Results 251 to 260 of about 81,192 (267)

Neuroendocrine Influences on Experimental Autoimmune Encephalomyelitis

Annals of the New York Academy of Sciences, 1998
Abstract: Experimental autoimmune encephalomyelitis (EAE), a model for human multiple sclerosis, is an inflammatory disease of the CNS mediated by autoreactive T lymphocytes directed against the neuroantigen, myelin basic protein (MBP). EAE is inducible in the Lewis rat, which exhibits an acute monophasic disease, and in selected mouse strains, which ...
Kennichi C. Dowdell, Ann C. Griffin, Caroline C. Whitacre   +2 more
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The origin and application of experimental autoimmune encephalomyelitis [PDF]

Nature Reviews Immunology, 2007
Experimental autoimmune encephalomyelitis (EAE) is a model of the neuroimmune system responding to priming with central nervous system (CNS)-restricted antigens. It is an excellent model of post-vaccinal encephalitis and a useful model of many aspects of multiple sclerosis.
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Reinduction of Experimental Autoimmune Encephalomyelitis in Mice

Cellular Immunology, 1995
Experimental autoimmune encephalomyelitis (EAE) in Lewis rats and some strains of mice is typically a monophasic disease, and recovered animals are resistant to reinduction of disease. We demonstrate that SJL mice remain susceptible to disease after recovery, and suffer a second episode of disease when reinjected with spinal cord homogenate in complete
J. William Lindsey, Miguel A. Pappolla, Lawrence Steinman   +2 more
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The Role of Cytokines in Experimental Autoimmune Encephalomyelitis

2001
Experimental autoimmune encephalomyelitis (EAE) is an animal model of the demyelinating disease multiple sclerosis. In EAE cytokines play a critical role in defining the Th1 or Th2 nature of the autoantigen directed immune response, and in propagating and regulating inflammation within the central nervous system. In this review we summarize some of the
Nicholson, LB, Bettelli, E
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Acamprosate modulates experimental autoimmune encephalomyelitis

Inflammopharmacology, 2011
This pilot study aimed to determine the efficacy of acamprosate (N-acetyl homotaurine) in reducing the pathological features of experimental autoimmune encephalomyelitis (EAE) which is an animal model for multiple sclerosis (MS).The amino acid taurine has multiple biological activities including immunomodulation and neuromodulation.
Z, Sternberg, A, Cesario, K, Rittenhouse-Olson, R A, Sobel, Yi-Kan, Leung, O, Pankewycz, B, Zhu, T, Whitcomb, D S, Sternberg, F E, Munschauer   +9 more
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Neuroprotection by Ulinastatin in Experimental Autoimmune Encephalomyelitis

Neurochemical Research, 2011
Ulinastatin has previously been used as a drug for patients with acute inflammatory disorders. The goal of the present study was to investigate the protective effects of ulinastatin on myelin sheaths and oligodendrocytes in experimental autoimmune encephalomyelitis (EAE), and to explore the possible underlying mechanism.
Jian Bao, Wei Qiu, Xueqiang Hu, Ming Feng, Yu Yang, Yaqing Shu, Ying Li, Zhengqi Lu   +7 more
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Suppression of experimental autoimmune encephalomyelitis by sulfasalazine

Acta Neurologica Scandinavica, 2009
It has recently been suggested that the sulfidopeptide leukotriene C4 (LTC4), a 5-lipoxygenase product of the arachidonic acid metabolism and one of the most potent mediators of vascular permeability, might be involved in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS).
Georg Hoffmann, Mario Prosiegel, S. Vogl, Ingo S. Neu, G. Ruhenstroth-Bauer, A. Wildfeuer   +5 more
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Behavioral aspects of experimental autoimmune encephalomyelitis

Journal of Neuroimmunology, 2000
Acute inflammation is known to induce a depressive-like sickness behavior syndrome in humans and in experimental animals. In the present study, we sought to determine whether a chronic neuroautoimmune inflammation is also associated with a similar behavioral syndrome.
Haim Ovadia, Raz Yirmiya, Yehuda Pollak, Keren Monsa, Inbal Goshen, Ronit Avitsur, Ronnie Gurevich   +6 more
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Oral Tolerance in Experimental Autoimmune Encephalomyelitis

Annals of the New York Academy of Sciences, 1996
In work performed by a number of laboratories, it has become quite clear that the oral administration of autoantigens exerts a profoundly suppressive effect on the development and long-term clinical course of autoimmune disease. Specific peptide sequences derived from the autoantigens are similarly suppressive.
Ingrid E. Gienapp, Caroline C. Whitacre, Karen Cox, Najma Javed, Abbie L. Meyer   +4 more
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Experimental Murine Autoimmune Encephalomyelitis

1979
Experimental autoimmune (allergic) encephalomyelitis is an inflammatory and demyelinating disease of the central nervous system (CNS) mediated by the cellular component of the immune response. EAE is induced in laboratory animals when CNS tissue homogenates or myelin are injected together with oil adjuvants containing mycobacteria (Freund’s complete ...
Ian R. Mackay, D. S. Linthicum, P. R. Carnegie   +2 more
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