 more
doaj   +1 more source

Size stability and self-agglomeration of erythrocyte-derived membrane nanovesicles versus physiological extracellular vesicles [PDF]

arXiv, 2023
Extracellular vesicles (EVs) and plasma membrane-derived exosome-mimetic nanovesicles demonstrate significant potential for drug delivery. Latter synthetic provides higher throughput over physiological EVs. However they face size-stability and self-agglomeration challenges in physiological solutions to be properly characterized and addressed.
arxiv  

Exosomes in developmental signalling [PDF]

Development, 2016
In order to achieve coordinated growth and patterning during development, cells must communicate with one another, sending and receiving signals that regulate their activities. Such developmental signals can be soluble, bound to the extracellular matrix, or tethered to the surface of adjacent cells.
Ian John McGough, Jean-Paul Vincent
openaire   +4 more sources

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients. [PDF]

PLoS ONE, 2009
BACKGROUND: Metastatic melanoma is an untreatable cancer lacking reliable and non-invasive markers of disease progression. Exosomes are small vesicles secreted by normal as well as tumor cells.
Mariantonia Logozzi, Angelo De Milito, Luana Lugini, Martina Borghi, Luana Calabrò, Massimo Spada, Maurizio Perdicchio, Maria Lucia Marino, Cristina Federici, Elisabetta Iessi, Daria Brambilla, Giulietta Venturi, Francesco Lozupone, Mario Santinami, Veronica Huber, Michele Maio, Licia Rivoltini, Stefano Fais   +17 more
doaj   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source