Results 71 to 80 of about 2,368 (218)

Dynamic modeling of double-helical gear with Timoshenko beam theory and experiment verification

open access: yesAdvances in Mechanical Engineering, 2016
In the dynamic study of the double-helical gear transmission, the coupling shaft in the middle of the two helical gears is difficult to be handled accurately.
Jincheng Dong   +3 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Joint simulation and experimental verification of electromechanical-hydraulic of hydraulic excavator working device

open access: yesScientific Reports
To rigorously evaluate the electromechanical-hydraulic coupling performance of a hydraulic excavator’s working device under authentic operating loads, this study presents a field-data-driven co-simulation framework applied to a 20-ton backhoe hydraulic ...
Mei Xin   +6 more
doaj   +1 more source

Transient characteristics verification method for DC transformer used in flexible HVDC system

open access: yesGlobal Energy Interconnection, 2019
Previous studies have proposed higher requirements for the transient characteristics of a DC transformer used in a flexible high-voltage direct current (HVDC) system to achieve faster sampling speed and meet wider bandwidth requirements of the control ...
Qi Nie   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Experiment and verification of fine gridded precipitation forecast fusion correction in Sichuan

open access: yes暴雨灾害
Fine-scale quantitative precipitation forecast is a key issue and challenge in weather forecasting services. In this study, based on hourly precipitation from the 1 km× 1 km resolution Southwest China WRF-based Intelligent Numeric Grid forecast System ...
Wulong ZHANG   +2 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Network Pharmacology and Experimental Verification Reveal the Regulatory Mechanism of Chuanbeimu in Treating Chronic Obstructive Pulmonary Disease

open access: yesInternational Journal of COPD
Meilan Xian,1,2,* Jiaoyuan Xu,1,3,* Yamei Zheng,4 Lei Zhang,4 Jie Zhao,4 Jie Chen,1 Siguang Li,1 Lingsang Lin,1 Yi Zhong,4 Zehua Yang,4 Tian Xie,4 Linhui Huang,4 Yipeng Ding1,4 1Department of General Practice, Hainan Affiliated Hospital of Hainan
Xian M   +12 more
doaj  

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