Results 81 to 90 of about 109,706 (265)

Using modern reproductive technologies such as embryo transfer and artificial insemination to improve the reproductive potential of dromedary camels [PDF]

, 2000
Les premiers essais ont évalué le dilueur optimum pour le sperme du dromadaire. Les éjaculats de dromadaires mâles recueillis ont été dilués à 1 :1 avec un tampon vert, du Laciphos ou du glucose de lait écrémé.
Allen, W.R., Billah, A.M., Skidmore, J.A.   +2 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Les incertitudes scientifiques et techniques constituent-elles une source possible de renouvellement de la vie démocratique ?

, 2012
http://www.csi.mines-paristech.fr/Items/WorkingPapers/Download/DLWP.php?wp=WP_CSI_028.pdfTexte de la conférence introductive au Congrès de l'AISFL organisé à Rabat en juillet 2012 sur le thème : Penser l ...
Callon, Michel
core   +1 more source

Existence chez la pomme de terre de résistance induite vis-à-vis de Globodera rostochiensis [PDF]

, 1994
Le mécanisme de résistance à #G. rostochiensis$ Ro1/4 de deux génotypes ex-#vernei$ de pomme de terre et leurs parents est étudié selon diverses méthodologies.
Balandras, C., Mugniéry, D., Rousselle, P.   +2 more
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Integrating experimentation and quantitative modeling to enhance discovery of beta amyloid (Aβ) lowering therapeutics for Alzheimer’s disease

Frontiers in Pharmacology, 2012
Drug discovery can benefit from a proactive-knowledge-attainment philosophy which strategically integrates experimentation and pharmacokinetic/pharmacodynamic (PK/PD) modeling.
Yasong eLu
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Valeur schistosomicide d'un nouveau dérivé aminonitrothiazole le CIBA 32.644/Ba ou ANT [PDF]

, 1965
Des essais thérapeutiques et toxiques faits avec un nouveau dérivé aminonitrothiazole, le 32.644/Ba CIBA ou ANT, sur ovins et caprins infestés naturellement de schistosomiase intestinale démontrent l'excellente action anti-bilharzienne de ce produit.
Grétillat, Simon
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source