Results 131 to 140 of about 11,626 (172)
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Selective activation of murine Vβ8.2 bearing T cells by Pseudomonas exotoxin A
Cellular Immunology, 1992We have determined that Pseudomonas aeruginosa exotoxin A (PE) can selectively stimulate the proliferation of V beta bearing T lymphocytes. Murine thymocytes were fractionated by selective agglutination with peanut agglutinin (PNA) and the PNA- thymocytes, which represent mature thymocytes, were shown to be responsive to PE stimulation.
D M, Dixon, R D, LeGrand, M L, Misfeldt
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Proliferation of Immature T Cells within the Splenocytes of Athymic Mice by Pseudomonas Exotoxin A
Cellular Immunology, 1994Pseudomonas aeruginosa exotoxin A has been shown to stimulate splenocytes from athymic nude mice. The present studies were performed to characterize the exotoxin A-responsive cells within the splenocytes of athymic nude mice. The results of these studies indicate that exotoxin A-responsive cells were represented in the nylon wool-adherent cell ...
D M, Dixon, M L, Misfeldt
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Acute Hepatotoxicity of Pseudomonas aeruginosa Exotoxin A in Mice Depends on T Cells and TNF
The Journal of Immunology, 1998Abstract The most potent virulence factor of Pseudomonas aeruginosa, its exotoxin A (PEA), inhibits protein synthesis, especially in the liver, and is a weak T cell mitogen. This study was performed to correlate hepatotoxic and possible immunostimulatory features of PEA in vivo.
J, Schümann +4 more
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Modulation of Suppressor T-Cells by Streptococcal Pyrogenic Exotoxin
1981The V-region gene repertoire which determines the qualitative nature of an organisms’ antibody response is encoded in the genome of the immunoglobulin forming cells (B-lymphocytes) of the organism. Other cells such as thymus derived lymphocytes (T-cells) and macrophages appear to regulate or control the antibody responses of B- lymphocytes to many ...
Edgar E. Hanna +2 more
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A conserved mechanism of T lymphocyte stimulation by microbial exotoxins
Microbial Pathogenesis, 1989Les enterotoxines de Staphylococcus aureus (SE) ont une activite mitogene sur les lymphocytes T. Cette stimulation des cellules T est dependante de la presence de monocytes comme cellules accessoires (AC). La liaison de SE a un antigene d'histocompatibilite de classe II meme xenogenique est suffisante pour obtenir la stimulation.
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Cellular Immunology, 1991
We have examined the functions required of accessory cells (AC) for murine thymocyte proliferation induced by Pseudomonas exotoxin A (PE) and have compared these functions to those required of a known superantigen, staphylococcal enterotoxin B (SEB).
P K, Legaard +2 more
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We have examined the functions required of accessory cells (AC) for murine thymocyte proliferation induced by Pseudomonas exotoxin A (PE) and have compared these functions to those required of a known superantigen, staphylococcal enterotoxin B (SEB).
P K, Legaard +2 more
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Cellular Immunology, 1995
Previous studies have demonstrated that Pseudomonas exotoxin A stimulated the proliferation of immature T lymphocytes within the splenocytes of athymic mice. These studies were performed to determine which lymphokines were involved in the proliferation of the immature T cells.
D M, Dixon, M L, Misfeldt
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Previous studies have demonstrated that Pseudomonas exotoxin A stimulated the proliferation of immature T lymphocytes within the splenocytes of athymic mice. These studies were performed to determine which lymphokines were involved in the proliferation of the immature T cells.
D M, Dixon, M L, Misfeldt
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The Human T Cell Response to Mitogenic Microbial Exotoxins
1991Nearly every infectious pathogen has to cope with the host’s adaptive immune response. Common evasion mechanisms in this complex interaction are antigenic variations, the escape to immunologically privileged sites, or the use of immunosuppressive mechanisms.
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Immunopharmacology and Immunotoxicology, 2005
Proinflammatory cytokines mediate the toxic effects of superantigenic staphylococcal exotoxins (SE) and bacterial lipopolysaccharide (LPS). Triptolide, an oxygenated diterpene derived from a traditional Chinese medicinal herb, Tripterygium wilfordii, inhibited SE-stimulated T-cell proliferation (by 98%) and expression of interleukin 1beta, interleukin ...
Teresa, Krakauer +3 more
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Proinflammatory cytokines mediate the toxic effects of superantigenic staphylococcal exotoxins (SE) and bacterial lipopolysaccharide (LPS). Triptolide, an oxygenated diterpene derived from a traditional Chinese medicinal herb, Tripterygium wilfordii, inhibited SE-stimulated T-cell proliferation (by 98%) and expression of interleukin 1beta, interleukin ...
Teresa, Krakauer +3 more
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Clinical & Experimental Allergy, 2009
SummaryBackground The pathogenesis of nasal polyps is still unclear. There is increasing evidence indicating that Staphylococcal aureus (S. aureus) is associated with the formation of nasal polyps, but the mechanism has not been well documented to date.Methods We stimulated cultured nasal polyps and turbinate tissues with Staphylococcal ...
G, Xu +7 more
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SummaryBackground The pathogenesis of nasal polyps is still unclear. There is increasing evidence indicating that Staphylococcal aureus (S. aureus) is associated with the formation of nasal polyps, but the mechanism has not been well documented to date.Methods We stimulated cultured nasal polyps and turbinate tissues with Staphylococcal ...
G, Xu +7 more
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