Results 51 to 60 of about 11,626 (172)

IgE‐Binding Bacterial Components Not Yet Documented in the Allergen Databases and Their Allergenic Mechanisms: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Among bacteria that are associated with the development and/or exacerbation of allergic/atopic diseases, several have been described to produce IgE‐binding components. However, only one bacterial protein, Bac s 1, is currently listed in the official database of the World Health Organization/International Union of Immunological Societies (WHO ...
Uta Jappe, Marua Abu Risha, Ioana Agache, Claus Bachert, Barbara Bröker, Riccardo Castagnoli, Gabriele Gadermaier, Richard E. Goodman, Amir Guemari, Christiane Hilger, Alain Jacquet, Sabine Kespohl, Ludger Klimek, Annette Kuehn, Jonas Lidholm, Vera Mahler, Markus Ollert, Thomas A. Platts‐Mills, Monika Raulf, Peter Schmid‐Grendelmeier, Frieder Schmiedeke, Marianne van Hage, Joana Vitte, Josefina Zakzuk, Anna Pomés   +24 more
wiley   +1 more source

In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs)

BMC Genomics, 2005
Background ADP-ribosylation is an enzyme-catalyzed posttranslational protein modification in which mono(ADP-ribosyl)transferases (mARTs) and poly(ADP-ribosyl)transferases (pARTs) transfer the ADP-ribose moiety from NAD onto specific amino acid side ...
Dittmar Katharina, Bazan Fernando, Reche Pedro A, Otto Helge, Haag Friedrich, Koch-Nolte Friedrich   +5 more
doaj   +1 more source

Staphylococcal exotoxins deliver activation signals to human T-cell clones via major histocompatibility complex class II molecules. [PDF]

Proceedings of the National Academy of Sciences, 1991
We investigated whether staphylococcal exotoxins (SEs), in addition to their capacity to induce T-cell activation restricted by the T-cell receptor (TCR) beta-chain variable region, can deliver an activation signal to human T-cell clones through major histocompatibility complex (MHC) class II molecules.
Spertini, F., Spits, H., Geha, R. S.
openaire   +3 more sources

The Mycobacterium tuberculosis phagosome is a HLA-I processing competent organelle. [PDF]

PLoS Pathogens, 2009
Mycobacterium tuberculosis (Mtb) resides in a long-lived phagosomal compartment that resists maturation. The manner by which Mtb antigens are processed and presented on MHC Class I molecules is poorly understood. Using human dendritic cells and IFN-gamma
Jeff E Grotzke, Melanie J Harriff, Anne C Siler, Dawn Nolt, Jacob Delepine, Deborah A Lewinsohn, David M Lewinsohn   +6 more
doaj   +1 more source

Imipenem Resistance Mediated by bla_OXA-913 Gene in Pseudomonas aeruginosa

Antibiotics, 2021
Treatment of infectious diseases caused by carbapenem-resistant Pseudomonas aeruginosa is becoming a greater challenge. This study aimed to identify the imipenem resistance mechanism in P. aeruginosa isolated from a dog. Minimum Inhibitory Concentration (
Dong-Chan Moon, Abraham Fikru Mechesso, Hee-Young Kang, Su-Jeong Kim, Ji-Hyun Choi, Hyun-Ju Song, Soon-Seek Yoon, Suk-Kyung Lim   +7 more
doaj   +1 more source

Streptococcus pyogenes pharyngitis: characterization of strains by multilocus enzyme genotype, M and T protein serotype, and pyrogenic exotoxin gene probing [PDF]

Journal of Clinical Microbiology, 1992
Multilocus enzyme electrophoresis, serological characterization of M and T proteins, and probing for pyrogenic exotoxin A and C genes were used to investigate the bacteriologic epidemiology of strains of Streptococcus pyogenes recovered primarily from patients with recurrent pharyngitis.
J M, Musser, B M, Gray, P M, Schlievert, M E, Pichichero   +3 more
openaire   +2 more sources

Localized Periodontitis in Young Individuals: Aggregatibacter JP2 Clone, Immunological Dysfunctions and Other Stories

Journal of Periodontal Research, EarlyView.
This review describes the features of grade C molar‐incisor pattern periodontitis and discusses the role of A. actinomycetemcomitans in its pathogenesis and why molars and incisors are preferably affected. Possible future studies on this aggressive disease in primary and permanent dentition and emerging omics techniques for diagnosis and management are
Luigi Nibali, Meaad M. Alamri, Manuela Maria Viana Miguel, Luciana Shaddox   +3 more
wiley   +1 more source

Strategies to Improve the Clinical Utility of Saporin-Based Targeted Toxins

Toxins, 2018
Plant Ribosome-inactivating proteins (RIPs) including the type I RIP Saporin have been used for the construction of Immunotoxins (ITxs) obtained via chemical conjugation of the toxic domain to whole antibodies or by generating genetic fusions to antibody
Francesco Giansanti, David J. Flavell, Francesco Angelucci, Maria Serena Fabbrini, Rodolfo Ippoliti   +4 more
doaj   +1 more source

Periodontitis and Diabetes: Mechanistic Evidence of a Circular Relationship

Journal of Periodontal Research, EarlyView.
This narrative review aimed to explore the underlying mechanisms that connect periodontitis to diabetes (and vice versa) and that influence disease susceptibility, progression and response to treatment. ABSTRACT The circular relationship between periodontitis and diabetes mellitus is one of the most established oral‐systemic links.
Philip M. Preshaw, Ren Jie Jacob Chew, Charlene Enhui Goh, Ali A. Abdulkareem, Dana T. Graves   +4 more
wiley   +1 more source

Staphylococcal enterotoxin-like X (SElX) is a unique superantigen with functional features of two major families of staphylococcal virulence factors.

PLoS Pathogens, 2017
Staphylococcus aureus is an opportunistic pathogen that produces many virulence factors. Two major families of which are the staphylococcal superantigens (SAgs) and the Staphylococcal Superantigen-Like (SSL) exoproteins.
Ries J Langley, Yi Tian Ting, Fiona Clow, Paul G Young, Fiona J Radcliff, Jeong Min Choi, Richard P Sequeira, Silva Holtfreter, Heather Baker, John D Fraser   +9 more
doaj   +1 more source