Results 71 to 80 of about 6,030,066 (175)

Leishmaniasis in rheumatoid arthritis

Reumatismo, 2011
Leishmaniasis represents a complex of diseases with an important clinical and epidemiological diversity. Visceral leishmaniasis is of higher priority than cutaneous leishmaniasis as it is a fatal disease in the absence of treatment. The clinical spectrum
M. Cutolo, M.E. Secchi, C. Pizzorni
doaj   +1 more source

Medicinal and Crop Protection Chemistry: Breaking Barriers, Building Synergies

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A unified view of medicinal and crop protection chemistry reveals shared scientific progress, common challenges, and new opportunities for cross‐disciplinary collaboration. Bridging expertise across both fields could accelerate innovation and actively encourage more sustainable solutions.
Giulia Cazzaniga, Giusy L. Fratello, Alexander T. Apostle, Roberto Orru, David M. Barber, Silvia Gazzola   +5 more
wiley   +1 more source

HetCA/STOCSY‐Guided Dereplication of Artemisia arborescens Reveals Furofuran Lignans with Antileishmanial Effects

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Bioactive metabolites can remain hidden in negligible activity extracts. A statistical spectroscopy–driven dereplication workflow integrating the HeteroCovariance Approach (HetCA) and Statistical Total Correlation Spectroscopy (STOCSY) prioritized furofuran lignans in Artemisia arborescens, identifying three compounds with moderate antileishmanial ...
Olga Karoutzou, Stavros Beteinakis, Olga Koutsoni, Despina Smirlis, Maria Halabalaki, Leandros Alexios Skaltsounis, Emmanuel Mikros   +6 more
wiley   +1 more source

Nota sobre infecção natural de Oryzomys capito laticeps em foco enzoótico de leishmaniose tegumentar no Estado de São Paulo, Brasil Natural infection of Oryzomys capito laticeps in enzootic focus of cutaneous leishmaniasis in S. Paulo State, Brazil

Revista de Saúde Pública, 1973
Assinala-se o isolamento de cepa de Leishmania braziliensis braziliensis em exemplar de Oryzomys capito laticeps capturado em foco enzoótico do Estado de São Paulo, Brasil.
Oswaldo Paulo Forattini, Dino B. G. Pattoli, Ernesto Xavier Rabello, Octávio Alves Ferreira   +3 more
doaj   +1 more source

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, Volume 15, Issue 30, 14 August 2026.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

Leishmania major Infection in Humanized Mice Induces Systemic Infection and Provokes a Nonprotective Human Immune Response [PDF]

, 2012
Background: Leishmania (L.) species are the causative agent of leishmaniasis. Due to the lack of efficient vaccine candidates, drug therapies are the only option to deal with cutaneous leishmaniasis.
Uwe Ritter (130470), Schmid, Maximilian, Hanses Frank, Ulrike Schleicher (104689), Frank Hanses, Maximilian Schmid, Florian, Christian, Frank Hanses (148604), Zimara Nicole, Wolfgang Ernst (13060), Wege, Anja Kathrin, Anja Kathrin Wege, Anja Kathrin Wege (148586), Christian Florian, Ernst, Wolfgang, Uwe Ritter, Hanses, Frank, Maximilian Schmid (148609), Florian Christian, Ritter Uwe, Nicole Zimara (148595), Zimara, Nicole, Christian Florian (148590), Schleicher, Ulrike, Ritter, Uwe, Nicole Zimara, Ernst Wolfgang, Schmid Maximilian, Schleicher Ulrike, Wege Anja Kathrin, Wolfgang Ernst, Ulrike Schleicher   +31 more
core   +2 more sources

Dicentrine, an Aporphine Alkaloid From Ocotea langsdorffii, Induces Mitochondrial Dysfunction and Oxidative Stress in Leishmania (L.) infantum

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
Dicentrine, an aporphine alkaloid, exhibits potent in vitro antileishmanial activity against Leishmania species with high selectivity and low macrophage cytotoxicity. Mechanistic studies reveal that the compound triggers parasite death possibly by inducing mitochondrial membrane disruption and oxidative stress.
Camila S. de Freitas, Eduardo Oliveira S. da Silva, Daniela C. Tristão, Guilherme M. Antar, Daniela P. Lage, Dóris M. Abrão, Luciana M. Ribeiro Antinarelli, Elaine S. Coimbra, João Henrique G. Lago, Eduardo A. F. Coelho   +9 more
wiley   +1 more source

Treatment of localised cutaneous Leishmania tropica infection in Aleppo, Syria and drug sensitivity of clinical isolates [PDF]

Anthroponotic cutaneous leishmaniasis caused by Leishmania tropica has been endemic in Aleppo, Syria for centuries. The first modem description of the disease was also done in Aleppo.
Abazid, Nizar
core   +1 more source

Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG [PDF]

, 2004
Sand flies are the exclusive vectors of the protozoan parasite Leishmania, but the mechanism of transmission by fly bite has not been determined nor incorporated into experimental models of infection.
Bates, Paul A., Ilg, T., Nikolaev, Andrei V., Ferguson, Michael AJ, Andrei V. Nikolaev, Matthew E. Rogers, Ilg, Thomas, Ferguson, Michael A. J.; id_orcid, Ferguson, M. A. J., Rogers, Matthew E., Ferguson, Michael A J, Paul A. Bates, Michael A. J. Ferguson, Rogers, Matthew E, Thomas Ilg, Bates, Paul, Nikolaev, Andrei V, Bates, Paul A, Nikolaev, A. V.   +18 more
core   +1 more source

Infecção natural de flebotomíneos em foco enzoótico de leishmaniose tegumentar no Estado de São Paulo, Brasil Natural infections of Phlebotominae sandflies in a enzootia focus of cutaneous leishmaniasis in S. Paulo State, Brasil

Revista de Saúde Pública, 1972
Relata-se o encontro de infecções naturais de Pintomyia pessoai e Psychodopygus intermedius em foco enzoótico de leishmaniose tegumentar no Estado de São Paulo, Brasil.
Oswaldo Paulo Forattini, Dino B. G. Pattoli, Ernesto Xavier Rabello, Octavio Alves Ferreira   +3 more
doaj   +1 more source