Results 111 to 120 of about 177,584 (349)

Silencing Myostatin Using In Vivo Self‐Assembled siRNA Protects Against Cancer‐ and Dexamethasone‐Induced Muscle Atrophy

Advanced Healthcare Materials, EarlyView.
This study reports an in vivo self‐assembled siRNA strategy that enables the liver to generate small extracellular vesicles (sEVs) tagged with a muscle‐targeting peptide (MSP) and naturally loaded with myostatin (MSTN)‐siRNA. These MSP‐tagged sEVs are systemically delivered to skeletal muscle, efficiently silence MSTN, promote muscle hypertrophy, and ...
Xin Yin, Azhar Anwar, Jiehao Chen, Qinghao Sun, Likun Zhou, Jie Tang, Jingwei Guo, Linbo Yan, Yongci Chen, Feng Yin, Chen‐Yu Zhang, Zigang Li, Jizheng Ma, Liyuan Sheng, Xi Chen   +14 more
wiley   +1 more source

Lipidomics and biodistribution of extracellular vesicles‐secreted by hepatocytes from Zucker lean and fatty rats

Journal of Extracellular Biology
Extracellular vesicles (EVs) have been involved in metabolic syndrome, although their specific role in the development of the pathology is still unknown.
Maria Azparren‐Angulo, Justyna Mleczko, Oihane E. Alboniga, Sergei Kruglik, Jean‐Michel Guigner, Esperanza Gonzalez, Clara Garcia‐Vallicrosa, Jordi Llop, Cristina Simó, Cristina Alonso, Marta Iruarrizaga, Felix Royo, Juan M. Falcon‐Perez   +12 more
doaj   +1 more source

The miRNA-21-5p Payload in Exosomes from M2 Macrophages Drives Tumor Cell Aggression via PTEN/Akt Signaling in Renal Cell Carcinoma [PDF]

, 2022
Zhicheng Zhang, Junhui Hu, Moe Ishihara, Allison C. Sharrow, Kailey Flora, Yao He, Lily Wu   +6 more
openalex   +1 more source

The significance of exosomes in the development and treatment of hepatocellular carcinoma

Molecular Cancer, 2020
Hepatocellular carcinoma (HCC) is the most commonmalignancy. Exsome plays a significant role in the elucidation of signal transduction pathways between hepatoma cells, angiogenesis and early diagnosis of HCC.
Xin Li, Chuanyun Li, Liping Zhang, Min Wu, K. Cao, Fei-long Jiang, Dexi Chen, Ning Li, Weihua Li   +8 more
semanticscholar   +1 more source

A Sacrificial 3D Printed Vessel‐on‐Chip Demonstrates a Versatile Approach to Model Granulation Tissue

Advanced Healthcare Materials, EarlyView.
A novel method that combines 3D printing and organ‐on‐chip technology enables the creation of hollow channels lined with endothelial cells through a fibroblast‐populated connective tissue matrix. The model supports stable metabolic culture conditions, angiogenic sprouting, and immune cell migration, thereby demonstrating an easy and versatile method to
Jonas Jäger, Phil Berger, Andrew I. Morrison, Hendrik Erfurth, Maria Thon, Eva‐Maria Dehne, Susan Gibbs, Jasper J. Koning   +7 more
wiley   +1 more source

M2 macrophage-derived exosomes suppress tumor intrinsic immunogenicity to confer immunotherapy resistance [PDF]

, 2023
Naisheng Zheng, Tingting Wang, Qin Luo, Yi Liu, Junyao Yang, Yunlan Zhou, Guohua Xie, Yanhui Ma, Xiangliang Yuan, Lisong Shen   +9 more
openalex   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages

Journal of Translational Medicine, 2011
Background Exosomes are 30-100 nm membrane vesicles of endocytic origin produced by numerous cells. They can mediate diverse biological functions, including antigen presentation.
Gabrielsson Susanne, Sjöstrand Margareta, Bossios Apostolos, Torregrosa Paredes Patricia, Eldh Maria, Ekström Karin, Seyed Alikhani Vesta, Lässer Cecilia, Lötvall Jan, Valadi Hadi   +9 more
doaj   +1 more source

Smart Catheters for Diagnosis, Monitoring, and Therapy

Advanced Healthcare Materials, EarlyView.
This study presents a comprehensive review of smart catheters, an emerging class of medical devices that integrate embedded sensors, robotics, and communication systems, offering increased functionality and complexity to enable real‐time health monitoring, diagnostics, and treatment. Abstract This review explores smart catheters as an emerging class of
Azra Yaprak Tarman, Samiha Ahmed, Majed Othman Althumayri, Megan Guy, Darlenne Chavez Lugo, Frances S. Ligler, George T. Ligler, Rahmi Oklu, Hiroshi Kawahira, Michael J. McShane, Jun Kameoka, Jonathan Bova, Hatice Ceylan Koydemir   +12 more
wiley   +1 more source

P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice [PDF]

, 2020
Zhi Ruan, Jean-Christophe Delpech, Srinidhi Venkatesan Kalavai, Alicia A. Van Enoo, Jianqiao Hu, Seiko Ikezu, Tsuneya Ikezu   +6 more
openalex   +1 more source