Results 101 to 110 of about 109,706 (265)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Recent molecular approaches to understanding astrocyte function in vivo

Frontiers in Cellular Neuroscience, 2013
Astrocytes are a predominant glial cell type in the nervous systems, and are becoming recognized as important mediators of normal brain function as well as neurodevelopmental, neurological, and neurodegenerative brain diseases.
David eDavila, Karine eThibault, Todd A Fiacco, Cendra eAgulhon   +3 more
doaj   +1 more source

What does the functional-structural plant model HydroShoot tell us about the reasons for photosynthesis depression in grapevine (​Vitis vinifera​ L.)photosynthesis depression? [PDF]

, 2017
Grapevine is a species that get along with water deficit. Yet, it cannot always stand thirst when accompanied by high temperatures, reducing noticeably its gas-exchange rates. Elucidating the origins of this reduction is a challenge, regarded the complex
Albasha, Rami, Fournier, Christian, Lebon, Eric, Pradal, Christophe, Simonneau, Thierry   +4 more
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

La paille de riz dans l'alimentation animale au Sénégal. I. Analyses bromatologiques, digestibilité in vivo et in vitro, bilans azotés et minéraux [PDF]

, 1974
La paille de riz est un fourrage abondant au Sénégal: 150 000 t sont disponibles à l'heure actuelle et ces quantités doivent doubler dans les dix années à venir.
Boudergues, R., Calvet, Henry, Chambon, J., Diallo, S., Friot, Dominique, Valenza, Jean   +5 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Analyse de la peau à l'aide de l'imagerie multispectrale: suivi de lentigos : revue empirique [PDF]

, 2017
Introduction : Dans un contexte d’avancées technologiques dans le domaine de l’optique au service de la médecine, l’équipe du professeur Martial Geiser, du domaine Ingénierie et Architecture de la HES-SO Valais/Wallis, a réalisé cette étude.
Carruzzo, Olivier, Fournier, Claude-Alexandre, Valfredini, Jennie   +2 more
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Les composés phénoliques dans la résistance des pommes à l'infection par les Pezicula malicorticis et p. Alba [PDF]

, 1974
Il existe trois phases essentielles dans la résistance des pommes à l'infection par Pezicula. Dans la première, la teneur en composés phénoliques (leucoanthocyanines, acide chlorogénique) est déterminante en présence d'un pH bas.
Bompeix, G., Bousquet, Jean-François
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source