Results 51 to 60 of about 144,130 (263)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Influence of additional static stresses on biaxial low-cycle fatigue of 2024 aluminum alloy

open access: yesFracture and Structural Integrity, 2022
In this paper, a previously developed modification of the Sainz model of multiaxial fatigue is reduced to an invariant form. Model constants were determined for different sets of setup experiments.
Andrey Yankin   +4 more
doaj   +2 more sources

Influence of static mean stresses on the fatigue behavior of 2024 aluminum alloy under multiaxial loading

open access: yesFracture and Structural Integrity, 2020
Axial alternating fatigue tests with superimposed static torsional mean stress and shear alternating fatigue tests with superimposed static tensile mean stress are represented.
Andrey Yankin   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Measuring strain in sheet metals [PDF]

open access: yesFME Transactions, 2019
A sensitive and precise experimental system able to time-track the static and dynamic response of steel sheets to intense loads is hereby described.
Braut Sanjin   +3 more
doaj  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Experimental Fluid Mechanics 2019 [PDF]

open access: yesEPJ Web of Conferences, 2022
Dančová Petra
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

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