First Description of Mergibacter septicus Isolated from a Common Tern (Sterna hirundo) in Germany
Pathogens, 2023 Mergibacter septicus (M. septicus), previously known as Bisgaard Taxon 40, is a recently described species within the Pasteurellaceae family. In this study, we present a M. septicus strain isolated from a common tern (Sterna hirundo) chick that died just
Mostafa Y. Abdel-Glil +3 more
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Control of established colon cancer xenografts using a novel humanized single chain antibody-streptococcal superantigen fusion protein targeting the 5T4 oncofetal antigen. [PDF]
PLoS ONE, 2014 Superantigens (SAgs) are microbial toxins that cross-link T cell receptors with major histocompatibility class II (MHC-II) molecules leading to the activation of large numbers of T cells.
Kelcey G Patterson +5 more
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Inhibition of toxic shock by human monoclonal antibodies against staphylococcal enterotoxin B. [PDF]
PLoS ONE, 2010 BACKGROUND: Staphylococcus aureus is implicated in many opportunistic bacterial infections around the world. Rising antibiotic resistance and few alternative methods of treatment are just two looming problems associated with clinical management of S ...
Eileen A Larkin +2 more
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Induction of murine cytolytic T lymphocytes by Pseudomonas aeruginosa exotoxin A [PDF]
Infection and Immunity, 1988 Pseudomonas aeruginosa exotoxin A (PA), a potent protein synthesis inhibitor, was found to be a weak T-cell mitogen for murine splenocytes. Maximal stimulation of [3H]thymidine incorporation was obtained with 10 to 100 ng of toxin per ml following a 4-day induction.
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Transient Low T Cell Response to Streptococcal Pyrogenic Exotoxin-C in Patients with Kawasaki Disease [PDF]
Pediatric Research, 1998 Superantigens (SAs) are known to induce transient anergy followed by T cell activation. Recent reports have suggested that SAs are involved in the pathogenesis of Kawasaki disease (KD). In the present study, we investigated the peripheral T cell response to SAs by measuring proliferation and IL-2 production to determine whether the T cell anergy is ...
K, Masuda +5 more
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Toxins, 2020 Diphtheria toxin, an exotoxin secreted by Corynebacterium that causes disease in humans by inhibiting protein synthesis, enters the cell via receptor-mediated endocytosis. The subsequent endosomal acidification triggers a series of conformational changes,
Mykola V. Rodnin +5 more
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N-terminus of flagellin enhances vaccine efficacy against Actinobacillus pleuropneumoniae
BMC Veterinary Research, 2022 Background Flagellin elicits potent immune response and may serve as a vaccine adjuvant. We previously reported that the N-terminus of flagellin (residues 1–99, nFliC) is sufficient for vaccine efficacy enhancement against Pasteurella multocida challenge
Kamonpun Chuekwon +2 more
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Zinc Binding and Dimerization of Streptococcus pyogenes Pyrogenic Exotoxin C Are Not Essential for T-cell Stimulation [PDF]
Journal of Biological Chemistry, 2003 Streptococcal pyrogenic enterotoxin C (Spe-C) is a superantigen virulence factor produced by Streptococcus pyogenes that activates T-cells polyclonally. The biologically active form of Spe-C is thought to be a homodimer containing an essential zinc coordination site on each subunit, consisting of the residues His(167), His(201), and Asp(203 ...
Wieslaw, Swietnicki +3 more
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Cholera Toxin Promotes Th17 Cell Differentiation by Modulating Expression of Polarizing Cytokines and the Antigen-Presenting Potential of Dendritic Cells. [PDF]
PLoS ONE, 2016 Cholera toxin (CT), an exotoxin produced by Vibrio cholera, acts as a mucosal adjuvant. In a previous study, we showed that CT skews differentiation of CD4 T cells to IL-17-producing Th17 cells. Here, we found that intranasal administration of CT induced
Jung-Ok Kang, Jee-Boong Lee, Jun Chang
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Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A [PDF]
Proceedings of the National Academy of Sciences, 2012 Recombinant immunotoxins (RITs) are chimeric proteins that are being developed for cancer treatment. We have produced RITs that contain PE38, a portion of the bacterial protein Pseudomonas exotoxin A.
Ronit, Mazor +8 more
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