Results 31 to 40 of about 11,626 (172)
Activation of murine T-suppressor lymphocytes by group A streptococcal and staphylococcal pyurogenic exotoxins [PDF]
Infection and Immunity, 1980 The effect of group A streptococcal pyrogenic exotoxin (PE) type C and staphylococcal PE on the in vitro antibody response to sheep erythrocytes was studied in cultures of mouse spleen cells. Both exotoxins suppressed the day 4 direct plaque-forming cell response when added to the cultures.
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The Immunomodulatory Effect of Recombinant Exotoxin A of Pseudomonas Aeruginosa on Dendritic Cells Extracted from Mice Spleen [PDF]
Journal of Advanced Biomedical Sciences, 2014 Background & Objective: Dendritic cell (DC) is as a key cell in activation of immune response against microbes and disease. Therefore, the effect of recombinant exotoxin A of Pseudomonas aeruginosa on the maturity and the activation of DCs was evaluated ...
Mohammad Hossein Karimi +3 more
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T cell activation or tolerization: the Yin and Yang of bacterial superantigens
Frontiers in Microbiology, 2015 Bacterial superantigens are exotoxins from pathogens which interact with innate and adaptive immune cells. The paradox that superantigens cause activation and inactivation/anergy of T-cells was soon recognized.
Aline eSähr +3 more
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Puerperal Fever and Neonatal Pleural Empyema and Bacteremia Caused by Group A Streptococcus
Canadian Journal of Infectious Diseases, 1998 A term neonate developed early onset of sepsis and pleural empyema with group A streptococcus. Her mother also became septic with group A streptococcus in the early postpartum period. The infant required initial chest tube drainage.
Laurance Lequier, Wendy L Vaudry
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Frontiers in Immunology, 2021 Staphylococcus aureus is a leading cause of significant morbidity and mortality and an enormous economic burden to public health worldwide. Infections caused by methicillin-resistant S.
Arundhathi Venkatasubramaniam +13 more
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Distinct T-cell receptor V beta gene usage by human T lymphocytes stimulated with the streptococcal pyrogenic exotoxins and pep M5 protein [PDF]
Infection and Immunity, 1992 A number of streptococcal products, including the streptococcal pyrogenic exotoxin (SPE) types A, B, and C as well as a 22-kDa fragment of M type 5 protein (pep M5), are potent stimulants of human T-lymphocyte blastogenesis and belong to the newly designated family of superantigens.
M A, Tomai, P M, Schlievert, M, Kotb
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Deimmunizing substitutions in Pseudomonas exotoxin domain III perturb antigen processing without eliminating T-cell epitopes [PDF]
Journal of Biological Chemistry, 2019 Effective adaptive immune responses depend on activation of CD4+ T cells via the presentation of antigen peptides in the context of major histocompatibility complex (MHC) class II. The structure of an antigen strongly influences its processing within the endolysosome and potentially controls the identity of peptides that are presented to T cells.
Daniel L. Moss +3 more
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Human Vaccines & Immunotherapeutics, 2020 Staphylococci are the main cause of nosocomial infections globally. The exotoxin staphylococcal enterotoxin B (SEB) produced by methicillin-resistant Staphylococcus aureus is a major cause of pathology after a staphylococcal infection.
Yuanyuan Liu +10 more
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Frontiers in Immunology, 2022 Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a devastating necrotizing skin disease. Key to its pathogenesis is mycolactone, the exotoxin virulence factor that is both immunosuppressive and cytotoxic.
Belinda S. Hall +3 more
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Streptococcal Pyrogenic Exotoxin A-Stimulated Monocytes Mediate Regulatory T-Cell Accumulation through PD-L1 and Kynurenine [PDF]
International Journal of Molecular Sciences, 2019 Bacterial superantigens (SAgs) are exotoxins that promote a fulminant activation of the immune system. The subsequent intense release of inflammatory cytokines often results in hypotension, shock, and organ failure with high mortality rates. In the current paradigm, the direct and simultaneous binding of SAgs with T-cell receptor (TCR)-bearing Vβ ...
Giesbrecht, Katharina +4 more
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