Results 61 to 70 of about 1,232,205 (304)

Synthetic cells by the numbers

iScience
Summary: Can we build a living cell from non-living molecular components? This foundational question drives the field of synthetic cell engineering, having already reconstituted key cellular processes within synthetic environments, and now advancing ...
Chana G. Sokolik, Maya Bar-Dolev, Ron Milo, Katarzyna P. Adamala, Michael Levy   +4 more
doaj   +1 more source

Controlling Cell Fate Specification System by Key Genes Determined from Network Structure

iScience, 2018
Summary: Network structures describing regulation between biomolecules have been determined in many biological systems. Dynamics of molecular activities based on such networks are considered to be the origin of many biological functions. Recently, it has
Kenji Kobayashi, Kazuki Maeda, Miki Tokuoka, Atsushi Mochizuki, Yutaka Satou   +4 more
doaj   +1 more source

A Bayesian Framework for Parameter Estimation in Dynamical Models with Applications to Forecasting [PDF]

, 2009
Mathematical models in Biology are powerful tools for the study and exploration of complex dynamics. Nevertheless, bringing theoretical results to an agreement with experimental observations involves acknowledging a great deal of uncertainty intrinsic to
Claudia T. Codeç, Flá
core   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Integration of principles of systems biology and radiation biology: toward development of in silico models to optimize IUdR-mediated radiosensitization of DNA mismatch repair-deficient (damage tolerant) human cancers

Frontiers in Oncology, 2011
Over the last 7 years, we have focused our experimental and computational research efforts on improving our understanding of the biochemical, molecular, and cellular processing of iododeoxyuridine (IUdR) and ionizing radiation (IR) induced DNA base ...
Timothy James Kinsella, Evren eGurkan-Cavusoglu, Weinan eDu, Kenneth eLoparo   +3 more
doaj   +1 more source

Human and computational models of atopic dermatitis:A review and perspectives by an expert panel of the International Eczema Council [PDF]

, 2018
Atopic dermatitis (AD) is a prevalent disease worldwide and is associated with systemic comorbidities representing a significant burden on patients, their families, and society. Therapeutic options for AD remain limited, in part because of a lack of well-
Bieber, Thomas, Bissonette, Robert, Brown, Sara J., Dhar, Sandipan, Eyerich, Kilian, Guttman-Yassky, Emma, Hijnen, Dirk J., Irvine, Alan, Paller, Amy S., Perez White, Bethany E., Reynolds, Nick J., Tanaka, Reiko J., Thyssen, Jacob P., Vestergaard, Christian, Werfel, Thomas, Wollenberg, Andreas   +15 more
core   +6 more sources

Tuneable resolution as a systems biology approach for multi-scale, multi-compartment computational models

Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 2014
The use of multi‐scale mathematical and computational models to study complex biological processes is becoming increasingly productive. Multi‐scale models span a range of spatial and/or temporal scales and can encompass multi‐compartment (e.g., multi ...
D. Kirschner, C. Hunt, Simeone Marino, M. Fallahi‐Sichani, J. Linderman   +4 more
semanticscholar   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Multiparametric imaging of spatio-temporal cAMP signaling, transmembrane potential, and intracellular calcium in the intact heart

iScience
Summary: The spatiotemporal dynamics of intracellular second messengers and signaling molecules, including cyclic adenosine monophosphate (cAMP), have been studied extensively in isolated cardiomyocytes using Förster resonance energy transfer (FRET ...
I-Ju E. Lee, Jessica L. Caldwell, Lilian R. Mott, Jorge L. Gonzalez, Lianguo Wang, Crystal M. Ripplinger   +5 more
doaj   +1 more source