Results 51 to 60 of about 19,438 (226)

Enhanced nasopharyngeal infection and shedding associated with an epidemic lineage of emm3 group A Streptococcus [PDF]

, 2017
Background: A group A Streptococcus (GAS) lineage of genotype emm3, sequence type 15 (ST15) was associated with a six month upsurge in invasive GAS disease in the UK.
Afshar, B, Al-Shahib, A, Efstratiou, A, Holden, M T G, Lamagni, T L, Smith, K C, Sriskandan, S, Turner, C E, Underwood, A   +8 more
core   +3 more sources

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Molecular Genetic Typing of Staphylococcus aureus from Cows, Goats, Sheep, Rabbits and Chickens [PDF]

, 2006
End of project reportsS. aureus can also cause a number of infections in animals such as tick-associated pyaemia in lambs, staphylococcosis in rabbits, septicaemia, abscesses and chondronecrosis in chickens and pneumonia and osteomyelitis complex in ...
Hartigan, Patrick J., Meaney, William J, Smyth, Cyril James, Smyth, Davida S.   +3 more
core  

Pseudomonas exotoxin-anti-TAC. Cell-specific immunotoxin active against cells expressing the human T cell growth factor receptor. [PDF]

Journal of Clinical Investigation, 1984
An immunotoxin was constructed with an activity that discriminated between two T cell lines based on the expression of the T cell growth factor (TCGF) receptor on their cell surface. A toxic protein conjugate, designated PE-anti-TAC, was made by chemically coupling pseudomonas exotoxin (PE) to a monoclonal antibody (anti-TAC) that recognizes the human ...
D J, FitzGerald, T A, Waldmann, M C, Willingham, I, Pastan   +3 more
openaire   +2 more sources

Cell membrane‐coated nanoparticles for dermatological diseases

VIEW, EarlyView.
Skin disorders are challenging to treat due to complex barrier functions and limited conventional therapies. Biomimetic cell membrane‐coated nanoparticles (CM‐NPs) offer a superior nanomedicine approach by evading immune detection and enabling precise targeting.
Shuaijun Zou, Baojie Zhang, Yuanjie Zhu
wiley   +1 more source

Staphylococcal Superantigens Stimulate Epithelial Cells through CD40 To Produce Chemokines

mBio, 2019
Mucosal and skin tissues form barriers to infection by most bacterial pathogens. Staphylococcus aureus causes diseases across these barriers in part dependent on the proinflammatory properties of superantigens.
Patrick M. Schlievert, Michael P. Cahill, Bruce S. Hostager, Amanda J. Brosnahan, Aloysius J. Klingelhutz, Francoise A. Gourronc, Gail A. Bishop, Donald Y. M. Leung   +7 more
doaj   +1 more source

Characterization and expression analysis of Staphylococcus aureus pathogenicity island 3 - Implications for the evolution of staphylococcal pathogenicity islands [PDF]

, 2002
We describe the complete sequence of the 15.9-kb staphylococcal pathogenicity island 3 encoding staphylococcal enterotoxin serotypes B, K, and Q. The island, which meets the generally accepted definition of pathogenicity islands, contains 24 open reading
Kapur, Vivek, McCormick, John K., Orwin, Paul M., Paustian, Michael L., Schlievert, Patrick M., Yarwood, Jeremy M.   +5 more
core  

Structure of a translocation signal domain mediating conjugative transfer by Type IV secretion systems [PDF]

, 2013
Relaxases are proteins responsible for the transfer of plasmid and chromosomal DNA from one bacterium to another during conjugation. They covalently react with a specific phosphodiester bond within DNA origin of transfer sequences, forming a nucleo ...
Gruber, C.J., Ilangovan, Aravindan, Lang, S., Redzej, Adam, Topf, Maya, Waksman, Gabriel, Zangger, K., Zechner, E.L.   +7 more
core   +1 more source

Spontaneous Clearance of a Secondary Buruli Ulcer Lesion Emerging Ten Months after Completion of Chemotherapy-A Case Report from Togo [PDF]

, 2012
Mycolactone, the macrolide exotoxin produced by Mycobacterium ulcerans, causes extensive tissue destruction by inducing apoptosis of host cells. In this study, we aimed at the production of antibodies that could neutralize the cytotoxic activities of ...
Abiba Banla Kere, Adolf Diefenhardt, Basil Kobara, Dominik Symank, Ebekalisai Piten, Franz Wiedemann, Gisela Bretzel, Harald Hoffmann, Issaka Maman, Jörg Nitschke, Komi Amekuse, Kossi Badziklou, Marcus Beissner, Moritz Jansson, Richard O. Phillips, Thomas Löscher   +15 more
core   +5 more sources

Localized Periodontitis in Young Individuals: Aggregatibacter JP2 Clone, Immunological Dysfunctions and Other Stories

Journal of Periodontal Research, EarlyView.
This review describes the features of grade C molar‐incisor pattern periodontitis and discusses the role of A. actinomycetemcomitans in its pathogenesis and why molars and incisors are preferably affected. Possible future studies on this aggressive disease in primary and permanent dentition and emerging omics techniques for diagnosis and management are
Luigi Nibali, Meaad M. Alamri, Manuela Maria Viana Miguel, Luciana Shaddox   +3 more
wiley   +1 more source