Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Analysis of a Vibrating Beam Structure in the Context of Hands-On Teaching in Structural Dynamics
Journal of Experimental and Theoretical AnalysesTo demonstrate the difference between non-ideal experiments and idealized analytical models, bending vibrations of a frame structure have been analyzed in the context of hands-on teaching in structural dynamics. Both experimental modal analysis and model-
Thomas Kletschkowski
doaj +1 more source
Experimental Modal Analysis and Characterization of Additively Manufactured Polymers. [PDF]
Polymers (Basel), 2022 Nguyen HT +3 more
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Experimental dynamic analysis of the footbridge across Jizera River in Mladá Boleslav
Acta Polytechnica CTU ProceedingsThe text of this submitted paper is devoted to the experimental dynamic analysis of the newly designed footbridge across the Jizera River in Mladá Boleslav.
Miroslav Čáp +3 more
doaj +1 more source
Measurement of Acceleration Response Functions with Scalable Low-Cost Devices. An Application to the Experimental Modal Analysis. [PDF]
Sensors (Basel), 2021 Magdaleno A +4 more
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Performance of Optical Structural Vibration Monitoring Systems in Experimental Modal Analysis. [PDF]
Sensors (Basel), 2021 Kalybek M, Bocian M, Nikitas N.
europepmc +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Combined Estimation of Structural Displacement, Rotation and Strain Modes on a Scaled Glider
Applied SciencesIncorporating sensors such as microelectromechanical system (MEMS)-based inertial measurement units (IMUs) and strain gauges into aircraft structures has the potential to complement ground vibration testing results and improve the tracking of structural ...
Andres Jürisson +3 more
doaj +1 more source