Results 81 to 90 of about 576,095 (300)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Sentiment Analysis for Software Engineering Domain in Turkish

Sakarya University Journal of Computer and Information Sciences, 2020
The focus of this study is to provide a model to be used for the identification of sentiments of comments about education and profession life of software engineering in social media and microblogging sites.
Mansur Alp Toçoğlu
doaj   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

The past, present, and future of experimental software engineering [PDF]

Journal of the Brazilian Computer Society, 2006
Abstract This paper gives a 40 year overview of the evolution of experimental software engineering, from the past to the future, from a personal perspective. My hypothesis is that my work followed the evolution of the field. I use my own experiences and thoughts as a barometer of how the field has changed and present some opinions about where
openaire   +4 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Sharing Data and Models in Software Engineering Sharing Data and Models [PDF]

, 2015
Data Science for Software Engineering: Sharing Data and Models presents guidance and procedures for reusing data and models between projects to produce results that are useful and relevant.
Turhan, Burak, Peters, Fayola, Minku, Leandro, Menzies, Tim, Kocaguneli, Ekrem   +4 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Envelhecimento de software utilizando ensaios de vida acelerados quantitativos [PDF]

, 2006
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de ProduçãoEste trabalho apresenta uma abordagem sistematizada para acelerar o tempo de vida de sistemas que são acometidos pelos ...
Matias Junior, Rivalino
core  

Automated requirements engineering framework for agile model-driven development

Frontiers in Computer Science
IntroductionAdvances in requirements engineering, driven by various paradigms and methodologies, have significantly influenced software development practices.
Muhammad Aminu Umar, Muhammad Aminu Umar, Kevin Lano, Abdullahi Kutiriko Abubakar   +3 more
doaj   +1 more source