Results 211 to 220 of about 49,920 (245)

Neuroendocrine Influences on Experimental Autoimmune Encephalomyelitis

Annals of the New York Academy of Sciences, 1998
Abstract: Experimental autoimmune encephalomyelitis (EAE), a model for human multiple sclerosis, is an inflammatory disease of the CNS mediated by autoreactive T lymphocytes directed against the neuroantigen, myelin basic protein (MBP). EAE is inducible in the Lewis rat, which exhibits an acute monophasic disease, and in selected mouse strains, which ...
C C, Whitacre, K, Dowdell, A C, Griffin
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Suppression of experimental autoimmune encephalomyelitis by sulfasalazine

Acta Neurologica Scandinavica, 2009
It has recently been suggested that the sulfidopeptide leukotriene C4 (LTC4), a 5-lipoxygenase product of the arachidonic acid metabolism and one of the most potent mediators of vascular permeability, might be involved in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS).
M, Prosiegel, I, Neu, S, Vogl, G, Hoffmann, A, Wildfeuer, G, Ruhenstroth-Bauer   +5 more
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Role of orexin-A in experimental autoimmune encephalomyelitis

Journal of Neuroimmunology, 2016
The aim of this study was to evaluate the effects of orexin-A (OX-A) on behavioral and pathological parameters and on gene expression of some multiple sclerosis-related peptides in a model of experimental autoimmune encephalomyelitis (EAE). EAE was induced by subcutaneous administration of MOG 35-55.
Iman, Fatemi, Ali, Shamsizadeh, Fatemeh, Ayoobi, Zahra, Taghipour, Mohammad Hossein, Sanati, Ali, Roohbakhsh, Manijeh, Motevalian   +6 more
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Neuroprotection by Ulinastatin in Experimental Autoimmune Encephalomyelitis

Neurochemical Research, 2011
Ulinastatin has previously been used as a drug for patients with acute inflammatory disorders. The goal of the present study was to investigate the protective effects of ulinastatin on myelin sheaths and oligodendrocytes in experimental autoimmune encephalomyelitis (EAE), and to explore the possible underlying mechanism.
Yaqing, Shu, Yu, Yang, Wei, Qiu, Zhengqi, Lu, Ying, Li, Jian, Bao, Ming, Feng, Xueqiang, Hu   +7 more
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Gene Therapy in Experimental Autoimmune Encephalomyelitis

Journal of Clinical Immunology, 2000
Gene therapy traditionally has been associated with "gene replacement." where exogenous recombinant DNA is introduced ex vivo into somatic cells that are then introduced back into the patient as a way to correct an inherited genetic defect. However, several novel gene therapy strategies for treating autoimmune diseases recently have emerged. Strategies
P M, Mathisen, V K, Tuohy
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Behavioral aspects of experimental autoimmune encephalomyelitis

Journal of Neuroimmunology, 2000
Acute inflammation is known to induce a depressive-like sickness behavior syndrome in humans and in experimental animals. In the present study, we sought to determine whether a chronic neuroautoimmune inflammation is also associated with a similar behavioral syndrome.
Y, Pollak, H, Ovadia, I, Goshen, R, Gurevich, K, Monsa, R, Avitsur, R, Yirmiya   +6 more
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Oral Tolerance in Experimental Autoimmune Encephalomyelitis

Annals of the New York Academy of Sciences, 1996
In work performed by a number of laboratories, it has become quite clear that the oral administration of autoantigens exerts a profoundly suppressive effect on the development and long-term clinical course of autoimmune disease. Specific peptide sequences derived from the autoantigens are similarly suppressive.
C C, Whitacre, I E, Gienapp, A, Meyer, K L, Cox, N, Javed   +4 more
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The Role of Cytokines in Experimental Autoimmune Encephalomyelitis

2001
Experimental autoimmune encephalomyelitis (EAE) is an animal model of the demyelinating disease multiple sclerosis. In EAE cytokines play a critical role in defining the Th1 or Th2 nature of the autoantigen directed immune response, and in propagating and regulating inflammation within the central nervous system. In this review we summarize some of the
Nicholson, LB, Bettelli, E
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Reinduction of Experimental Autoimmune Encephalomyelitis in Mice

Cellular Immunology, 1995
Experimental autoimmune encephalomyelitis (EAE) in Lewis rats and some strains of mice is typically a monophasic disease, and recovered animals are resistant to reinduction of disease. We demonstrate that SJL mice remain susceptible to disease after recovery, and suffer a second episode of disease when reinjected with spinal cord homogenate in complete
J W, Lindsey, M, Pappolla, L, Steinman
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Experimental Allergic Encephalomyelitis and Autoimmune Disease

1966
Publisher Summary This chapter discusses experimental autoimmunity using experimental allergic encephalomyelitis as a prototype. This experimental disease makes possible a firsthand presentation both of its well-established facets, such as the production of the disease and the source and character of the antigen, and also of the still outstanding ...
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