Results 151 to 160 of about 2,734 (194)

Treatment of experimental autoimmune uveoretinitis with atorvastatin and lovastatin

Experimental Eye Research, 2007
Statins, which are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, are approved for cholesterol reduction and are commonly used to treat atherosclerosis and coronary artery disease. Statins may also be potent immunomodulatory agents and may be beneficial in the treatment of autoimmune diseases.
Hideo, Kohno, Tsutomu, Sakai, Saburo, Saito, Kiichiro, Okano, Kenji, Kitahara   +4 more
openaire   +2 more sources

Intraocular cytokine quantification of experimental autoimmune uveoretinitis in rats

Ocular Immunology and Inflammation, 1998
Elevations of inflammatory cytokines have been implicated in the pathogenesis of experimental autoimmune uveoretinitis (EAU) in rats, although such analysis has relied on indirect methods of assessment such as measurement of mRNA content. In this study, we examined the feasibility of directly measuring cytokine concentrations in intraocular extracts ...
A A, Okada, J, Sakai, M, Usui, J, Mizuguchi   +3 more
openaire   +2 more sources

Suppression of Experimental Autoimmune Uveoretinitis by Dietary Calorie Restriction

Japanese Journal of Ophthalmology, 2001
To investigate the inhibitory effect of dietary calorie restriction on experimental autoimmune uveoretinitis (EAU) in rats, and its mechanism. Lewis rats were maintained on a 50% calorie-restricted diet for 2 months or 6 months. The control group was maintained on a 90% ad libitum intake for the same length of time.
T, Abe, A, Nakajima, N, Satoh, M, Ohkoshi, S, Sakuragi, A, Koizumi   +5 more
openaire   +2 more sources

The dynamics of leukocyte infiltration in experimental autoimmune uveoretinitis

Progress in Retinal and Eye Research, 2008
Experimental autoimmune uveoretinitis (EAU) serves as an animal model for human uveitis. EAU is inducible in animals by peripheral immunization with proteins found in the retina that triggers an immune response which leads to tissue damage. This is coordinated by autoantigen specific CD4(+) T cells whose activation is accompanied by the infiltration of
Kerr, EC, Copland, DA, Dick, AD, Nicholson, LB   +3 more
openaire   +3 more sources

Evidence for immediate hypersensitivity phenomena in experimental autoimmune uveoretinitis

European Journal of Immunology, 1981
AbstractEvidence is presented for the involvement of immediate hypersensitivity phenomena in experimental autoimmune uveoretinitis, an ocular inflammatory disease induced in Lewis rats by injection of the purified S antigen from bovine retina. Several parameters at various dates after immunization have been studied.
Y, de Kozak, J, Sainte-Laudy, J, Benveniste, J P, Faure   +3 more
openaire   +2 more sources

Oral administration of interferon-β suppresses experimental autoimmune uveoretinitis

Graefe's Archive for Clinical and Experimental Ophthalmology, 2002
The oral administration of type I interferons (IFNs) have been reported to reduce severity of inflammation in several animal models of autoimmune disease. This study examined whether oral administration of IFN-beta is capable of modulating inflammation in experimental autoimmune uveoretinitis (EAU).EAU was induced in rats by immunization with ...
Jun, Suzuki, Jun-Ichi, Sakai, Annabelle A, Okada, Eiko, Takada, Masahiko, Usui, Junichiro, Mizuguchi   +5 more
openaire   +2 more sources

Immunosuppression by Gramicidin S of Experimental Autoimmune Uveoretinitis, Pinealitis and Autoimmune Encephalomyelitis

Journal of Ocular Pharmacology and Therapeutics, 1990
Using an in vitro lymphocyte proliferation assay we screened several cyclic peptide antibiotics (bacitracin, oleandomycin, capreomycin, colistin, virginiamycin, and gramicidin S) for their immunosuppressive activity. Gramicidin S (GrS) was found to inhibit [3H]-thymidine incorporation into concanavalin A-stimulated and E coli lipopolysaccharide ...
S, Matsushima, T, Yoshitoshi, H, Shichi
openaire   +2 more sources

Tissue Repair in the Iris in Experimental Autoimmune Uveoretinitis

Experimental and Molecular Pathology, 1995
Our previous work on rats with S-antigen-induced experimental autoimmune uveoretinitis showed iris tissue changes involving infiltration of inflammatory cells, destruction of the iris architecture, and breakdown of the blood-retinal barrier. The present study reports the remarkable ability of the iris to regenerate during the postinflammatory period ...
J, Wang, E, Essner, H, Shichi
openaire   +2 more sources

TH2 activated cells prevent experimental autoimmune uveoretinitis, a TH1‐dependent autoimmune disease

European Journal of Immunology, 1993
AbstractMercuric chloride (HgCl2) injections protect (Lewis x Brown‐Norway) F1 (F1) rats against experimental autoimmune uveoretinitis (EAU) induced by immunization with the retinal S antigen (S‐Ag); in contrast HgCl2‐injected F1 rats develop EAU following transfer of lymph node (LN) cells from rats immunized with S‐Ag alone.
Saoudi, Abdelhadi, Kuhn, Joelle, Druet, Philippe, Bellon, Blanche, Huygen, Kris, De Kozak, Yvonne, Velu, Thierry, Goldman, Michel   +7 more
openaire   +2 more sources

Anti-inflammatory effect of retinoic acid on experimental autoimmune uveoretinitis

British Journal of Ophthalmology, 2009
To determine whether an active metabolite of vitamin A, all-trans retinoic acid (ATRA), reduces inflammation in experimental autoimmune uveoretinitis (EAU).Naive CD4(+) T cells were activated with anti-CD3, anti-CD28 and transforming growth factor (TGF)-beta, in the presence or absence of ATRA.
Hiroshi, Keino, Takayo, Watanabe, Yasuhiko, Sato, Annabelle A, Okada   +3 more
openaire   +2 more sources