Results 101 to 110 of about 19,438 (226)

Humanized CD7 nanobody-based immunotoxins exhibit promising anti-T-cell acute lymphoblastic leukemia potential

International Journal of Nanomedicine, 2017
Yuan Yu,1–3 Jialu Li,1–3 Xuejun Zhu,4 Xiaowen Tang,2,5 Yangyi Bao,6 Xiang Sun,6 Yuhui Huang,1,2 Fang Tian,4 Xiaomei Liu,1,2 Lin Yang1–3 1The Cyrus Tang Hematology Center, 2Collaborative Innovation Center of Hematology, Soochow ...
Yu Y, Li J, Zhu X, Tang X, Bao Y, Sun X, Huang Y, Tian F, Liu X, Yang L   +9 more
doaj  

Beta‐Thalassemia Major Complicated by Streptococcal Toxic Shock Syndrome: A Rare Case of Survival and Successful Management

Case Reports in Hematology, Volume 2026, Issue 1, 2026.
Beta‐thalassemia is an inherited blood disorder associated with defective hemoglobin production and impaired immunity, increasing susceptibility to severe infections. Streptococcus pyogenes poses a significant risk due to its potential to cause streptococcal toxic shock syndrome (STSS), a life‐threatening condition characterized by fever, shock, and ...
Fajr Saeedi, Masaheer A. Aljehani, Suraiya Saleem   +2 more
wiley   +1 more source

Abrin Toxin Paradoxically Increases Protein Synthesis in Stimulated CD4⁺ T-Cells While Decreasing Protein Synthesis in Kidney Cells

Current Issues in Molecular Biology
Abrin, a toxin of the rosary pea plant (Abras precatorius), has been implicated as causing an autoimmune demyelinating disease in humans, but the exact mechanisms responsible for the induction of these demyelinating conditions are still unknown.
Bradley Hernlem, Reuven Rasooly
doaj   +1 more source

Detection of Exotoxins and Antimicrobial Susceptibility Pattern in Clinical Pseudomonas Aeruginosa Isolates [PDF]

, 2017
Background: Pseudomonas aeruginosa is a common opportunistic pathogen that causes nosocomial infection in immunocompromised patients. Among different virulence factors, the type III secretion system (TTSS) is an important agent in virulence and ...
Deris, Fatemeh., Gholipour, Abolfazl., Malek Mohamad, Somayeh., Rostami, Soodabeh., Zamanzad, Behnam.   +4 more
core   +1 more source

Superantigenic Staphylococcal Exotoxins Induce T-Cell Proliferation in the Presence of Langerhans Cells or Class II–Bearing Keratinocytes and Stimulate Keratinocytes to Produce T-Cell–Activating Cytokines

Journal of Investigative Dermatology, 1994
Several staphylococcal toxins are among a growing number of immunostimulatory molecules called "superantigens" because of their ability, when presented by appropriate major histocompatibility complex class II+ accessory cells, to activate essentially all T cells bearing particular T-cell receptor V beta gene segments.
Tokura, Yoshiki, Yagi, Junji, Mark O'Malley, Junji, Lewis, Julia M., Takigawa, Masahiro, Edelson, Richard L., Tigelaar, Robert E.   +6 more
openaire   +2 more sources

Paradoxical effect of pertussis toxin on the delayed hypersensitivity response to autoantigens in mice.

PLoS ONE, 2010
BackgroundPertussis toxin (PTX), an exotoxin of Bordetella pertussis, enhances the development of experimental autoimmune diseases such as experimental autoimmune uveitis (EAU) and experimental autoimmune encephalomyelitis (EAE) in rodent models.
Rajwahrdhan Yadav, Sourojit Bhowmick, Philip Gorecki, James O'Rourke, Robert E Cone   +4 more
doaj   +1 more source

Sepsis caused by bloodstream infection in patients in the intensive care unit: the impact of inactive empiric antimicrobial therapy on outcome [PDF]

, 2018
Background: Sepsis is one of the leading causes of death in the UK. Aims: The aims of this study were to identify the rate of inactive antimicrobial therapy (AMT) in the ICU and whether inactive AMT had an effect on in hospital mortality, ICU ...
Booth, M.G., Brooks, Daniel, Polubothu, Padmaja, Smith, A., Young, D.   +4 more
core   +1 more source

Cooperative research and development opportunities with the National Cancer Institute [PDF]

The Office of Technology Development (OTD) of the National Cancer Institute (NCI) is responsible for negotiating Cooperative Research and Development Agreements (CRADAs), whereby the knowledge resulting from NCI investigators' government-sponsored ...
Sybert, Kathleen
core   +1 more source

Early detection of – comparison of conventional versus molecular (PCR) detection directly from adult patients with cystic fibrosis (CF) [PDF]

, 2004
Background Pseudomonas aeruginosa (PA) is the most important bacterial pathogen in patients with cystic fibrosis (CF) patients. Currently, routine bacteriological culture on selective/non- selective culture media is the cornerstone of microbiological ...
Jiru Xu, John E Moore, Philip G Murphy, B Cherie Millar, J Stuart Elborn   +4 more
core   +2 more sources

A lipid nanoparticle encapsulated CPA-CTD mRNA vaccine provides protection against Clostridium perfringens-driven diseases

Frontiers in Immunology
IntroductionClostridium perfringens (C. perfringens), a ubiquitous Gram-positive bacterium in the environment and mammalian gut flora, is a leading cause of enterotoxemia in animals, necrotizing enteritis in humans and animals, and gas gangrene in both ...
Qi Jia, Haoyu Xiang, Haoyu Xiang, Ting Le, Jing Wang, Jing Wang, Jitao Chang, Fang Wang, Chao Sun, Wanbo Tai, Zhigang Jiang, Xin Yin, Xin Yin   +12 more
doaj   +1 more source