Results 71 to 80 of about 1,232,205 (304)
PLoS Computational Biology, 2020 Practical identifiability of Systems Biology models has received a lot of attention in recent scientific research. It addresses the crucial question for models' predictability: how accurately can the models' parameters be recovered from available ...
Ivan Borisov, Evgeny Metelkin
doaj +1 more source
Anomalous transport in the crowded world of biological cells
, 2013 A ubiquitous observation in cell biology is that diffusion of macromolecules and organelles is anomalous, and a description simply based on the conventional diffusion equation with diffusion constants measured in dilute solution fails.
Franosch, Thomas, Höfling, Felix
core +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
iScienceSummary: Efforts to efficiently target brain tumors are constrained by the dearth of appropriate models to study tumor behavior toward treatment approaches as well as potential side effects to the surrounding normal tissue.
Esther Schickel +7 more
doaj +1 more source
Mathematical and computational modelling of post-transcriptional gene relation by micro-RNA [PDF]
, 2009 Mathematical models and computational simulations have proved valuable in many areas of cell biology, including gene regulatory networks. When properly calibrated against experimental data, kinetic models can be used to describe how the concentrations of
Higham, Desmond J., Khanin, Raya
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Model-driven discovery of synergistic inhibitors against E. coli and S. enterica serovar Typhimurium targeting a novel synthetic lethal pair, aldA and prpC [PDF]
, 2015 Mathematical models of biochemical networks form a cornerstone of bacterial systems biology. Inconsistencies between simulation output and experimental data point to gaps in knowledge about the fundamental biology of the organism.
Amrita Abhay Nagle +16 more
core +4 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Computational Models on Pathological Redox Signalling Driven by Pregnancy: A Review
Antioxidants, 2022 Oxidative stress is associated with a myriad of diseases including pregnancy pathologies with long-term cardiovascular repercussions for both the mother and baby.
Samprikta Manna +9 more
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Early signatures of regime shifts in gene expression dynamics
, 2013 Recently, a large number of studies have been carried out on the early signatures of sudden regime shifts in systems as diverse as ecosystems, financial markets, population biology and complex diseases.
Bose, Indrani +3 more
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Strategies for structuring interdisciplinary education in Systems Biology: an European perspective
npj Systems Biology and Applications, 2016 Systems Biology is an approach to biology and medicine that has the potential to lead to a better understanding of how biological properties emerge from the interaction of genes, proteins, molecules, cells and organisms.
M. Cvijovic +32 more
semanticscholar +1 more source