Results 81 to 90 of about 501,356 (299)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Synchronization versus stability of the invariant distribution for a class of globally coupled maps

, 2018
We study a class of globally coupled maps in the continuum limit, where the individual maps are expanding maps of the circle. The circle maps in question are such that the uncoupled system admits a unique absolutely continuous invariant measure (acim ...
Bálint, Péter, Keller, Gerhard, Sélley, Fanni M., Tóth, Imre Péter   +3 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

"Anomaly" in n=infinity Alday-Maldacena Duality for Wavy Circle

, 2008
If the Alday-Maldacena version of string/gauge duality is formulated as an equivalence between double loop and area integrals a la arXiv: 0708.1625, then this pure geometric relation can be tested for various choices of n-side polygons.
Itoyama, H., Mironov, A., Morozov, A.
core   +1 more source

The Expanding Circle of Contract Law

SSRN Electronic Journal, 2016
People and corporations are increasingly held liable in private law for the external effects of their actions, in particular in cases that involve some fundamental aspect of “justice” such as severe violations of labour standards or threats to the environment.
openaire   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Hyperbolic attractor in a system of coupled non-autonomous van der Pol oscillators: Numerical test for expanding and contracting cones

, 2006
We present numerical verification of hyperbolic nature for chaotic attractor in a system of two coupled non-autonomous van der Pol oscillators (Kuznetsov, Phys. Rev. Lett., 95, 144101, 2005).
Afraimovich, Afraimovich, Andronov, Anishchenko, Arnol'd, Belykh, Benettin, Bunimovich, Devaney, Eckmann, Hairer, Hunt, Hunt, I.R. Sataev, Katok, Kuznetsov, Kuznetsov, Mischaikow, Ott, S.P. Kuznetsov, Shil'nikov, Shilnikov, Sinai   +22 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Monotone Families of Circle Diffeomorphisms Driven by Expanding Circle Maps

Communications in Mathematical Physics
AbstractWe consider monotone families of circle diffeomorphisms forced by the strongly chaotic circle endomorphisms $$x\mapsto bx \mod 1$$ x ↦ b x mod 1
Kristian Bjerklöv, Raphaël Krikorian
openaire   +2 more sources