Results 141 to 150 of about 1,860,920 (244)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Ciclos de negocios en Colombia, 1975-2011

Lecturas de Economía, 2013
Se propone una cronología para los ciclos de negocios de Colombia en la concepción clásica del NBER; esto es, determinando las fechas de picos y valles en la actividad económica sin separar las series utilizadas en sus componentes transitorio y ...
Viviana Alfonso, Luis Eduardo Arango, Fernando Arias, Guillermo Cangrejo, José David Pulido   +4 more
doaj  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Association of medicaid expansion with lung cancer-specific and overall mortality: A difference-in-differences analysis. [PDF]

PLoS One
Akinyemi O, Fasokun M, Eze A, Ugochukwu N, Arshad S, Belie O, Hughes K, Cornwell Iii E, Levy G.   +8 more
europepmc   +1 more source

Expansión en ortodoncia [PDF]

, 2016
D. Costa del Río
core   +1 more source

La incorporación de Arabia Saudita en los BRICS

Política Internacional
Dos de los objetivos cardinales de la XV Cumbre del BRICS fueron la expansión del grupo y la desdolarización de la economía mundial, incluida la promoción de monedas locales en el comercio intra-bloque. En estas aspiraciones, juega un rol fundamental la
Sofia Miranda González , Alberto Blanco Peñate   +1 more
doaj  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Inflating Your Success: An Algorithmic Approach to Improving Outcomes in Pediatric Tissue Expansion. [PDF]

Plast Reconstr Surg Glob Open
Green JC, Ruiz SG, Swiekatowski KR, Wang EB, Won P, Obinero CG, Do T, Sobol D, Greives MR.   +8 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source