Results 11 to 20 of about 11,626 (172)

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP-ribosylating toxin AB to establish a persistent infection. [PDF]

FEBS Open Bio
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Zabala-Rodriguez MC, Tinker JK, Frisan T, Azarian T, Teter K.   +4 more
europepmc   +2 more sources

Molecular characterization of covRS mutations in M1_UK Streptococcus pyogenes. [PDF]

FEBS Open Bio
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Pritchard J, Proctor EJ, Wang J, Johnston NP, Hayes A, McCorkell G, Yu H, Tree J, Davies MR, Walker MJ, Sluyter R, Brouwer S, Sanderson-Smith ML.   +12 more
europepmc   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer. [PDF]

Mol Oncol
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Kim A, Aslam M, Torruella E, Sony A, Rahman A, Smith S, de la Parra C, Sauane M.   +7 more
europepmc   +2 more sources

Cell and receptor requirements for streptococcal pyrogenic exotoxin T-cell mitogenicity [PDF]

Infection and Immunity, 1991
Streptococcal pyrogenic exotoxins (SPEs) A, B, and C, like other members of the pyrogenic toxin family, are able to cause toxic shock-like syndromes. One of the major properties of these toxins is the ability to induce T-cell proliferation. Characterization of T cell mitogenicity associated with SPEs A, B, and C was undertaken.
B A, Leonard, P K, Lee, M K, Jenkins, P M, Schlievert   +3 more
openaire   +2 more sources

Superantigens in Cancer Immunotherapy: Mechanisms, Engineering Strategies, and Therapeutic Potential. [PDF]

FASEB J
Schematic overview of superantigen‐mediated antitumor immune responses and immune suppression within the tumor microenvironment. (1) Antigen‐presenting cells activate T cells through MHC‐II/TCR interactions resulting in the production of cytokines (2) The pro‐inflammatory cytokines released by activated immune cells stimulate downstream immune ...
Virk UY, Malik HA, Anwer M, Wilson J, Rahi MS, Wei MQ.   +5 more
europepmc   +2 more sources

Periodontal microbiology and microbial etiology of periodontal diseases: Historical concepts and contemporary perspectives

Periodontology 2000, EarlyView., 2023
Abstract This narrative review summarizes the collective knowledge on periodontal microbiology, through a historical timeline that highlights the European contribution in the global field. The etiological concepts on periodontal disease culminate to the ecological plaque hypothesis and its dysbiosis‐centered interpretation.
Georgios N. Belibasakis, Daniel Belstrøm, Sigrun Eick, Ulvi K. Gursoy, Anders Johansson, Eija Könönen   +5 more
wiley   +1 more source

Membrane perturbing properties of toxin mycolactone from Mycobacterium ulcerans. [PDF]

PLoS Computational Biology, 2018
Mycolactone is the exotoxin produced by Mycobacterium ulcerans and is the virulence factor behind the neglected tropical disease Buruli ulcer. The toxin has a broad spectrum of biological effects within the host organism, stemming from its interaction ...
Cesar A López, Clifford J Unkefer, Basil I Swanson, Jessica M J Swanson, S Gnanakaran   +4 more
doaj   +1 more source

The ubiquitin ligase Cbl-b limits Pseudomonas aeruginosa exotoxin T–mediated virulence [PDF]

Journal of Clinical Investigation, 2007
Pseudomonas aeruginosa, an important cause of opportunistic infections in humans, delivers bacterial cytotoxins by type III secretion directly into the host cell cytoplasm, resulting in disruption of host cell signaling and host innate immunity. However, little is known about the fate of the toxins themselves following injection into the host cytosol ...
Priya, Balachandran, Leonard, Dragone, Lynne, Garrity-Ryan, Armando, Lemus, Arthur, Weiss, Joanne, Engel   +5 more
openaire   +2 more sources

DETECTION OF ExoT GENE IN LOCAL ISOLATES OF PSEUDOMONAS AUROGINOSA IN A SAMPLE OF BURN INFECTION

The Iraqi Journal of Medical Sciences, 2018
Background: Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic microorganism that requires damaged mucus membranes and epithelial tissues to cause acute infections. It had been stated that P.
Rana A. Hanoon, Ibtisam G. Auda, Ismail H. Aziz   +2 more
doaj   +6 more sources

Nonspecific T-lymphocyte mitogenesis by pyrogenic exotoxins from group A streptococci and Staphylococcus aureus [PDF]

Infection and Immunity, 1979
Group A streptococcal pyrogenic exotoxins types A, B, and C and staphylococcal pyrogenic exotoxin were shown to be potent nonspecific T-lymphocyte mitogens. Adherent cell populations did not significantly affect the nonspecific mitogenicity.
P M, Schlievert, D J, Schoettle, D W, Watson   +2 more
openaire   +2 more sources