Results 91 to 100 of about 3,019,422 (250)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Network Pharmacology and Experimental Verification Reveal the Regulatory Mechanism of Chuanbeimu in Treating Chronic Obstructive Pulmonary Disease

International Journal of COPD
Meilan Xian,1,2,* Jiaoyuan Xu,1,3,* Yamei Zheng,4 Lei Zhang,4 Jie Zhao,4 Jie Chen,1 Siguang Li,1 Lingsang Lin,1 Yi Zhong,4 Zehua Yang,4 Tian Xie,4 Linhui Huang,4 Yipeng Ding1,4 1Department of General Practice, Hainan Affiliated Hospital of Hainan
Xian M, Xu J, Zheng Y, Zhang L, Zhao J, Chen J, Li S, Lin L, Zhong Y, Yang Z, Xie T, Huang L, Ding Y   +12 more
doaj  

Experiment and verification of fine gridded precipitation forecast fusion correction in Sichuan

暴雨灾害
Fine-scale quantitative precipitation forecast is a key issue and challenge in weather forecasting services. In this study, based on hourly precipitation from the 1 km× 1 km resolution Southwest China WRF-based Intelligent Numeric Grid forecast System ...
Wulong ZHANG, Chaoping CHEN, Kangquan YANG   +2 more
doaj   +1 more source

Annual report, Agricultural Experiment Station, University of Minnesota, 1893

, 1894
1 electronic resource (PDF, xxii pages)University of Minnesota. Agricultural Experiment Station. (1894). Annual report, Agricultural Experiment Station, University of Minnesota, 1893.
University of Arizona. Agricultural Experiment Station., University of Minnesota. Agricultural Experiment Station   +1 more
core  

Truth and Verification [PDF]

, 2011
List of Web sites, movies, TV shows, books, and SBU courses that deal with truth and verification. 4 pages.Truth and Verification Lecture Trailheads -- lecture-8-truth-and-ver-trailheads.pdfThe work(s) contained within this record have been analyzed and ...
Rosenfeld, Adam
core  

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Perceptual representations in L1 and L2 spatial and abstract language processing: applying an innovative sentence-diagram verification paradigm

Frontiers in Human Neuroscience
IntroductionPerceptual representations in language comprehension were examined using sentence-picture verification tasks. However, concerns have been raised regarding the suitability of concrete pictures for representing abstract concepts compared to ...
Menghan Wang, Helen Zhao
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

AI verification experiment

we conducted a 2 (fact-checking source: AI vs. human) × 2 (referencing: present vs. absent) × 2 (verification accuracy: appropriate verification vs.
Jiahui Lu
core  

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source